1989 - 1993 B Sc, Huazhong University of Science and Technology

1993 - 1996 M Sc, Hubei Institute of Chemistry

1996 - 1999 Ph D, Institute of Biophysics, Chinese Academy of Sciences

1999 - 2001 Assistant Professor, Institute of Biophysics, Chinese Academy of Sciences

2001 - 2008 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2008 - Professor, Institute of Biophysics, Chinese Academy of Sciences

1999 President Fellowship of Chinese Academy of Sciences

Mitochondrion is the center for energy metabolism machinery, and the major checkpoint of apoptotic regulation. The homeostasis of mitochondrial network plays essential role in many cellular processes; its dysregulation has been linked to many diseases. We aim to use combined approaches to investigate the mechanism and regulation of the mitochondrial network, and their implication in various human diseases.

1. Boda Zhou, Min Xiao, Hao Hu, Xiaoxia Pei, Yajun Xue, Guobin Miao, Jifeng Wang, Wanqi Li, Yipeng Du, Ping Zhang* andTaotao Wei*. Cardioprotective role of SIRT5 in response to acute ischemia through a novel liver-cardiac crosstalk mechanism.Frontiers in Cell and Developmental Biology. 9(2021), 687559.

2. Jialing Zhang, Liang Yan, Peng Wei, Ruyi Zhou, Chaoju Hua, Min Xiao, Yaping Tu, Zhanjun Gu andTaotao Wei*. PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition.European Journal of Pharmacology, 895(2021), 173866.

3. Sheng Wang, Yan Xie, Yanwu Huo, Yan Li, Peter W. Abel, Haihong Jiang, Xiaohan Zou, Haizhan Jiao, Xiaolin Kuang, Dennis W. Wolff, Youguo Huang, Thomas B. Casale, Reynold A. Panettieri Jr.,Taotao Wei*, Zhengyu Cao* and Yaping Tu*. Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma.Science Signaling, 13(2020), eaax0273.（封面论文）

4. Jialing Zhang, Chaoju Hua, Yu Zhang, Peng Wei*, Yaping Tu* andTaotao Wei*. KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression.Cell Death and Disease11(2020), 732.

5. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye,Taotao Wei*and Ming Li*. Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation.Nano Letters19(2019), 6937-6944.

6. Peng Wei, Yan Xie, Peter W. Abel, Yapei Huang, Qin Ma, Linghai Li, Junfeng Hao, Dennis W. Wolff,Taotao Wei*and Yaping Tu*. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.Cell Death and Disease10(2019), 670.

7. Yang Xu, Jinqi Ren, Xiaolong He, Han Chen,Taotao Wei*and Wei Feng*. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.Autophagy15(2019), 1017-1030.

8. Yipeng Du, Hao Hu, Xiaoxia Pei, Kang Du andTaotao Wei*. Genetically encoded FapR-NLuc as a biosensor to determine Malonyl-CoA in situ at subcellular scales.Bioconjugate Chemistry30(2019), 826-832.

9. Yipeng Du*, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, JunfengHao, Pingsheng Liu, Fuquan Yang, Tingting Li* andTaotao Wei*.SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis inob/ob mice.EBioMedicine36(2018), 347-357.

10. Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, FugenShangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, DeyaoXie, Linhua Lan, XiangdongXue, Xingjie Liang, Bin Lv*,Taotao Wei*and Yan Qin*. Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch.Cancer Research78(2018), 2813-2824.

11. Bo Zhang, PengWei, Zhixiang Zhou andTaotao Wei*.Interactions of graphene with mammalian cells: Molecular mechanismsand biomedical insights.Advanced Drug Delivery Reviews105 (2016) 145–162.

12. Chuu-Yun A. Wong, Haihong Jiang, Peter W. Abel, Margaret A. Scofield, Yan Xie,Taotao Wei*and Yaping Tu*. Phorbolmyristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.Protein & Cell7(2016), 417-433.

13. Bo Zhang, Wei Chu, Peng Wei, Ying Liu andTaotao Wei*.Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I.Free Radical Biology & Medicine89(2015), 486-497.

14. Yipeng Du, Tanxi Cai, Tingting Li, Peng Xue, Bo Zhou, Xiaolong He, Peng Wei, Pingsheng Liu, Fuquan Yang* andTaotao Wei*.Lysine malonylation is elevated in type 2 diabeticmouse models and enriched in metabolicassociated proteins.Molecular & Cellular Proteomics14(2015), 227-236.

15. Teng Zhou, Meifang Yu, Bo Zhang, Liming Wang, Xiaochun Wu, Hejiang Zhou, Yipeng Du, JunfengHao, YapingTu, Chunying Chen* andTaotao Wei*.Inhibition of cancer cell migration by gold nanorods: molecular mechanisms and implications for cancer therapy.Advanced Functional Materials24(2014), 6922-6932.

16. Qianqian Chen, Juan Zhang, Kai Zhao, Wei Li, Qi Miao, Yang Sun, Xingyu Zhao,Taotao Wei*and Fuyu Yang*. Lysosomal chymotrypsin inducesmitochondrial fission in apoptotic cellsby proteolytic activation of calcineurin.Protein & Cell5(2014), 643-647.

17. Yipeng Du andTaotao Wei*. Inputs and outputs of insulin receptor.Protein & Cell5(2014), 203-213.

18. Teng Zhou, Bo Zhang, Peng Wei, Yipeng Du, Hejiang Zhou, Meifang Yu, Liang Yan, Wendi Zhang, Guangjun Nie, Chunying Chen, Yaping Tu andTaotao Wei*. Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.Biomaterials35(2014), 9833-9843.

19. Hejiang Zhou, Bo Zhang, Jiajia Zheng, Meifang Yu, Teng Zhou, Kai Zhao, YanxiaJia, Xingfa Gao*, Chunying Chen* andTaotao Wei*.The inhibition of migration and invasion of cancer cells by graphenevia the impairment of mitochondrial respiration.Biomaterials35(2014), 1597-1607.

20. Wenjuan Duan, Juefei Zhou, Wei Li, Teng Zhou, Qianqian Chen, Fuyu Yang* andTaotao Wei*.Plasma membrane calcium ATPase 4binhibits nitric oxide generation throughcalcium-induced dynamic interaction withneuronal nitric oxide synthase.Protein & Cell4(2013), 286-298.

21. Kai Zhao, Hejiang Zhou, Xingyu Zhao, Dennis W. Wolff, YapingTu, Huili Liu,Taotao Wei*and Fuyu Yang*. Phosphatidic acid mediates the targeting of tBid toinduce lysosomal membrane permeabilizationand apoptosis.Journal of Lipid Research53(2012), 2102-2114.

22. Hejiang Zhou, Kai Zhao, Wei Li, Na Yang, Ying Liu, Chunying Chen* andTaotao Wei*.The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways.Biomaterials33(2012), 6933-6942.

23. Wei Li, Lina Zhao,Taotao Wei*,Yuliang Zhao* and Chunying Chen*. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles.Biomaterials32(2011), 4030-4041.

24. Kai Zhao, Xingyu Zhao, YapingTu, Qi Miao, Dongxu Cao, WenjuanDuan, Yang Sun, Jincheng Wang,Taotao Wei*and Fuyu Yang*. Lysosomal chymotrypsin B potentiates apoptosis via cleavageof Bid.Cellular and Molecular Life Sciences67(2010), 2665-2678.

(From Taotao Wei, October 29, 2021)