中国科学院生物物理研究所,脑与认知科学重点实验室,研究组长
2011 - 2015 哈尔滨工业大学,自动化专业,学士
2015 - 2020 中科院自动化研究所,模式识别与智能系统,博士
2019 - 2020 The Alan Turing Institute,访问
2020.11 - 中国科学院生物物理研究所,研究员
1.中国科学技术部, 科技创新2030-"脑科学与类脑研究"重大项目, 2022ZD0211900, 多模态多尺度脑图谱技术和平台研究, 2022-08 至 2027-07, 课题负责人
2.国家自然基金委面上项目, 82171543, 基于多模态磁共振和机器学习的精神病理学层级框架及跨诊断应用研究, 2022.1.1-2025.12.31, 在研, 主持
3.中科院战略性先导科技专项B类, XDB32020210,意识状态的宏观神经表征研究, 2021.2-2023.5, 在研, 子课题负责人
抑郁症、精神分裂症、自闭症等精神疾病的病因不明,缺乏个体化的定量生物标记以帮助精准诊疗。针对这一挑战,实验室致力于利用脑成像、人工智能、计算拓扑等多学科交叉方法,以人类和小鼠为研究对象,发展精神疾病定量的脑影像诊疗评估体系:
1. 脑影像大数据建模研究
通过多模态神经影像的数据挖掘和深度学习表征,我们关注建立个体水平稳定的影像学标记,以通过无损方式区分多种精神疾病患者及其内部亚型。
2. 功能磁共振动态脑网络研究
一千个人有一千个哈姆雷特,我们关注不同人在相同自然态刺激(如看电影)下脑网络动态功能表征,从中解码认知和心理健康的个体差异。
3. 跨物种跨尺度脑网络研究
融合人类和小动物神经影像表型以及多组学数据资源,跨尺度解析精神疾病的病理机制。
随时欢迎具有计算机、心理学、生物学等不同专业背景的学生以硕博研究生、实习生、科研助理等不同身份加入或访问!
1.Ang Li*, Haiyang Liu, Xu Lei, Yini He, Qian Wu, Yan Yan, Xin Zhou, Xiaohan Tian, Yingjie Peng, Shangzheng Huang, Kaixin Li, Meng Wang, Yuqing Sun, Hao Yan, Cheng Zhang, Sheng He, Ruquan Han, Xiaoqun Wang & Bing Liu. Hierarchical fluctuation shapes a dynamic flow linked to states of consciousness.Nature Communications, 2023, 14: 3238. (Co-corresponding author)
2. Meng Wang, Hao Yan, Xiaohan Tian, Weihua Yue, Yong Liu, Lingzhong Fan, Ke Hu, Yuqing Sun, Yuxin Zhao, Jing Lou, Ming Song, Peng Li, Jun Chen, Yunchun Chen, Huaning Wang, Wenming Liu, Zhigang Li, Yongfeng Yang, Hua Guo, Luxian Lv, Jun Yan, Huiling Wang, Hongxing Zhang, Huawang Wu, Yuping Ning, Lin Lu, Dai Zhang,Ang Li*, Tianzi Jiang* & Bing Liu* Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia.Nature Mental Health, 2023, 1: 633-654. (Co-corresponding author)
3.Ang Li, Andrew Zalesky, Weihua Yue, Oliver Howes, Hao Yan, Yong Liu, Lingzhong Fan, Kirstie J Whitaker, Kaibin Xu, Guangxiang Rao, Jin Li, Shu Liu, Meng Wang, Yuqing Sun, Ming Song, Peng Li, Jun Chen, Yunchun Chen, Huaning Wang, Wenming Liu, Zhigang Li, Yongfeng Yang, Hua Guo, Ping Wan, Luxian Lv, Lin Lu, Jun Yan, Yuqing Song, Huiling Wang, Hongxing Zhang, Huawang Wu, Yuping Ning, Yuhui Du, Yuqi Cheng, Jian Xu, Xiufeng Xu, Dai Zhang, Xiaoqun Wang, Tianzi Jiang & Bing Liu. A neuroimaging biomarker for striatal dysfunction in schizophrenia.Nature Medicine, 2020, 26: 558-565.
4. Shu Liu#,Ang Li#, Meifang Zhu, Jin Li, Bing Liu. Genetic influences on cortical myelination in the human brain[J].Genes, Brain and Behavior, 2019, 18(4): e12537.
5. Yan Yan, Xuankun Wu, Chengdong Li, Yini He, Zhicheng Zhang, Huihui Li,Ang Li*, Lei Wang*. Topological EEG Nonlinear Dynamics Analysis for Emotion Recognition.IEEE Transactions on Cognitive and Developmental Systems, 2022
6. Haiyang Liu, Ke Hu, Yingjie Peng, Xiaohan Tian, Meng Wang, Bo Ma, Youxuan Wu, Wanchen Sun, Bing Liu,Ang Li*, Ruquan Han*. Dynamic reconfiguration of human brain networks across altered states of consciousness. Behavioural Brain Research, 2022, 419: 113685.
7. Guangxiang Rao,Ang Li, Yong Liu, Bing Liu. A High-Powered Brain Age Prediction Model Based on Convolutional Neural Network.The IEEE International Symposium on Biomedical Imaging, 2020
8. Shu Liu,Ang Li, Yong Liu, Jin Li, Meng Wang, Yuqing Sun, Wen Qin, Chunshui Yu , Tianzi Jiang, Bing Liu. MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.Psychological Medicine, 2019: 1-9.
9. Shu Liu,Ang Li, Yong Liu, Hao Yan, Meng Wang, Yuqing Sun, Lingzhong Fan, Ming Song, Kaibin Xu, Jun Chen, Yunchun Chen, Huaning Wang, Hua Guo (a10), Ping Wan, Luxian Lv, Yongfeng Yang, Peng Li, Lin Lu , Jun Yan, Huiling Wang, Hongxing Zhang, Huawang Wu, Yuping Ning, Dai Zhang, Tianzi Jiang and Bing Liu. Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus.The British Journal of Psychiatry, 2019: 1-8.
10. Jiachen Li, Dan Jin,Ang Li, Bing Liu, Chengyuan Song, Pan Wang, Dawei Wang, Kaibin Xu, Hongwei Yang, Hongxiang Yao, Bo Zhou, Alexandre Bejanin, Gael Chetelat, Tong Han, Jie Lu, Qing Wang, Chunshui Yu m, Xinqing Zhang, Yuying Zhou, Xi Zhang, Tianzi Jiang, Yong Liu, Ying Han. ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI.Science Bulletin, 2019
11. Jin Li, Xiaolong Zhang,Ang Li, Shu Liu, Wen Qin, Chunshui Yu, Yong Liu, Bing Liu, Tianzi Jiang. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations[J].Neurobiology of aging, 2018, 64: 116-122.
12. Tianqi Wang, Xiaolong Zhang,Ang Li, Meifang Zhu, Shu Liu, Wen Qin, Jin Li, Chunshui Yu, Tianzi Jiang, Bing Liu. Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations[J].NeuroImage: Clinical, 2017, 14: 441-449.
(资料来源:李昂研究员,2024-09-14)