发表论文

1. Zhu Y, Wang L, Li J, Zhao Y, Yu X, Liu P, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z*,Wang L*, Luo T* (2024) Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice.Cell Chem Bioldoi.org/10.1016/j.chembiol.2023.10.003.

2. Liu P, Hu J,Wang L*(2024) SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic.Protein & Cell15: 79-82.

3. Cheng F, Ji Q, Wang L, Wang CC, Liu GH*,Wang L*(2023) Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H₂O₂release.EMBO Rep24: e56439.

(Selected as a cover story on EMBO Reports)

4. Liu P, Wang X*, Sun Y, Zhao H, Cheng F, Wang J, Yang F, Hu J, Zhang H, Wang CC,Wang L*(2022) SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases.Redox Biol54:102388.

5. Wang L*, Wang X, Lv X, Jin Q, Shang H, Wang CC,Wang L*(2022) The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential.Redox Biol50: 102244

6. Qiao X, Zhang Y, Ye A, Zhang Y, Xie T, Lv Z, Shi C, Wu D, Chu B, Wu X, Zhang W, Wang P, Liu GH, Wang CC,Wang L*, Chen C* (2022) Reductive stress in the endoplasmic reticulum caused by Ero1α S-nitrosation accelerates senescence.Free Radic Biol Med180: 165-178.

7. Fan F, Zhang Q, Zhang Y, Huang G, Liang X, Wang CC,Wang L*, Lu D* (2022) Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding.Plant Physiol188: 241-254.

8. Chen X, Zhang J, Liu P, Wei Y, Wang XE, Xiao J, Wang CC,Wang L*(2021) Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.Proc Natl Acad Sci U S A118: e2100133118.

9. Yan Y, Wu X, Wang P, Zhang S, Sun L, Zhao Y, Zeng GY, Liu B, Xu G, Liu H,Wang L*, Wang X* and Jiang C* (2020) Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.Redox Biol37: 101742.

10. Yu J, Li T, Liu Y, Wang X, Zhang J, Wang Xe, Shi G, Lou J, Wang L, Wang CC,Wang L*(2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.EMBO J39: e103841

(Highlighted by EMBO J 'News & Views'; Recommended by F1000Prime)

11. Fan F, Zhang Y, Huang G, Zhang Q, Wang CC,Wang L*, Lu D* (2019) AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER.Plant Physiol180:2022-2033.

12. Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang Xe, Wang X, Liu Y, Lu B, Wei T, Wang CC,Wang L*(2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer.EBioMedicine41:408-419.

13. Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang CC, Feng J*,Wang L*(2019) Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis.Redox Biol20: 46-59.

14. Zhang J, Zhu Q, Wang Xe, Yu J, Chen X, Wang J, Wang X, Xiao J, Wang CC,Wang L*(2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.EMBO J37: e98699.

15. Fang J, Yang J, Wu X, Zhang G, Li T, Wang Xe, Zhang H, Wang CC, Liu GH*,Wang L*(2018) Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.Aging Cell17: e12765.

16. Li H, Yang K, Wang W, Niu Y, Li J, Dong Y, Liu Y, Wang CC,Wang L*, Liang H* (2018) Crystal and solution structures of human protein disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity.J Biol Chem293, 1192-1202.

17. Fan F, Zhang Y, Wang S, Han Y,Wang L*, Lu D* (2018) Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11.Biochem Biophys Res Commun495:1041-1047.

18. Niu Y, Zhang L, Yu J, Wang CC* andWang L*(2016) Novel roles of the non-catalytic elements of yeast protein-disulfide isomerase in its interplay with endoplasmic reticulum oxidoreductin 1.J Biol Chem291:8283-8294.

19. Zhang L, Niu Y, Zhu L, Fang J, Wang Xe,Wang L*and Wang CC* (2014) Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α).J Biol Chem289:31188-31199.

20.Wang L*, Zhang L, Niu Y, Sitia R and Wang CC* (2014) Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding.Antioxid Redox Signal20: 545-556.

21.Wang L, Zhu L and Wang CC (2011) The Endoplasmic Reticulum Sulphydryl Oxidase Ero1β Drives Efficient Oxidative Protein Folding with Loose Regulation.Biochem J434:113-121.

22.Wang L, Li SJ, Sidhu A, Zhu L, Liang Y, Freedman RB, and Wang CC* (2009) Reconstitution of human Ero1-Lα/protein disulfide isomerase oxidative folding pathway in vitro: position-dependent differences in role between the a and a' domains of protein disulfide isomerase.J Biol Chem284: 199-206.

综述 & 评论 (*责任作者)

1. Cheng F,Wang L*(2024) Slowing down the central dogma rate for alleviating aging.Innovation Life2: 100049.

2. 胡昕炜, 王志珍,王磊*(2023)"后AlphaFold时代"的蛋白质折叠问题. 《科学通报》 68: 2943-2950.

3.Wang L*, Wang CC (2023) Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum.Trends Biochem Sci48: 40-52.

4.Wang L*, Yu J, Wang CC (2021) Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities and pathophysiological functions.BioEssays43: e2000147.

5.Wang L, Wang X, Wang CC* (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone.Free Radical Bio Med83:305-313.

6. 王曦,王磊, 陈畅, 王志珍 (2014) 未折叠蛋白响应: 2014年拉斯克基础医学研究奖解读. 《科学通报》59: 3533-3534.

全部发表论文

https://scholar.google.com/citations?hl=en&user=NUni5KMAAAAJ

ORCID: 0000-0002-5071-5800

（资料来源：王磊研究员，2024-02-02）