2006 - 2010 B.S., Dezhou University, Biophysics

2010 - 2011 Ph.D, University of Science and Technology of China

2011 - 2015 Ph.D, Institute of Biophysics (IBP), Chinese Academy of Sciences

2015 - 2019 Postdoctoral Fellow, Oregon Health & Science University

2020 - Principal Investigator, CAS Institute of Biophysics 　

Structure and Function of Membrane Protein.

1. Z. Zhang^#, H. Chen^#, Z. Geng^#, Z. Yu, H. Li, Y. Dong, H. Zhang, Z. Huang*, J. Jiang*,Y. Zhao*.Structural basis of ligand binding modes of human EAAT2.Nature Communications.2022 Jun 9;13(1):3329.

2. Y. Dong^#, H. Li^#, A. Ilie^#, Y. Gao, A. Boucher, X. C. Zhang*, J. Orlowski*,Y. Zhao*.Structural basis of autoinhibition of the human NHE3-CHP1 complex.Science advances. 2022 May 27;8(21):eabn3925.

3. L. He^#, Z. Yu^#, Z. Geng^#, Z. Huang^#, C. Zhang, Y. Dong, Q. Chen, L. Sun, X. Ma, B. Huang, X. Wang,Y. Zhao*.Structure, gating and pharmacology of human CaV3.3 channel.Nature Communications. 2022 Apr 19;13(1):2084.

4. X. Li^#, F. Xu^#, H. Xu^#, S. Zhang, Y. Gao, H. Zhang, Y. Dong, Y. Zheng, B. Yang, J. Sun, X. C. Zhang,Y. Zhao*, D. Jiang*. Structural basis for modulations of human NaV by clinical drug and selective antagonist.Nature Communications. 2022 Mar 11;13(1):1286.

5. H. Zhang^#, J. Su^#, B. Li^#, Y. Gao, M. Liu, L. He, H. Xu, X. C. Zhang,Y. Zhao*. Structure of human glycosylphosphatidylinositol transamidase.Nature Structural & Molecular Biology. 2022: 1-7

6. Yanli Dong^#, Yiwei Gao^#, Shuai Xu^#Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Bei Yang, Xuejun Cai Zhang, Daohua Jiang*, Zhuo Huang*,Y. Zhao*. Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2.Cell Reports. 2021. 37, 109931.

7. Lingli He^#, Jiahui Sun^#, Yiwei Gao^#, Bin Li, Yuhang Wang, Yanli Dong, Weidong An, Hang Li, Bei Yang, Yuhan Ge, Xuejun Cai Zhang*, Yun Stone Shi* &Y. Zhao*. Kainate receptor modulation by NETO2.Nature. 2021.

8. Yanli Dong^#, Yiwei Gao^#, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang*, John Orlowski* &Y. Zhao*. Structure and mechanism of the human NHE1-CHP1 complex.Nature Communications. 2021. 9;12(1):3474.

9. Rong Y, Jiang J.H, Gao Y.W, Guo J.L, Song D.F, Liu W.H, Zhang M.M,Zhao Y*, Xiao B.L*, Liu Z.F*. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.Elife.2021.10, e71474.

10.Y. Zhao, S. Chen, A. C. Swensen, W. J. Qian, E. Gouaux. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.Science. 2019. 364, 355-362.

11. Y. Xin,Y. Zhao, J. Zheng, H. Zhou, X. C. Zhang, C. Tian, & Y. Huang. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion.The FASEB Journal. 2018. 32(5), 2411-2421.

12. S. Chen^#,Y. Zhao^#, Y. Wang, M. Shekhar, E. Tajkhorshid and E. Gouaux. Activation and desensitization mechanism of AMPA receptor - TARP complex by cryo-EM.Cell. 2017.170, 1234-1246.

13.Y. Zhao^#, S. Chen^#, C. Yoshioka, I. Baconguis, E. Gouaux. Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.Nature. 2016.536(7614): 108-111.　　

14. G. Mao^#,Y. Zhao^#, X. Kang, Z. Li, Y. Zhang, X. Wang, F. Sun, K. Sankaran and XC. Zhang. Crystal structure ofE. colilipoprotein diacylglyceryl transferase.Nature communications. 2016.7: 10198.　　

15. J. Heng,Y. Zhao, M. Liu, Y. Liu, J. Fan, X. Wang, Y. Zhao, and XC. Zhang. Substrate-bound structure of theE. colimultidrug resistance transporter MdfA.Cell research. 2015.25(9): 1060. 　　

16. X.C. Zhang,Y. Zhao, J. Heng, D. Jiang. Energy coupling mechanisms of MFS transporters.Protein Science. 2015.24(10): 1560-1579.　

17.Y. Zhao^#, G. Mao^#, M. Liu, L. Zhang, X. Wang, X.C. Zhang. Crystal structure of theE. colipeptide transporter YbgH.Structure. 2014.22(8): 1152-1160.　　

18. B. Cao^#,Y. Zhao^#, Y. Kou, D. Ni, X.C. Zhang and Y. Huang. Structure of the nonameric bacterial amyloid secretion channel.Proceedings of the National Academy of Sciences. 2014.111(50): E5439-E5444.　　　

19. D. Jiang^#,Y. Zhao^#, J. Fan, X. Liu, Y. Wu, W. Feng, X.C. Zhang. Atomic resolution structure of theE. coliYajR transporter YAM domain.Biochemical and biophysical research communications. 2014.450(2): 929-935.　　

20. S. Qiao, Q. Luo,Y. Zhao, X.C. Zhang, Y. Huang. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane.Nature. 2014.511(7507): 108.

21. J. Fan, D. Jiang,Y. Zhao, J. Liu, and X.C. Zhang. Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B.Proceedings of the National Academy of Sciences. 2014.111(21): 7636-7640. 　　

22. D. Jiang^#,Y. Zhao^#, X. Wang^#, J. Fan, J. Heng, X. Liu, W. Feng, X. Kang, B. Huang, J. Liu and X.C. Zhang. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A.Proceedings of the National Academy of Sciences. 2014.110(36): 14664-14669.　　

23. W. Zhang, F. Zeng, Y. Liu,Y. Zhao, H. Lv, L. Niu, M. Teng and X. Li (2013). Crystal Structures and RNA-Binding Properties of the RRMs of hnRNP-L: Insights into Its Roles in Alternative-splicing Regulation.Journal of Biological Chemistry. 2014 288(31), 22636-22649.

(From Yan Zhao, September 22, 2022)