娄继忠
/ 博士 研究员 博士生导师
中国科学院生物物理研究所，表观遗传调控与干预重点实验室，研究组长
简历
1990 – 1994 吉林大学，学士
1994 – 1997 北京大学，硕士
1997 – 2000 中国科学院理论物理研究所，博士
2000 – 2001 内华达大学拉斯韦加斯分校，博士后
2001 – 2005 佐治亚理工学院，博士后
2005 – 2009 佐治亚理工学院，研究科学家
2009 – 至今 中国科学院生物物理研究所研究员，博士生导师
获奖及荣誉
社会任职
承担项目情况
本课题组以单分子生物物理学和分子动力学模拟为主要研究手段，结合免疫学、生物化学及其它生物物理学方法，聚焦于研究T细胞免疫活化及其调控机制，一方面试图阐明生理条件下关键免疫受体与配体的识别模式，深入理解免疫信号产生、跨膜转导、细胞响应等重要生物学过程的分子机制；另一方面试图从中发现新位点或新靶标，并在解析基因编辑工具功能机制的基础上，发展T细胞特异的基因编辑方法以对其进行功能化改造，为新型免疫治疗策略的研发与优化提供理论基础。
1. Yiran Chen#, Li Li#, Jie Lan#, Yang Cui, Xiaosong Rao, Jing Zhao, Tao Xing, Gaoda Ju, Guangtao Song*,Jizhong Lou*, and Jun Liang*. CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma.Mol Cancer. 2022 Jan 4;21(1):11. doi: 10.1186/s12943-021-01466-9.
2. Juan Fan#, Jiawei Shi#, Yong Zhang#, Junwei Liu, Chenyi An, Huaying Zhu, Peng Wu, Wei Hu, Danmei Yao, Xin Shou, Yibing Xu, Weijia Fang, Zhou Tong, Xue Wen,Jizhong Lou*, Weiwei Yin*, and Wei Chen*. NKG2D sensitively discriminates diverse ligands through selectively mechano-regulated ligand conformational changes.EMBO J. 2022 Dec 17;41(2):e107739. doi: 10.15252/embj.2021107739.
3. Wei Hu#, Yong Zhang#, Panyu Fei#, Tongtong Zhang#, Danmei Yao#, Yufei Gao, Jia Liu, Hui Chen, Qiao Lu, Tenny Mudianto, Xinrui Zhang, Chuxuan Xiao, Yang Ye, Qiming Sun, Jing Zhang, Qi Xie, Pei-Hui Wang, Jun Wang*, Zhenhai Li*,Jizhong Lou*, and Wei Chen*. Mechanical activation of spike fosters SARS-CoV-2 viral infection.Cell Res. 2021 Oct;31(10):1047-1060.
4. Hui Chen, Yang Cui, Xuling Han, Wei Hu, Min Sun, Yong Zhang, Pei-Hui Wang, Guangtao Song, Wei Chen*, andJizhong Lou*. Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA.Cell Res. 2020 Dec; 30(12):1143-1145.. doi: 10.1038/s41422-020-00408-2.
5. Yang Cui, Yangchao Tang, Meng Liang, Qinghua Ji, Yan Zeng, Hui Chen, Jie Lan, Peng Jin, Lei Wang, Guangtao Song*, andJizhong Lou*. Direct Observation of the Formation of a CRISPR-Cas12a R-loop Complex at the Single-Molecule Level.Chem Commun (Camb). 2020,56 (14), 2123-2126.
6. Wei Hu#, Yong Zhang#, Xiaolin Sun#, Tongtong Zhang, Liling Xu, Hengyi Xie, Zhanguo Li, Wanli Liu*,Jizhong Lou*, and Wei Chen*. FcγRIIB-I232T Polymorphic Change Allosterically Suppresses Ligand Binding.eLife. 2019;8:e46689.
7. Peng Wu#, Tongtong Zhang#, Baoyu Liu#, Panyu Fei#, Lei Cui#, Rui Qin, Huaying Zhu, Danmei Yao, Ryan J. Martinez, Wei Hu, Chenyi An, Yong Zhang, Junwei Liu, Jiawei Shi, Juan Fan, Weiwei Yin, Jie Sun, Chun Zhou, Xun Zeng, Chenqi Xu, Jianan Wang, Brian D. Evavold, Cheng Zhu, Wei Chen* andJizhong Lou*. Mechano-regulation of peptide-MHC class I conformations determines TCR antigen recognition.Mol Cell. 2019 Mar 7;73(5):1015-1027.e7.
8. Song G, Chen H, Sheng G, Wang Y*,Lou J.*. Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome.Biochemistry. 2018 Apr 17;57(15):2179-2183.
9. Zeng Y#, Cui Y#, Zhang Y, Zhang Y, Liang M, Chen H, Lan J, Song G*, andLou J*. The Initiation, Propagation and Dynamics of CRISPR-SpyCas9 R-loop Complex.Nucleic Acids Research. 2018 Jan 9;46(1):350-361.
（资料来源：娄继忠研究员，2022-03-31）
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研究生
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毕业学生