1994 - 1997 BS in Veterinary, Hebei Agriculture University

1997 - 2000 MS in Veterinary Microbiology and Immunology, Nanjing Agricultural University

2000 Ph.D. in Virology, Chinese Academy of Preventive Medicine (CAPM)

2000 - 2002 Assistant Professor, Institute of Virology, Chinese Academy of Preventive Medicine (CAPM)

2002 - 2004 Post Doc associate, School of Medicine, Yale University

2004 - 2008 Post Doc associate, School of Medicine, University of North Carolina

2008 - Principle investigator, Institute of Biophysics, CAS

2005 - 2006 AmFAR fellowship (The Foundation for AIDS Research)

1. HIV pathogenesis in a Humanized mice model with human immune system.

2. Developing humanized mice model with human immune system and liver for studying HBV and HCV infection and imunopathogenesis.

3. Plasmacytoid dendritic cells and its role in viral infection.

Research papers

1. Cheng L, Ma J, Li J, Li D, Li G, Li F, Zhang Q, Yu H, Yasui F, Ye C, Tsao LC, Hu Z, Su L,Zhang L(2017) Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs.J Clin Invest127(1):269-279.

2. Zhang X, Yang P, Wang N, Zhang J, Li J, Guo H, Yin X, Rao Z, Wang X,Zhang L(2017) The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.Protein Cell8(8):590-600.

3. Yin X, Yu H, Jin X, Li J, Guo H, Shi Q, Yin Z, Xu Y, Wang X, Liu R, Wang S,Zhang L(2017) Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions.J Immunol198(4):1553-1564.

4. Li J1, Du Q, Hu R, Wang Y, Yin X, Yu H, Du P, Plumas J, Chaperot L, Liu YJ,Zhang L(2016) Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production.Protein Cell7(4):291-4. doi: 10.1007/s13238-015-0239-0.

5. Ma J, Yu H, Yin X, Cheng M, Shi Q, Yin Z, Nie X, Shouli W,Zhang L(2015) E2-2, a novel immunohistochemical marker for both human and monkey plasmacytoid dendritic cells.Biophys Rep1:139-147. doi: 10.1007/s41048-016-0023-6. Epub 2016 Apr 11

6. Guo H, Zhang J,Zhang X, andZhang L(2015) SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7.J Immunol194(10): 4737–4749.

7. Cheng M, Zhang X, Yu H, Du P, Plumas J, Chaperot L, Su L,Zhang L(2015) Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells.Sci Rep17;5:10752. doi: 10.1038/srep10752.

8. Li G, Cheng M, Nunoya J, Cheng L, Guo H, Yu H, Liu YJ, Su L &Zhang L(2014) Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice.PLoS Pathog10, e1004291.

9. Hu R, Du Q, Yin X, Li J, Wang T &Zhang L(2014) Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment.FEBS Lett588, 401-407.

10. Yang D, Liu L, Zhu D, Peng H, Su L, Fu YX &Zhang L(2014) A mouse model for HBV immunotolerance and immunotherapy.Cell Mol Immunol11, 71-78.

11. Li F, Cowley DO, Banner D, Holle E,Zhang L& Su L (2014) Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology.Sci Rep4, 5290.

12. Dang M, Wang X, Wang Q, Wang Y, Lin J, Sun Y, Li X,Zhang L, Lou Z, Wang J, et al. (2014) Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71.Protein Celldoi: 10.1007/s13238-014-0087-3.

13. Bility MT, Cheng L, Zhang Z, Luan Y, Li F, Chi L,Zhang L, Tu Z, Gao Y, Fu Y, Su L. (2014) Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages.PLoS Pathog10, e1004032.

14. Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W,Zhang L, Hung LW, Matsugaki N, Wakatsuki S, et al. (2012) S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.Acta Crystallogr D Biol Crystallogr68, 521-530.

15. Ma JP, Xia HJ, Zhang GH, Han JB,Zhang L& Zheng YT (2012) Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques.Cell Mol Immunol9(5):410-6.

16. Bility MT,Zhang L, Washburn ML, Curtis TA, Kovalev GI & Su L (2012) Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis.Nat Protoc7, 1608-1617.

17. Du Q, Jiao Y, Hua W, Wang R, Wei F, Ji Y, Du P, Liu YJ, Wu H &Zhang L(2011) Preferential depletion of CD2(low) plasmacytoid dendritic cells in HIV-infected subjects.Cell Mol Immunol8, 441-444.

18.Zhang L, Jiang Q, Li G, Jeffrey J, Kovalev GI & Su L (2011) Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2(-)/(-)gamma C(-)/(-) mice in vivo.Blood117, 6184-6192.

19. Washburn ML, Bility MT,Zhang L, Kovalev GI, Buntzman A, Frelinger JA, Barry W, Ploss A, Rice CM & Su L (2011) A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.Gastroenterology140, 1334-1344.

20. Sivaraman V,Zhang L& Su L (2011) Type I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus.J Virol85, 9243-9246.

21. Ince WL,Zhang L, Jiang Q, Arrildt K, Su L & Swanstrom R (2010) Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model.J Virol84, 2740-2752.

22. Sivaraman V,Zhang L, Meissner EG, Jeffrey JL & Su L (2009) The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env.J Virol83, 11715-11725.

23. Choudhary SK, Rezk NL, Ince WL, Cheema M,Zhang L, Su L, Swanstrom R, Kashuba AD & Margolis DM (2009) Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse.J Virol83, 8254-8258.

24. Jiang Q,Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D & Su L (2008) FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.Blood112, 2858-2868.

25. Holmes D, Jiang Q,Zhang L& Su L (2008) Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis.Immunol Res41, 248-266.

26.Zhang L, Kovalev GI & Su L (2007) HIV-1 infection and pathogenesis in a novel humanized mouse model.Blood109, 2978-2981.

27. Meissner EG,Zhang L, Jiang S & Su L (2006) Fusion-induced apoptosis contributes to thymocyte depletion by a pathogenic human immunodeficiency virus type 1 envelope in the human thymus.J Virol80, 11019-11030.

28. Farr GA,Zhang L& Tattersall P (2005) Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry.Proc Natl Acad Sci U S A102, 17148-17153.

Invited Reviews

1.Zhang L& Su L (2012) HIV-1 immunopathogenesis in humanized mouse models.Cell Mol Immunol9, 237-244, doi: 10.1038/cmi.2012.7.

2.Zhang L, Meissner E, Chen J & Su L (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Sci China Life Sci53, 195-203, doi: 10.1007/s11427-010-0059-7 [doi].

(From Liguo Zhang, December 12, 2020)