阎锡蕴课题组

　　1977 – 1982 河南医科大学，医学学士

　　1983 – 1989 中国科学院生物物理研究所，实研，助研

　　1989 – 1993 德国海德堡大学理论医学院，博士

　　1994 – 1996 美国Memorial Sloan-Kettering癌症研究中心，博士后

　　1994 – 至今 中国科学院微生物研究所研究员、中国科学院生物物理研究所研究员, 博导

　　2012年 国家自然科学奖二等奖

　　2015年 Atlas国际奖

　　2008年 北京市科学技术奖一等奖

　　2010年 北京市科学技术奖一等奖

　　2014年 北京市科学技术奖一等奖

　　2010年 中国科学院先进工作者

　　2010年 全国优秀科技工作者

　　2011年 中国科学院“优秀研究生指导教师”奖

　　2012年 中国科学院第四届十大杰出妇女

　　2013年 首届中国科学院王宽诚优秀女科学家奖（两位获奖者之一）

　　2015年 全国三八红旗手

　　2017年 全国创新争先奖

　　2018年 第十一届谈家桢生命科学奖成就奖

　　2019年 2018年度全国三八红旗手标兵

　　1. 肿瘤免疫学研究：发现新靶点、发展肿瘤精准治疗新策略；

　　2. 纳米酶催化机制及应用研究：探究纳米酶的催化机制，实现其可控制备，拓展纳米酶在疾病诊断、传染病监测、污水治理等方面应用研究。

主要科学贡献：

　　1. 发现纳米酶（Nature Nanotechnology，2007，单篇他引超过1900次），提出纳米酶新概念，并将其标准化。研究团队长期致力于纳米酶的机制及应用研究，并发展多项基于纳米酶的“新技术”。设计并研发用于疾病诊断的纳米酶试纸条，获得医疗器械证书，成为全球首个纳米酶新产品。通过创制多酶活性纳米酶，利用肿瘤微环境启动过氧化物酶活性催化产生活性氧杀死肿瘤细胞，探索纳米酶催化治疗新策略。纳米酶应用的相关研究成果先后获得国家自然科学奖二等奖（2012年）和Atlas国际奖（2015年）。目前，全球有29个国家的290个实验室从事300余种纳米酶研究，其应用研究涉及生物、医学、农业、环境治理等，形成了一个新的研究领域。

　　2. 发现肿瘤血管新靶点CD146（Blood，2003）。 此项发现被Faculty1000评为新发现。随后十余年，整个团队系统地研究了CD146促进肿瘤发生发展和转移的机制，首次鉴定了CD146的配体，并制备出了靶向CD146的人源化抗体药物，在肝癌、胰腺癌和结肠癌的治疗研究中取得突破进展。其系统性工作成果相继发表于Nature Communications、Blood、PNAS等高水平杂志。靶向CD146的肿瘤治疗新策略，获北京市科学技术奖一等奖并实现了成果转化；功能性抗体AA98目前正处于临床前研究阶段。

Nanozyme & Ferritin:

1.Xiyun Yan,Nanozymology, Springer, 2020, ISBN 978-981-15-1489-0，ISBN 978-981-15-1490-6 (eBook)

2. Lizeng Gao, Jie Zhuang, Leng Nie, Jinbin Zhang, Yu Zhang, Ning Gu, Taihong Wang, Jing Feng, Dongling Yang, Sarah Perrett*,Xiyun Yan*. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles and application in an immunoassay.Nature Nanotechnology. 2007, 2 (9) 577.

3. Kelong Fan, Changqian Cao, Yongxin Pan, Di Lu, Dongling Yang, Jing Feng, Lina Song, Minmin Liang*,Xiyun Yan*. Magnetoferritin nanoparticles for targeting and visualizing tumor tissues.Nature Nanotechnology. 2012, 7(7), 4594.

4. Minmin Liang, Kelong Fan, Meng Zhou, Demin Duan, Jiyan Zheng, Dongling Yang, Jing Feng andXiyun Yan*. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection.Proceedings of the National Academy of Sciences of the United States of America. 2014,111(41) ,14900.

5. Demin Duan, Kelong Fan, Dexi Zhang, ShuguangTan, Mifang Liang, Yang Liu, Jianlin Zhang, PanheZhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger, George Fu Gao,Xiyun Yan*. Nanozyme-strip for rapid local diagnosis of Ebola.Biosensors and Bioelectronic. 2015, 74(5),134.

6. Yanzhao Zhao, Minmin Liang, Xiao Li, Kelong Fan, Jie Xiao, Yanli Li, Hongcheng Shi, Fei Wang, Hak Soo Choi*, Dengfeng Cheng*,Xiyun Yan*. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging.ACS Nano. 2016; 10 (4), 4184-4191

7. Bing Jiang, Demin Duan, Lizeng Gao, Mengjie Zhou, Kelong Fan, Yan Tang, Juqun Xi, Yuhai Bi, Zhou Tong, George Fu Gao, Ni Xie, Aifa Tang, Guohui Nie, Minmin Liang*,Xiyun Yan*. Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes.Nature Protocols. 2018

8. Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang,Xiyun Yan*, Lizeng Gao*. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy.Nature Communications. 2018, 9(1), 1440.

9. Minmin Liang, Hui Tan, Jun Zhou, Tao Wang, Demin Duan, Kelong Fan, Jiuyang He, Dengfeng Cheng*, Hongcheng Shi*, Hak Soo Choi*, andXiyun Yan*. Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis.  ACS Nano. 2018, 12(9), 9300.

10. Bolong Xu, Hui Wang, Weiwei Wang, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang, Hailong Yang, Xiangqin Meng, Qiuwen Wu, Lirong Zheng, Shenming Chen, Xinghua Shi, Kelong Fan*,Xiyun Yan*, Huiyu Liu*. Single-Atom Nanozyme for Wound Antibacterial Applications.Angewandte Chemie International Edition. 2019, 10.1002/ange.201813994

11. Kelong Fan*, Xiaohua Jia, Meng Zhou, Kun Wang, Joao Conde, Jiuyang He, Jie Tian*,Xiyun Yan*. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma.ACS Nano. 2018, 12, 4105.

12. Shuai Zhao, Hongxia Duan, Yili Yang,Xiyun Yan*, Kelong. Fenozyme Protects the Integrity of Blood Brain Barrier against Experimental Cerebral Malaria.Nano Letters. 2019, 19, 8887

13．Bing Jiang, Xuehui Chen, Guoming Sun, Xiangru Chen, Yufang Yin, Yiliang Jin, Qian Mid, Long M, Yili Yang,Xiyun Yan*, Kelong Fan*. A natural drug entry channel in the ferritin nanocage.Nano Today. 2020, 35, 100948.

14. Qian Liang, Juqun Xi, Xuejiao J. Gao, Ruofei Zhang, Yili Yang, Xingfa Gao,Xiyun Yan*, Lizeng Gao*, Kelong Fan*. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy.Nano Today. 2020, 35, 100935.

15. Zhuoran Wang, Ruofei Zhang,Xiyun Yan*, Kelong Fan*. Structure and activity of nanozymes: Inspirations for de novo design of nanozymes.Materials Today. 2020, 41, 81.

16. Xiaojing Cheng, Kelong Fan, Lin Wang, Xiangji Ying, Andrew J. Sanders, Ting Guo, Xiao fang Xing, Meng Zhou, Hong Du, Ying Hu, Huirong Ding, Ziyu Li, Xianzi Wen, Wenguo Jiang*,Xiyun Yan*, Jiafu Ji*. TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer.Cell Death & Disease. 2020, 11(2), 92.

CD146:

1. 段红霞, 熊朝亮, 景林, 徐庆吉, 刘晶玉, 马欣然, 王大吉, 向建全, 何志恒, 冯静*,阎锡蕴*. CD146三十年研究的回顾与展望.中国科学：生命科学. 2020, 50(12),1339.

2.Xiyun Yan*, Yun Lin, Dongling Yang, Yi Shen, Mei Yuan, Zhiqiang Zhang, Peiyu Li, Hongtian Xia, Li Li, Dandan Luo, Qin Liu, Karlheinz Mann, Bernhard L. Bader. A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth.Blood. 2003, 102 (1), 184.

3. Yanyong Kang, Fengcai Wang, Jing Feng, Dongling Yang , Xu Yang,Xiyun Yan*. Knockdown of CD146 reduces the migration and proliferation of human endothelial cells.Cell Research.2006, 16, 313.

4. Qin Liu,Bairu Zhang, Xingang Zhao, Ying Zhang, Yixun Liu,Xiyun Yan*. Blockade of Adhesion Molecule CD146 Causes Pregnancy Failure in Mice.Journal of Cellular Physiology. 2015, 3, 621.

5. Tianxia Jiang, Jie Zhuang, Hongxia Duan, Yongting Luo, Qiqun Zeng, Kelong Fan, Huiwen Yan, Di Lu, Zhongde Ye, Junfeng Hao, Jing Feng, Dongling Yang,Xiyun Yan*. CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis.Blood. 2012, 120 (11), 2330.

6. Zhongde Ye, Chunxia Zhang, Tao Tu, Min Sun, Dan Liu, Di Lu, Jing Feng, Dongling Yang, Feng Liu*,Xiyun Yan*. Wnt5a uses CD146 as a receptor to regulatecell motility and convergent extension.Nature Communications. 2013;4,2803.

7. Tao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y. Wu*,Xiyun Yan*. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development.Cell Research. 2015, 25(3), 275.

8. Yongting Luo, Hongxia Duan, Yining Qian, Liqun Feng, Zhenzhen Wu, Jing Feng, Dongling Yang, Zhihai Qin,Xiyun Yan*. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis.Cell Research, 2017.

9. Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang*, Anming Meng*,Xiyun Yan*. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.Nature Communications. 2017, 7(8), 15279.

10. Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang*,Xiyun Yan*. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.Proceedings of the National Academy of Sciences of the United States of America. 2017, 114(36),  E7622.

11. Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng* &Xiyun Yan*.  Publisher Correction: CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.Nature Communications. 2019 Aug 7;10(1):3551.

12. Daji Wang, Hongxia Duan, Jing Feng, Jianquan Xiang, Liqun Feng, Dan Liu, Xuehui Chen, Lin Jing, Zheng Liu, Dexi Zhang, Hongjun Hao,Xiyun Yan. Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction.Theranostics. 2020, 10(1), 231.

13. Hongxia Duan*, Shuai Zhao, Jianquan Xiang, Chenhui Ju, Xuehui Chen, Irene Gramaglia,Xiyun Yan*. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.Cellular & Molecular Immunology. 2020, doi.org/10.1038/s41423-020-00582-8

14. Zhenzhen Wu, Jingyu Liu, Gang Chen, Junfeng Du, Huiyun Cai, Xuehui Chen, Gaoqi Ye,Yongting Luo, Yiyi Luo, Liwen Zhang, Hongxia Duan, Zheng Liu, Sai Yang, Hongwei Sun,Yan Cui, Lei Sun, Hongjie Zhang, Guizhi Shi, Taotao Wei, Pingsheng Liu,Xiyun Yan*, Jing Feng*, Pengcheng Bu*. CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure.Advanced Science. 2021, doi.org/10.1002/advs.202004032

（资料来源：阎锡蕴院士，2021-02-26）