1986 - 1990 B.S., Nankai University, Tianjin, China

1990 - 1993 M.S., Beijing Normal University, Beijing, China

1993 - 1996 Ph.D., Peking University, Beijing, China

1996 - 1998 Assistant Professor, Institute of Biophysics, CAS

1998 - 2000 Associate Professor, Institute of Biophysics, CAS Visiting Scientist in the Institute of Food Research, Norwich, UK (The Royal Society K.C. Wong Research Fellowship)

2000 - Principle Investigator (PI ) (2004, full professor. Institute of Biophysics, CAS.)

2004 - 2005 Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK

2015 - Distinguished Professor, University of Chinese Academy of Sciences

2015 - Member, CAS Centre for Excellence in Biomacromolecules

2018.3 - 2018.8 Visiting Scientist, National Institute of Neurological Disorders and Stroke (NINDS), NIH.

2015 Special Government Allowances of the State Council

2014 Outstanding Contribution, CAS-Beijing

2012 National Outstanding Young Scientists

2006 Young Scientist Award Society for Free Radical Research (SFRR)-Asia

Vice Director of National Laboratory of Biomacromolecules

Professor of University of Chinese Academy of Sciences

Chief Scientist of "National Basic Research Program of China, 973 Program"

Chief Scientist of National Key R&D Program of China

President-elect of the International Society for Free Radical Biology of Asia

Council Member of the Society for Free Radical Research International (SFRRI) and American Free Radical Biology and Medicine (SFRBM)

Executive member of the council of The Biophysical Society of China

President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China

Council Member of the Chinese Society of Biochemistry and Molecular Biology

Vice President of the Beijing Society of Biochemistry and Molecular Biology

Vice President of the Commission for Aging Biology of the Biophysical Society of China

Associate Editor, Free Radical Biology & Medicine

Editorial Board Member, Redox Biology, Free Radical Research

Associate Editor, Biophysics Reports, Progress in Biochemistry and Biophysics

Annual review of research grants, National Natural Science Foundation of China; International Collaboration Projects, National Basic Research Program of China

Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as aging, cancer, atherosclerosis, neurodegenerative diseases, obesity, and diabetes. Our research has been focused on the crosstalk between these small molecules and macromolecules, trying to explore the relationship between protein function and cellular redox status. Based on it, try to find out effective approach to maintain cellular redox homeostasis and apply for good health. We are also interested in the working mechanism of traditional Chinese medicine (TCM) and its application.

The Ongoing Projects:

1.To explore Redox network - Redox map - Redox response: find out new redox genes, get the whole cell redox status map, illustrate the mechanism of redox regulation, particularly nitric oxide and S-nitros(yl)ation and other thiol modification in cellular quality control and physiopathology process.

2.To explore Redox stress and Aging: compare to the old Free radical theory of aging, we proposed that Redox-stress Response Capacity (RRC) is the key in aging process and it is under improvment. We are also interested in studying reductive stress and precision treatment in aging and aging related disease.

3.The working mechanism of traditional Chinese medicine (TCM) and its application, such as Goji (Lycium Barbarum) in aging.

4.Function, mechanism and the translational research of S-nitrosoglutathione reductase (GSNOR) and phosphatidylinositol 4-kinase type IIα (PI4KIIα).

1. Yang Q^#, Yan R^#, Zhang J^#, Zhang T, Kong Q, Zhang X, Xia H, Ye A, Qiao X, Kato K,Chen C*, An Y*. Reductive stress induced by NRF2/G6PD through glucose metabolic reprogramming promotes malignant transformation in Arsenite-exposed human keratinocytes.Sci Total Environ. 2023 Oct 20;896:165207.

2. Lv Z^#, Meng J^#, Yao S^#, Xiao F^#, Li S, Shi H, Cui C, Chen K, Luo X*, Ye Y*,Chen C*. Naringenin improves muscle endurance via activation of the Sp1-ERRγ transcriptional axis.Cell Reports. 2023 Oct 23;42(11):113288.

3. Qiao, X^#, Kang, L^#, Shi, C^#, Ye A^#, Wu D, Huang Y, Deng M, Wang J, Zhao Y*,Chen C*. Exploring the precision redox map during fasting-refeeding and satiation in C. elegans.Stress Biology. 2023 3, 17.

4. Guo M^#, Qiao X^#, Wang Y^#, Li Z#, Shi C, Chen Y, Kang L,Chen C*, Zhou X*. Mitochondrial translational defect extends lifespan in C. elegans by activating UPRmt.Redox Biol. 2023 July;63:102722.

5. Meng J, Wang Y, Lv Z, Qiao X, Ye A, Zhu Q,Chen C*. Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.Sci China Life Sci. 2023 Oct;66(10):2280-2294.

6. Meng J^#, Lv Z^#, Chen X^#, Sun C, Jin C, Ding K*,Chen C*. LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1.iScience. 2023, 106573.

7. Zhang H^#, Yu F^#, Xie P^#, Sun S^#, Qiao X^#, Tang S,Chen C, Yang S, Mei C, Yang D, Wu Y, Xia R, Li X, Lu J, Liu Y, Xie X, Ma D, Xu X, Liang Z, Feng Z, Huang X, Yu H, Liu G, Wang Y, Li J, Zhang Q, Chen C, Ouyang Y, Xie Q*. A Gγ protein regulates alkaline sensitivity in crops.Science. 2023 Mar 24;379(6638):eade8416.

8. Sun C^#, Chen X^#, Yang S, Jin C, Ding K*,Chen C*. LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRA/BMPRII/Noggin.Carbohyd Polym. 2023, 310: 120725.

9. Zhang W, Qiao X，Xie T, Cai W, Zhang X,Chen C*, Zhang Y. Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma.Antioxidants. 2023, 12, 81.

10. Gao L^#, Qiao X^#, Zhang L, Wang Y, Wan Y*,Chen C*. Nitric oxide inhibits alginate biosynthesis in Pseudomonas aeruginosa and increases its sensitivity to tobramycin by downregulating algU gene expression.Nitric Oxide. 2022 Aug 17:S1089-8603(22)00084-2.

11.陈畅*. 精准氧化还原调控.药学学报. 2022, 57(6): 1541-1543.

12. Zhang Y^#, Qiao X^#,*, Liu L^#, Han W, Liu Q, Wang Y, Xie T, Tang Y, Wang T, Meng J, Ye A, He S, Chen R*,Chen C*. Long noncoding RNA MAGI2-AS3 regulates the H₂O₂level and cell senescence via HSPA8.Redox Biol. 2022 Aug;54:102383.

13. Wang Y^#, Qiao X^#, Shi C^#, Ye A^#, Guo M, Zhao Y*,Chen C*. Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging[J].Prog Biochem Biophys. 2022, 49(3): 444-453.

14. Meng J^#, Lv Z^#, Guo M, Sun C, Li X, Jiang Z, Zhang W,Chen C*. ALycium barbarumextract inhibits β-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease.FASEB J. 2022 Feb;36(2):e22156.

15. Qiao X, Zhang Y, Ye A, Zhang Y, Xie T, Lv Z, Shi C, Wu D, Chu B, Wu X, Zhang W, Wang P, Liu GH, Wang CC, Wang L*,Chen C*. ER reductive stress caused by Ero1α S-nitrosation accelerates senescence.Free Radic Biol Med. 2022 Feb 20;180:165-178.

16. Xie T^#, Qiao X^#, Sun C^#, Chu B, Meng J,Chen C*. GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis.Nitric Oxide. 2021 Dec 29;120:1-8.

17. Meng J, Lv Z, Wang Y,Chen C*. Identification of the redox-stress signaling threshold (RST): Increased RST helps to delay aging inC. elegans.Free Radic Biol Med. 2021 Nov 27;178:54-58.

18. Cai WB, Zhao YJ, Liu L, Cheng Q, Wang J, Shi XL, Yao L, Qiao XH, Zhu Y,Chen C*, Zhang X*. Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury.Free Radic Biol Med. 2021 Jul 9;173:7-18.

19. Yi W^#, Zhang Y^#, Liu B^#,*, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z*,Chen C*, Ju Z*. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.Cell Rep. 2021 Mar 30;34(13):108922.

20. Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, Chen Y, Guo M, Han W, Ye A, Xie T, Chu B, Shi C, Yang S,Chen C*. Precision Redox: The Key for Antioxidant Pharmacology.Antioxid Redox Signal. 2021 May 10;34(14):1069-1082.

21. Meng J^#, Lv Z^#, Sun C, Qiao X,Chen C*. An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERRγ.FASEB J. 2020 Sep;34(9):11460-11473.

22. Yang J^#, Zhang H^#, Gong W^#, Liu Z, Wu H, Hu W, Chen X, Wang L, Wu S,Chen C*, Perrett S*. S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid.J Biol Chem. 2020 Jun 12;295(24):8302-8324.

23. Zheng WQ^#, Zhang Y^#, Yao Q^#, Chen Y^#, Qiao X, Wang ED*,Chen C*, Zhou XL*. Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation.Nucleic Acids Res. 2020 Jul 9;48(12):6799-6810.

24. Ban Y^#, Liu Y^#, Li Y, Zhang Y, Xiao L, Gu Y, Chen S, Zhao B,Chen C*, Wang N*. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.Redox Biol. 2019 Feb;21:101099.

25. Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X, Han L, Deng J, Fan F, Liu B, Huo Y, Xu Q,Chen C*, Wang X*, Feng J*. GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.Redox Biol. 2018 Jul;17:386-399.

26. Li J, Gao Z, Zhao D, Zhang L, Qiao X, Zhao Y, Ding H, Zhang P, Lu J, Liu J, Jiang H, Luo C*,Chen C*. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells.Cancer Res. 2017 Nov 15;77(22):6253-6266.

27. Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L,Chen C*. Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα.J Neurosci. 2017 Oct 4;37(40):9741-9758.

28. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P,Chen C*. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.Autophagy. 2017 Jul 3;13(7):1145-1160.

29. Ding Y^#, Li Y^#, Zhang X, He J, Lu D, Fang X, Wang Y, Wang J, Zhang Y, Qiao X, Gan LM,Chen C*, Zhu Y*. Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.J Mol Cell Cardiol. 2017 Sep;110:70-79.

30. Meng J, Lv Z, Qiao X, Li X, Li Y, Zhang Y,Chen C*. The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging.Redox Biol. 2017 Apr;11:365-374.

31. Zhang H, Yang J, Wu S, Gong W,Chen C*, Perrett S*. Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response.J Biol Chem. 2016 Mar 25;291(13):6967-81.

32. Gao L^#, Zhang Y^#, Wang Y, Qiao X, Zi J,Chen C*, Wan Y*. Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa.Redox Biol. 2016 Aug;8:252-8.

33. Yin R, Fang L, Li Y, Xue P, Li Y, Guan Y, Chang Y,Chen C*, Wang N*. Pro-inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation.Free Radic Biol Med. 2015 Dec;89:895-905.

34. Qiao, X, HU, M, Zhang, Y, Li Y,Chen, C*. Cellular redox regulation and thiol modification.Chinese Bulletin of Life Sciences. 2015 27(3), 374-382.

35. Zhou Q^#, Li J^#, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K*, Sun F*,Chen C*. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα.Nat Commun. 2014 Mar 28;5:3552.

36. Li J, Zhang L, Gao Z, Kang H, Rong G, Zhang X,Chen C*. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.Protein Cell. 2014 Jun;5(6):457-68.

37. Sun F, Li J,Chen C*. Puzzle out the regulation mechanism of PI4KIIα activity.Sci China Life Sci. 2014 Jun;57(6):636-8.

38. Wu K^#, Ren R^#, Su W^#, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte JC*, Liu GH*,Chen C*. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.J Biol Chem. 2014 Jul 18;289(29):20193-9.

39. Wu K, Zhang Y, Wang P, Zhang L, Wang T,Chen C*. Activation of GSNOR transcription by NF-κB negatively regulates NGF-induced PC12 differentiation.Free Radic Res. 2014 Sep;48(9):1011-7.

40. Hu M, Xu T*,Chen C*. Evaluation of the mitochondrial redox status inCaenorhabditis elegans: an assay based on the COPAS biosort flow cytometer.Acta Biophys Sin. 2014 30(2), 110-116.

41. Mao K^#, Chen S^#, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W,Chen C*, Meng G*, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.Cell Res. 2013 Feb;23(2):201-12.

42. Zhang X^#, Huang B^#, Zhang L, Zhang Y, Zhao Y, Guo X, Qiao X,Chen C*. SNObase, a database for S-nitrosation modification.Protein Cell. 2012 Dec;3(12):929-33.

43. Zhang X^#, Huang B^#,Chen C*. SNO spectral counting (SNOSC), a label-free proteomic method for quantification of changes in levels of protein S-nitrosation.Free Radic Res. 2012 Aug;46(8):1044-50.

44. Huang B,Chen C*. Function and Mechanism of Nitric Oxide (I)-Characteristics and Function.Acta Biophys Sin. 2012 28(3), 173-184.

45. Huang B,Chen C*. Function and Mechanism of Nitric Oxide (II)-Mechanism and Protein S-Nitrosation.Acta Biophys Sin. 2012 28(4), 268-277.

46. Hou Q^#, Jiang H^#, Zhang X, Guo C, Huang B, Wang P, Wang T, Wu K, Li J, Gong Z, Du L, Liu Y, Liu L*,Chen C*. Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila.Nitric Oxide. 2011 Jan 1;24(1):17-24.

47. Zhang X^#, Huang B^#, Zhou X,Chen C*. Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method.Protein Cell. 2010 Jul;1(7):675-87.

48. Huang B,Chen C*. Detection of protein S-nitrosation using irreversible biotinylation procedures (IBP).Free Radic Biol Med. 2010 Aug 1;49(3):447-56.

49. Zhou X, Han P, Li J, Zhang X, Huang B, Ruan HQ,Chen C*. ESNOQ, proteomic quantification of endogenous S-nitrosation.PLoS One. 2010 Apr 2;5(4):e10015.

50. Li J, Lu Y, Zhang J, Kang H, Qin Z*,Chen C*. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.Oncogene. 2010 Apr 29;29(17):2550-9.