2000 - 2004 B.S., Xinyang Normal University

2004 - 2010 Ph.D., Wuhan University

2010 - 2015 Postdoctoral fellows, University of California, San Diego

2015 - Professor, Institute of Biophysics, Chinese Academy of Sciences

2016 - Professor, University of Chinese Academy of Sciences

2022 WuXi AppTec Life Sciences Award

2021 VCANBIO Award for innovations and breakthroughs in life sciences and medicine

2021 Outstanding Mentor Award of the Chinese Academy of Sciences

2021 Lingyan Silver Award of the University of the Chinese Academy of Sciences

2020 Outstanding Mentor Award of the Chinese Academy of Sciences

2020 National Distinguished Youth Science Fund

2015 National Outstanding Youth Science Fund

2015 Overseas High-Level Talent Program

1. The functional mechanism of noncoding RNAs.

2. RNA binding proteins in transcriptional regulation.

3. Developing new technology for studying protein-RNA interactions.

1. Rong Ye^#, Naijing Hu^#, Changchang Cao, Ruibao Su, Shihan Xu, Chen Yang, Xiangtian Zhou,Yuanchao Xue*. Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation.Mol Cell, 2023, S1097-2765(23)00158-2.

2. Jing Guo^#, Hailian Zhao^#, Jue Zhang^#, Xiangjiang Lv, Shen Zhang, Ruibao Su, Wei Zheng, Jing Dai, Fei Meng, Fei Gong, Guangxiu Lu,Yuanchao Xue*, Ge Lin*. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.Adv Sci., 2023 Feb 8; e2205500.

3. Yue Lv^#, Gang Lu^#, Yuling Cai^#, Ruibao Su^#, Liang Liang, Xin Wang, Wenyu Mu, Xiuqing He, Tao Huang, Jinlong Ma, Yueran Zhao, Zi-Jiang Chen*,Yuanchao Xue*, Hongbin Liu*, Wai-Yee Chan*. RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.Protein Cell. 2022 Sep 14;14(1):51-63.

4.Yuanchao Xue*. Architecture of RNA-RNA interactions.Curr Opin Genet Dev. 2022, 72:138-144 (Invited review).

5. Di Wang^#, Rong Ye^#, Zhaokui Cai,Yuanchao Xue*. Emerging roles of RNA-RNA interactions in transcriptional regulation (Invited review).WIRES RNA., 2022, 18:e1712.

6. Changchang Cao^#, Zhaokui Cai^#, Xia Xiao^#, Jian Rao, Juan Chen, Naijing Hu, Minnan Yang, Xiaorui Xing, Yongle Wang, Manman Li, Bing Zhou, Xiangxi Wang, Jianwei Wang*,Yuanchao Xue*. The architecture of the SARS-CoV-2 RNA genome inside virion.Nat Commun., 2021, 12(1): 3917.

7. Changchang Cao^#, Zhaokui Cai^#, Rong Ye, Ruibao Su, Naijing Hu, Hailian Zhao,Yuanchao Xue*. Global in situ profiling of RNA-RNA spatial interactions with RIC-seq.Nat Protoc., 2021, 16(6): 2916-2946.

8. Ruibao Su^#, Li-Hua Fan^#, Changchang Cao^#, Lei Wang, Zongchang Du, Zhaokui Cai, Ying-Chun Ouyang, Yue Wang, Qian Zhou, Ligang Wu, Nan Zhang, Xiaoxiao Zhu, Wen-Long Lei, Hailian Zhao, Yong Tian, Shunmin He, Catherine C L Wong*, Qing-Yuan Sun*,Yuanchao Xue*. Global profiling of RNA-binding protein target sites by LACE-seq.Nat Cell Biol., 2021, 23(6): 664-675.

9. Zhaokui Cai^#, Changchang Cao^#, Lei Ji^#, Rong Ye, Di Wang, Cong Xia, Sui Wang, Zongchang Du, Naijing Hu, Xiaohua Yu, Juan Chen, Lei Wang, Xianguang Yang, Shunmin He,Yuanchao Xue*. RIC-seq for global in situ profiling of RNA-RNA spatial interactions,Nature, 2020, 582, 432-437.

10. Juan Chen^#, Zhaokui Cai^#, Meizhu Bai^#, Xiaohua Yu^#, Chao Zhang^#, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Lei Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li,Yuanchao Xue*. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.Cell Res., 2018, 28: 981-995. (Cover; featured in Research Highlight).

11. Jinyang Zhang^#, Lingling Hou^#, Zhenqiang Zuo^#, Peifeng Ji, Xiaorong Zhang,Yuanchao Xue, Fangqing Zhao*. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long.Nat Biotechnol., 2021, 39(7):836-845.

12.Yuanchao Xue, Runsheng Chen*, Lianghu Qu*, Xiaofeng Cao*. Noncoding RNA: from dark matter to bright star.Science China Life sciences, 2020, 63, 463-468.

13. Rong Ye, Changchang Cao,Yuanchao Xue*. Enhancer RNA: biogenesis, function, and regulation.Essays Biochem, 2020, 64(6): 883-894.

14.Yuanchao Xue^#, *, Hao Qian^#, Jing Hu, Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-Dong Fu*. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells.Nat Neurosci., 2016, 19(6):807-15.

15. Juan Chen^#,Yuanchao Xue*. Emerging roles of non-coding RNAs in epigenetic regulation.Sci China Life Sci. 2016;59(3):227-35.

16.Yuanchao Xue, Kunfu Ouyang, Jie Huang, Yu Zhou, Hong Ouyang, Hairi Li, Gang Wang, Qijia Wu, Chaoliang Wei, Yanzhen Bi, Li Jiang, Zhiqiang Cai, Hui Sun, Kang Zhang, Yi Zhang, Ju Chen, Xiang-Dong Fu*. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.Cell. 2013, 152(1-2):82-96.

17.Yuanchao Xue^#, Yu Zhou^#, Tongbin Wu, Tuo Zhu, Xiong Ji, Young-SooKwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu*, Yi Zhang*. Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping.Mol Cell, 2009, 36(6):996-1006. (Cover; featured in Preview)

(From Yuanchao Xue, April 11, 2023)