1992 M.D., Free University of Berlin, Germany;

1992 - 1994 Post-Doc fellow, Fox Chase Cancer Center, Philadelphia, U.S.A.;

1994 - 2000 Senior research fellow, MDC for Molecular Medicine, Berlin;

2000 - 2005 Research project leader, Institute of Immunology, FU Berlin, Germany;

2005 - Principle investigator, Institute of Biophysics Chinese Academy of Sciences, Beijing

The pro-inflammatory cytokine-mediated stroma cell interactions exert both beneficial and adverse effects on tumor progression. The finding of key regulatory molecules and understanding of corresponding mechanisms help to develop novel strategies for tackling cancer by modifying stroma cell interactions.

- Non-hematopoietic cells are important immune effector cells. Our results showed that responsiveness of stroma fibroblasts to IFNg blocks tumor growth via angiostasis, which reveals a novel link between immune cells and non-bone marrow-derived stroma cells, and de?nes stroma ?broblasts as the main targets of IFNg in tumor immunity.

- Stroma fibroblast-mediated foreign body reaction acts as an important way to prevent tumorigenesis. The depletion of fibroblasts demonstrated that fibroblasts play an indispensable role in preventing epithelial malignancy by the collagen deposition around carcinogen and provide a novel mechanism for host surveillance against cancer.

- Tumor stroma cell interactions influence tumor development. Our results demonstrate that tumor stroma is not only bystanders during tumor development. The interaction between different pro-inflammatory cytokines and between cytokines and stromal cells could promote or inhibit tumor development. It is of great important to understand these interactions and make use of it to attack tumor.

1. Xue, R*., Sheng, Y., Duan, X., Yang, Y., Ma, S., Xu, J., Wei, N., Shang, X., Li, F., Wan, J. andQin, Z*. (2020), Tie2‐expressing monocytes as a novel angiogenesis‐related cellular biomarker for non‐small cell lung cancer.Int. J. Cancer.

2. Li Y, Wang J, Song K, Liu S, Zhang H, Wang F, Ni C, Zhai W, Liang J,Qin Z*, Zhang J*. S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness.Oncoimmunology. 2020 Feb 14;9(1):1725355.

3. Jiang H, Zhang L, Liu X, Sun W, Kato K, Chen C, Li X, Li T, Sun Z, Han W, Zhang F, Xiao Q, Yang Z, Hu J,Qin Z, Adams RH, Gao X, He Y*. Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation.Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):958-972.

4. Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms HC, Puchkov D, Devraj K, Kaya M,Qin Z, Liebner S, Wolburg H, Andjelkovic AV, Rex A, Blasig IE, Haseloff RF*. Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins.J Cereb Blood Flow Metab. 2020 Feb 13:271678X20904687.

5. Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, Schmidt F, Friedrich M, Keye J, Wan J, Qin Y, Kühl AA,Qin Z*, Siegmund B, Glauben R*. Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.EMBO Mol Med. 2019 Nov 7;11(11):e10698.

6. Deng L, Feng Z, Deng H*, Jiang Y, Song K, Shi Y, Liu S, Zhang J, Bai S,Qin Z*, Dong A*. Rational Design of Nanoparticles to Overcome Poor Tumor Penetration and Hypoxia-Induced Chemotherapy Resistance: Combination of Optimizing Size and Self-Inducing High Level of Reactive Oxygen Species.ACS Appl Mater Interfaces. 2019 Sep 4;11(35):31743-31754.

7. Zhang L, Qi Y, Min H, Ni C, Wang F, Wang B, Qin H, Zhang Y, Liu G, Qin Y, Duan X, Li F, Han X, Tao N, Zhang L,Qin Z*, Zhao Y*, Nie G*. Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy.ACS Nano. 2019 May 28;13(5):5091-5102.

8. Ji T, Lang J, Ning B, Qi F, Wang H, Zhang Y, Zhao R, Yang X, Zhang L, Li W, Shi X,Qin Z*, Zhao Y*, Nie G*. Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes.Adv Mater. 2019 Feb;31(6):e1804395.

9. Ni C, Ma P, Wang R, Lou X, Liu X, Qin Y, Xue R, Blasig I, Erben U,Qin Z*. Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes.J Pathol. 2019 Mar;247(3):320-332.

10. Zhang J, Hou S, Gu J, Tian T, Yuan Q, Jia J,Qin Z, Chen Z. S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis.Oncoimmunology. 2018 Jun 11;7(8):e1461301.

11. Li Y, Bao J, Bian Y, Erben U, Wang P, Song K, Liu S, Li Z, Gao Z,Qin Z*. S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts.Front Immunol. 2018 Aug 6;9:1776.

12. Sheng Y, Li F,Qin Z*. TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors.Front Immunol. 2018 May 28;9:1170.

13. Zhang J, Song K, Wang J, Li Y, Liu S, Dai C, Chen L, Wang S,Qin Z*. S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity.Oncoimmunology. 2018 Jan 23;7(4):e1296996.

14. Li Q, Dai C, Xue R, Wang P, Chen L, Han Y, Erben U,Qin Z*. S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4-ERK1/2 Signaling.Front Immunol. 2018 Mar 5;9:388.

15. Deng H, Song K, Zhang J, Deng L, Dong A*,Qin Z*. Modulating the rigidity of nanoparticles for tumor penetration.Chem Commun (Camb). 2018 Mar 25;54(24):3014-3017.

16. Hou S, Tian T, Qi D, Sun K, Yuan Q, Wang Z,Qin Z, Wu Z, Chen Z*, Zhang J*. S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition.Cell Death Dis. 2018 Feb 15;9(3):277.

17. Liu J, Kang SG, Wang P, Wang Y, Lv X, Liu Y, Wang F, Gu Z, Yang Z, Weber JK, Tao N,Qin Z, Miao Q, Chen C, Zhou R, Zhao Y. Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor.Biomaterials. 2018 Jan;152:24-36. doi: 10.1016/j.biomaterials.2017.10.027. Epub 2017 Oct 16. PMID: 29080421.

18. Ji T, Lang J, Wang J, Cai R, Zhang Y, Qi F, Zhang L, Zhao X, Wu W, Hao J,Qin Z*, Zhao Y*, Nie G*. 2017. Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy.ACS Nano, 11(9):8668-8678.

19. Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U,Qin Z*. 2017. Accelerated tumour metastasis due to interferon-gamma receptor-mediated dissociation of perivascular cells from blood vessels.J Pathol, 242(3):334-346.

20. Deng H, Song K, Zhao X, Li Y, Wang F, Zhang J, Dong A,Qin Z*. 2017. Tumor Microenvironment Activated Membrane Fusogenic Liposome with Speedy Antibody and Doxorubicin Delivery for Synergistic Treatment of Metastatic Tumors.ACS Appl Mater Interfaces, 9(11):9315-9326.

21. Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B,Qin Z*. 2017. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.Cell Mol Immunol, 14(7):597-606.

22. Shao W, Zhang C, Liu E, Zhang L, Ma J, Zhu Z, Gong X,Qin Z*,Qiu X*. 2016. Identification of Liver Epithelial Cell-derived Ig Expression in mu chain-deficient mice.Sci Rep6: 23669

23. Atretkhany KS, Nosenko MA, Gogoleva VS, Zvartsev RV,Qin Z,Nedospasov SA, Drutskaya MS*. 2016. TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation.Front Immunol7: 147

24. Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z*. 2016. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.Cell Mol Immunol.

25. Chen L, Li J, Wang F, Dai C, Wu F, Liu X, Li T, Glauben R, Zhang Y, Nie G, He Y*,Qin Z*.2016. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy.Cancer Res

26. Ji T, Zhao Y, Ding Y, Wang J, Zhao R, Lang J, Qin H, Liu X, Shi J, Tao N,Qin Z, Nie G*. 2016. Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation.Angew Chem Int Ed Engl. 55(3): 1050–1055.

27. Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, Zhang H, Ding P, Sun X,Qin Z*,Zhao Y*. 2015. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells.Sci Rep5: 14871

28. Yang S, Wang Y, Mei K, Zhang S, Sun X, Ren F, Liu S, Yang Z, Wang X,Qin Z, Chang Z*. 2015. Tumor necrosis factor receptor 2 (TNFR2).interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-kappaB activation.J Biol Chem290: 861-71

29. Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y,Qin Z, Fu YX*, Wang S*. 2015. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype.J Immunol194: 4997-5006

30. Zhang J*, Ni C, Yang Z, Piontek A, Chen H, Wang S, Fan Y,Qin Z, Piontek J. 2015. Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier.Exp Dermatol24: 605-10

31. Ji T, Ding Y, Zhao Y, Wang J, Qin H, Liu X, Lang J, Zhao R, Zhang Y, Shi J, Tao N,Qin Z*,Nie G*. 2015. Peptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug delivery.Adv Mater27: 1865-73

32. Chen L, Li J, Zhang J, Dai C, Liu X, Wang J, Gao Z, Guo H, Wang R, Lu S, Wang F, Zhang H, Chen H, Fan X, Wang S,Qin Z*.2015. S100A4 promotes liver fibrosis via activation of hepatic stellate cells.J Hepatol62: 156-64

33. Xing S, Luo Y, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D,Qin Z, Yan X*. 2014. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis.Am J Pathol184: 1604-16

34. Ni C, Wang C, Zhang J, Qu L, Liu X, Lu Y, Yang W, Deng J, Lorenz D, Gao P, Meng Q, Yan X, Blasig IE,Qin Z*.2014. Interferon-gamma Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis.Am J Pathol184: 3308-20

35. Hu X, Li B, Li X, Zhao X, Wan L, Lin G, Yu M, Wang J, Jiang X, Feng W,Qin Z, Yin B*, Li Z*. 2014. Transmembrane TNF-alpha promotes suppressive activities of myeloid-derived suppressor cells via TNFR2.J Immunol 192: 1320-31

36. Gao P, Tao N, Ma Q, Fan WX, Ni C, Wang H,Qin ZH*.2014. DH332, a synthetic beta-carboline alkaloid, inhibits B cell lymphoma growth by activation of the caspase family.Asian Pac J Cancer Prev15: 3901-6

37. Deng J, Liu X, Rong L, Ni C, Li X, Yang W, Lu Y, Yan X, Qin C, Zhang L,Qin Z*.2014. IFNgamma-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4.J Pathol233: 170-82

38. Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T,Qin Z*.2013. Fibroblast-Specific Protein 1/S100A4-Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens.Cancer Res73: 2770-81

39. Zhang G, Liu X, Wang C, Qu L, Deng J, Wang H,Qin Z*.2013. Resolution of PMA-induced skin inflammation involves interaction of IFN-gamma and ALOX15.Mediators Inflamm2013: 930124

40. Wang J, Wang X, Gao C, Song X, Niu Z, Gao Z,Qin Z, Chang J*, Wang H*. 2013. The pyrimidine analog FNC inhibits cell proliferation and viral protein synthesis in HTLV1infected cells.Mol Med Rep7: 1656-60

41. Wang J, Niu Z, Shi Y, Gao C, Wang X, Han J, Li J, Gao Z, Zhu X, Song X,Qin Z*,Wang H*. 2013. Bcl-3, induced by Tax and HTLV-1, inhibits NF-kappaB activation and promotes autophagy.Cell Signal25: 2797-804

42. Wang C, Xiao M, Liu X, Ni C, Liu J, Erben U, Qin Z*. 2013. IFN-gamma-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence.Cancer Res73: 1742-51

43. Rothe M, Quarcoo D, Chashchina AA, Bozrova SV,Qin Z, Nedospasov SA, Blankenstein T, Kammertoens T*, Drutskaya MS. 2013. IL-13 but not IL-4 signaling via IL-4Ralpha protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.Cancer Med2: 815-25

44. Deng J, Zhao X, Rong L, Li X, Liu X,Qin Z*.2013. TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy.Protein Cell4: 393-401

45. Zhao X, Rong L, Li X, Liu X, Deng J, Wu H, Xu X, Erben U, Wu P, Syrbe U, Sieper J,Qin Z*.2012. TNF signaling drives myeloid-derived suppressor cell accumulation.J Clin Invest122: 4094-104

46. Wu H, Tao N, Liu X, Li X, Tang J, Ma C, Xu X, Shao H, Hou B, Wang H,Qin Z*. 2012. Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells.PLoS One7: e51751

47. Li J, Chen L,Qin Z*.2012. Multifaceted tumor stromal fibroblasts.Cancer Microenviron5: 187-93

48. Kammertoens T,Qin Z,Briesemeister D, Bendelac A, Blankenstein T*. 2012. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-alpha, perforin).Int J Cancer131: 1499-508

49. Zhang J, Chen L, Xiao M, Wang C,Qin Z*.2011. FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation.Am J Pathol178: 382-90

50. Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, Chen J, Deng H,Qin Z*.2011. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection.J Mol Med(Berl) 89: 399-409

51. Lv J, Tao N, Wu H, Liu X, Xu X, Xu Y,Qin Z*.2011. Selective expansion and enhanced anti-tumor effect of antigen-specific CD4(+) T cells by retrovirus-mediated IL-15 expression.Protein Cell2: 585-99

52. Liu S, Rong L, Deng J, Zhao X, Liu X, Xu X,Qin Z*.2011. TNFR2 expression on non-bone marrow-derived cells is crucial for lipopolysaccharide-induced septic shock and downregulation of soluble TNFR2 level in serum.Cell Mol Immunol8: 164-71

53. Ding X, Yang W, Shi X, Du P, Su L,Qin Z*,Chen J*, Deng H*. 2011. TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms.J Immunol187: 1184-91

54. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G,Qin Z,Jiang Z*. 2011. Activation of STAT6 by STING is critical for antiviral innate immunity.Cell147: 436-46

55. Wang Z, Jiang J, Li Z, Zhang J, Wang H,Qin Z*.2010. A myeloid cell population induced by Freund adjuvant suppresses T-cell-mediated antitumor immunity.J Immunother33: 167-77

56. Li J, Lu Y, Zhang J, Kang H,Qin Z*,Chen C. 2010. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.Oncogene29: 2550-9

57. Jiang J, Wang Z, Li Z, Zhang J, Wang C, Xu X,Qin Z*.2010. Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression.Gene Ther17: 991-9

58. He XH, Zang Y, Chen X, Pang RP, Xu JT, Zhou X, Wei XH, Li YY, Xin WJ,Qin ZH,Liu XG*. 2010. TNF-alpha contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury.Pain151: 266-79

59. Xiao M, Wang C, Zhang J, Li Z, Zhao X,Qin Z*.2009. IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation.Cancer Res69: 2010-7

60. Lu Y, Yang W, Qin C, Zhang L, Deng J, Liu S,Qin Z*.2009. Responsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth via angiostasis.J Immunol183: 6413-21

61. Li Z, Chen L,Qin Z*.2009. Paradoxical roles of IL-4 in tumor immunity.Cell Mol Immunol6: 415-22

62. Li Z, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, Lu Y,Qin Z*.2008. Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.Cancer Res68: 8687-94

63. Kuprash DV*,Qin Z,Ito D, Grivennikov SI, Abe K, Drutskaya LN, Blankenstein T, Nedospasov SA. 2008. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice.Cancer Lett268: 70-5

64. Zhao X, Mohaupt M, Jiang J, Liu S, Li B,Qin Z*.2007. Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis.Cancer Res67: 4443-50

65. Li Z, Pradera F, Kammertoens T, Li B, Liu S,Qin Z*.2007. Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection.J Immunol179: 1568-76

66. Wu TH*, Pabin CN,Qin Z, Blankenstein T, Philip M, Dignam J, Schreiber K, Schreiber H. 2004. Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.J Immunol172: 3243-51

67.Qin Z, Blankenstein T*. 2004. A cancer immunosurveillance controversy.Nat Immunol5: 3-4; author reply -5

68. Kim HJ, Kammertoens T, Janke M, Schmetzer O,Qin Z, Berek C, Blankenstein T*. 2004. Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells.J Immunol172: 4037-47

69.Qin Z*,Schwartzkopff J, Pradera F, Kammertoens T, Seliger B, Pircher H, Blankenstein T. 2003. A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells.Cancer Res63: 4095-100

70. Guo J, Zhang M, Wang B, Yuan Z, Guo Z, Chen T, Yu Y,Qin Z, Cao X*. 2003. Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells.Int J Cancer103: 212-20

71. Guo J, Chen T, Wang B, Zhang M, An H, Guo Z, Yu Y,Qin Z, Cao X*. 2003. Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1.Immunol Lett89: 1-7

72. Blankenstein T,Qin Z*.2003. Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance.Adv Cancer Res90: 179-207

73. Blankenstein T,Qin Z*.2003. The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.Curr Opin Immunol15: 148-54

74. Yu Y, Liu S, Wang W, Song W, Zhang M, Zhang W,Qin Z, Cao X*. 2002. Involvement of tumour necrosis factor-alpha-related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharide-stimulated dendritic cells to activated T cells.Immunology106: 308-15

75.Qin Z*,Kim HJ, Hemme J, Blankenstein T. 2002. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction.J Exp Med195: 1479-90

76.Qin Z*,Harders C, Cao X, Huber C, Blankenstein T, Seliger B. 2002. Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors.Cancer Res62: 2856-60

77. Guo J, Wang B, Zhang M, Chen T, Yu Y, Regulier E, Homann HE,Qin Z, Ju DW, Cao X*. 2002. Macrophage-derived chemokine gene transfer results in tumor regression in murine lung carcinoma model through efficient induction of antitumor immunity.Gene Ther9: 793-803

78. An H, Yu Y, Zhang M, Xu H, Qi R, Yan X, Liu S, Wang W, Guo Z, Guo J,Qin Z, Cao X*. 2002. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells.Immunology106: 38-45

79. An H, Xu H, Yu Y, Zhang M, Qi R, Yan X, Liu S, Wang W, Guo Z,Qin Z, Cao X*. 2002. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways.Immunol Lett81: 165-9

80. Ibe S,Qin Z*,Schuler T, Preiss S, Blankenstein T. 2001. Tumor rejection by disturbing tumor stroma cell interactions.J Exp Med194: 1549-59

81. Cayeux S*,Qin Z, Dorken B, Blankenstein T. 2001. Decreased generation of anti-tumor immunity after intrasplenic immunization.Eur J Immunol31: 1392-9

82. Westermann J*, Kopp J, Korner I, Richter G,Qin Z, Blankenstein T, Dorken B, Pezzutto A. 2000. Bcr/abl+ autologous dendritic cells for vaccination in chronic myeloid leukemia.Bone Marrow Transplant25 Suppl 2: S46-9

83.Qin Z*,Blankenstein T. 2000. CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells.Immunity12: 677-86

84. Schuler T*,Qin Z, Ibe S, Noben-Trauth N, Blankenstein T. 1999. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice.J Exp Med189: 803-10

85. Westermann J*, Aicher A,Qin Z, Cayeux Z, Daemen K, Blankenstein T, Dorken B, Pezzutto A. 1998. Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation.Gene Ther5: 264-71

86. Uckert W*, Kammertons T, Haack K,Qin Z, Gebert J, Schendel DJ, Blankenstein T. 1998. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.Hum Gene Ther9: 855-65

87. Tong B, Grimes HL, Yang TY, Bear SE,Qin Z, Du K, El-Deiry WS, Tsichlis PN*. 1998. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.Mol Cell Biol18: 2462-73

88.Qin Z*,Richter G, Schuler T, Ibe S, Cao X, Blankenstein T. 1998. B cells inhibit induction of T cell-dependent tumor immunity.Nat Med4: 627-30

89. Petersson M*, Charo J, Salazar-Onfray F, Noffz G, Mohaupt M,Qin Z, Klein G, Blankenstein T, Kiessling R. 1998. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1.J Immunol161: 2099-105

90. Noffz G*,Qin Z, Kopf M, Blankenstein T. 1998. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors.J Immunol160: 345-50

91. Salazar-Onfray F*, Charo J, Petersson M, Freland S, Noffz G,Qin Z, Blankenstein T, Ljunggren HG, Kiessling R. 1997. Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.J Immunol159: 3195-202

92.Qin Z*,Noffz G, Mohaupt M, Blankenstein T. 1997. Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.J Immunol159: 770-6

93.Qin Z*,Blankenstein T. 1996. Influence of local cytokines on tumor metastasis: using cytokine gene-transfected tumor cells as experimental models.Curr Top Microbiol Immunol213 ( Pt 3): 55-64

94. Blankenstein T*,Qin Z*.1996. Cancer vaccines in gene therapy.Gene Ther3: 95-6

95. Blankenstein T*, Cayeux S, Qin Z. 1996. Genetic approaches to cancer immunotherapy.Rev Physiol Biochem Pharmacol129: 1-49

96.Qin Z*,van Tits LJ, Buurman WA, Blankenstein T. 1995. Human lymphotoxin has at least equal antitumor activity in comparison to human tumor necrosis factor but is less toxic in mice.Blood85: 2779-85

97.Qin Z*,Blankenstein T. 1995. Tumor growth inhibition mediated by lymphotoxin: evidence of B lymphocyte involvement in the antitumor response.Cancer Res55: 4747-51

98. Hock H, Dorsch M, Richter G, Kunzendorf U, Kruger-Krasagakes S, Blankenstein T,Qin Z, Diamantstein T*. 1994. Tumor-cell-targeted cytokine gene transfer in experimental models for cancer therapy.Nat Immun13: 85-92

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101. Hock H*, Dorsch M, Kunzendorf U,Qin Z, Diamantstein T, Blankenstein T. 1993. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.Proc Natl Acad Sci U S A90: 2774-8

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104.Qin ZH, Schuller I, Richter G, Diamantstein T, Blankenstein T*. 1991. The interleukin-6 gene locus seems to be a preferred target site for retrotransposon integration.Immunogenetics33: 260-6

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(From Zhihai Qin, November 16, 2020)