1994 - 1998 B.S., Dept. of Special Class for Gifted Young (Advisor: Prof. Zuyao Chen) Univ. of Science and Technology of China

1998 - 2003 Ph.D., Dept. of Chemistry (Advisor: Prof. Kenneth S. Suslick) Univ. of Illinois at Urbana-Champaign

2003 - 2007 Postdoctoral training, Dept. of Chemistry (Advisor: Prof. Peter G. Schultz) The Scripps Research Institute

2007 - Professor, Institute of Biophysics, Chinese Academy of Sciences

2013 The 13th China Youth Science and Technology Award

2013 National Outstanding Young Scientists

2014 Asian Photochemical Society Young Scientist Award

2015 Cheung Kong Scholar Young Scholar of the Ministry of Education

2015 Beijing Science and Technology Award

2015 Young top-notch talents of the Organization Department of the Central Committee of the Communist Party of China

2016 The 5th Chinese Chemical Society/Royal Society Young Chemist Award

2016 Young and middle-aged scientific and technological innovation leading talents in the innovative talent promotion plan

2018 National High-level Talents Special Support Program Leading Talents

2018 Special Government Allowances of the State Council

1. Protein and RNA site-specific labeling chemical biology, applied to protein nucleic acid drug modification and optimization, light microscope and electron microscope imaging.

2. Enzyme chemical biology and synthetic biology, applied to the prevention and control of pathogenic microorganisms, artificial photosynthesis, carbon neutrality and other fields.

3. G-protein coupled receptor mechanism research and synthetic biology research, applied to active health and disease diagnosis and treatment.

• Important research progress in the past five years




1. In 2020, WANG Jiangyun's Group Makes Progress in Studying the Preference of GPCR Signal Transduction

//www.wyreworks.com/kyjz/2020kyjz2/202009/t20200930_5710016.html

2. In 2021, the research group of Professor Wang Jiangyun/Zhong Fangrui and Wu Yuzhou made important progress in the design of biocatalytic cross-coupling-light-driven halogenated aromatic hydrocarbon hydroxylation dehalogenase

//www.wyreworks.com/kyjz/2021kyjz/202101/t20210108_5853979.html

3. In 2021, Wang Jiangyun/Li Yunliang/Zhuang Wei's research group made important progress in the study of the flexibility of enzyme active centers with gene-encoded two-dimensional infrared probes

//www.wyreworks.com/kyjz/2021kyjz/202103/t20210301_5963635.html

4. Professor WANG Jiangyun's research group and collaborators made the new progress in the study of the phosphorylation barcode mechanism of G protein coupled receptor

//www.wyreworks.com/kyjz/2021kyjz/202105/t20210531_6046213.html

5. In 2021, Wang Jiangyun/Tian Changlin's research group made important progress in the rational design of photocatalytic CO2 reductase

//www.wyreworks.com/kyjz/2021kyjz/202104/t20210425_5996822.html

6. In 2021, Wang Jiangyun's research team and collaborators have made significant progress in the study of the conformational distribution of arrestin, a downstream protein regulated by GPCRs detected by smFRET

//www.wyreworks.com/kyjz/2021kyjz/202106/t20210608_6080508.html

7. In 2021, Wang Jiangyun/Xia Andong/Yu Longjiang's research group made important progress in the rational design of photosensitive proteins for efficient photoinduced electron transfer

//www.wyreworks.com/kyjz/2021kyjz/202106/t20210616_6108414.html

8. In 2021, Wang Jiangyun/Liu Zhijie/Hua Tian's research group will make important progress in the study of GPCR allosteric regulation mechanism

//www.wyreworks.com/kyjz/2021kyjz/202110/t20211008_6219306.html

9. In 2022, Wang Jiangyun/Chen Yongxiang's research group made important progress in genetically encoded phosphine ligand for metalloprotein design.

//www.wyreworks.com/kyjz/2022kyjz/202211/t20221124_6554199.html

10. In 2023, Wang Jiangyun/Dong Min's research group made important progress in genetically encoded photosensitizer protein reduces Iron-Sulfur clusters of radical SAM enzymes.

//www.wyreworks.com/kyjz/zxdt/202305/t20230506_6749693.html

11. In 2023, Wang Jiangyun/Zhong Fangrui's research group made important progress in the whole-cell-catalyzed hydrogenation/deuteration of aryl halides with a genetically repurposed photodehalogenase.

//www.wyreworks.com/kyjz/zxdt/202304/t20230406_6727752.html

12. In 2024, Wang Jiangyun's research group made important progress in fenofibrate recognition and Gq protein coupling mechanisms of the human cannabinoid receptor CB1.

//www.wyreworks.com/kyjz/zxdt/202402/t20240205_6985875.html

13. In 2024, Wang Jiangyun's research group made important progress in the study of the molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.

//www.wyreworks.com/kyjz/zxdt/202401/t20240110_6951562.html

14. In 2024, Wang Jiangyun's research group made important progress in the molecular activation and G-protein coupling selectivity of the human succinate receptor SUCR1.

//www.wyreworks.com/kyjz/zxdt/202405/t20240516_7162787.html

1. Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F*,Wang J*. Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1.Cell Research. 2024, 0:1-4, DOI: 10.1038/s41422-024-00968-7

2. Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F*,Wang J*. Fenofibrate Recognition and Gq Protein CouplingMechanisms of the Human Cannabinoid Receptor CB1.Adv. Sci. 2024, 2306311，DOI: 10.1002/advs.202306311

3. Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X,Wang J*. Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.Cell Research. 2024 ,34, 323-326, DOI: 10.1038/s41422-023-00914-z

4. Fu Y, Liu X, Xia Y, Guo X, Guo J, Zhang J, Zhao W, Wu Y,Wang J*, and Zhong F*. Whole-cell-catalyzed hydrogenation/deuteration of aryl halides with a genetically repurposed photodehalogenases,Chem. 2023, 9, 1897-1909, DOI: 10.1016/j.chempr.2023.03.006

5. Huang R, Zhi N, Yu L, Li Y, Wu X, He J, Zhu H, Qiao J, Liu, X, Tian C,Wang J*, and Dong M*. Genetically Encoded Photosensitizer Protein Reduces Iron?Sulfur Clusters of Radical SAM Enzymes,ACS Catal. 2023, 13, 1240?1245, DOI: 10.1021/acscatal.2c05143

6. Xu C, Zou Q, Tian J, Li M, Xing B, Gong J,Wang J*, Huo Y*, Guo S*. Simplified Construction of Engineered Bacillus subtilis Host for Improved Expression of Proteins Harboring Noncanonical Amino Acids,ACS Synth. Biol. 2023, 12, 583?595, DOI: 10.1021/acssynbio.2c00604

7. Duan H, Hu C, Li Y, Wang S, Xia Y, Liu X*,Wang J*, Chen Y*. Genetically Encoded Phosphine Ligand for Metalloprotein Design,J. Am. Chem. Soc. 2022, 144, 22831?22837, DOI:10.1021/jacs.2c09683

8. Liu X, Liu P, Li H, Xu Z, Jia L, Xia Y, Yu M, Tang W, Zhu X, Chen C, Zhang Y, Nango E, Tanaka R, Luo F, Kato K, Nakajima Y, Kishi S, Yu H, Matsubara N, Owada S, Tono K, Iwata S, Yu L*, Shen J*,Wang J*. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.Nat Chem. 2022, 14(9):1054-1060. DOI: 10.1038/s41557-022-00992-3.

9. Wang P, Zhang G, Xu Z, Chen Z, Liu X, Wang C, Zheng C,Wang J*, Zhang H*, Yan A*. Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria.J Biol Chem. 2022, 298(8):102258. DOI: 10.1016/j.jbc.2022.102258.

10. Yang K, Yu M, Zhu X, Xia Y, Li F, Li Y, Liu X*,Wang J*. Genetic Incorporation of Fluorescent Amino Acid into Fatty Acid Binding Protein for Fatty Acid Detection.Journal of Molecular Biology. 2022, 434(8): 167498. DOI: 10.1016/j.jmb.2022.167498

11. Han Y, Guo X, Zhang T,Wang J*, Ye K*. Development of an RNA-protein crosslinker to capture protein interactions with diverse RNA structures in cells.RNA. 2022, 28(3):390-399. DOI: 10.1261/rna.078896.121.

12. Cheng R, Lai R, Peng C, Lopez J, Li Z, Naowarojna N, Li K, Wong C, Lee N, Whelan SA, Qiao L, Grinstaff M,Wang J, Cui Q*, and Liu P*. Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C-S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis.ACS Catal. 2021, 11, 6, 3319-3334. DOI: https://doi.org/10.1021/acscatal.0c04886

13. Wang X, Liu D, Shen L, Li F, Li Y, Yang L, Xu T, Tao H, Yao D, Wu L, Hirata K, Bohn L, Makriyannis A, Liu X, Hua T*, Liu Z*, andWang J*. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.J. Am. Chem. Soc. 2021, 143, 40, 16320-16325. DOI: 10.1021/jacs.1c06847

14. Zheng D, Tao M, Yu L, Liu X*, Xia A*,Wang J*. Ultrafast Photoinduced Electron Transfer in a Photosensitizer Protein.CCS Chem. 2021, 3, 1580-1586. DOI: 10.31635/ccschem.021.202100823

15. Han M, He Q, Yang M, Chen C, Yao Y, Liu X, Wang Y, Zhu Z, Zhu K, Qu C, Yang F, Hu C, Guo X, Zhang D, Chen C*, Sun J* andWang J*. Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and Se-Click reaction.Chemical Science, 2021,12, 9114-9123, DOI: 10.1039/D1SC02653D

16. Wu E, Guo X, Teng X, Zhang R, Li F, Cui Y, Zhang D, Liu Q, Luo J*,Wang J*, Chen R*. Discovery of Plasma Membrane-Associated RNAs through APEX-seq.Cell Biochem Biophys. 2021, 79, 905-917. DOI: https://doi.org/10.1007/s12013-021-00991-0

17. Wang Y, Liu P, Chang J, Xu Y*,Wang J*. Site-specific selenocysteine incorporation into proteins by genetic engineering.ChemBioChem. 2021, 22, 2918 -2924. DOI: https://doi.org/10.1002/cbic.202100124

18. He Q, Xiao P, Huang S, Jia Y, Zhu Z, Lin J, Yang F, Tao X, Zhao R, Gao F, Niu X, Xiao K,Wang J*, Jin C*, Sun J*& Yu X*. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2.Nat Commun2021,12, 2396. DOI: https://doi.org/10.1038/s41467-021-22731-x

19. Wang L, Zhang J , Han M, Zhang L, Chen C, Huang A, Xie R, Wang G, Zhu J, Wang Y, Liu X*, Zhuang W*, Li Y*,Wang J*. A Genetically Encoded Two-Dimensional Infrared Probe for Enzyme Active-Site Dynamics.Angew Chem Int Ed Engl. 2021, 60, 11143 -11147. DOI: https://doi.org/10.1002/anie.202016880

20. Fu Y, Huang J, Wu Y*, Liu X*, Zhong F*, andWang J*. Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase.J. Am. Chem. Soc. 2021, 143, 2, 617-622. DOI: 10.1021/jacs.0c10882

21. Kang F, Yu L, Xia Y, Yu M, Xia L, Wang Y, Yang L, Wang T, Gong W, Tian C*, Liu X*, andWang J*. Rational Design of a Miniature Photocatalytic CO2-Reducing Enzyme.ACS Catal. 2021, 11, 9, 5628-5635. DOI: 10.1021/acscatal.1c00287

22. An X, Chen C, Wang T, Huang A, Zhang D, Han M,Wang J*. Genetic Incorporation of Selenotyrosine Significantly Improves Enzymatic Activity of Agrobacterium radiobacter Phosphotriesterase.ChemBioChem. 2021, 22, 2535- 2539, DOI: 10.1002/cbic.202000460

23. Zheng Z, Guo X, Yu M, Wang X, Lu H, Li F,Wang J*. Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine.ChemBioChem2020 , 21(11):1593 -1596. DOI: 10.1002/cbic.201900735

24. Liu Q, He Q, Lyu X, Yang F, Zhu Z, Xiao P, Yang Z, Zhang F, Yang Z, Wang X, Sun P, Wang Q, Qu C, Gong Z, Lin J, Xu Z, Song S, Huang S, Guo S, Han M, Zhu K, Chen X, Kahsai A., Xiao K, Kong W, Li F, Ruan K, Li Z, Yu X, Niu X, Jin C,Wang J*& Sun J*. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.Nature Communications. 2020, 11, 4857. DOI: https://doi.org/10.1038/s41467-020-18433-5

25. Hu C, Liu X,Wang J*. Electrostatics affect the glow.Science. 2020, 367(6473):26. DOI: 10.1126/science.aba0571.

26. Zheng D, Zhang Y, Liu X,Wang J*. Coupling natural systems with synthetic chemistry for light-driven enzymatic biocatalysis.Photosynth Res. 2020, 143(2):221-231. DOI: 10.1007/s11120-019-00660-7

27. Huang S, Yang F, Cai B, He Q, Liu Q, Qu C, Han M, Kong W, Jia YL, Li F, Yu X, Sun J*,Wang J*. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET.Anal Chem. 2019, 91(23):14936-14942. DOI: 10.1021/acs.analchem.9b03305.

28. Xia L, Han M, Zhou L, Huang A, Yang Z, Wang T, Li F, Yu L, Tian C, Zang Z, Yang QZ, Liu C, Hong W, Lu Y, Alfonta L,Wang J*. S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials.Angew Chem Int Ed Engl. 2019, 58(46):16480-16484.DOI: 10.1002/anie.201909203.

29. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y,Wang J, Fang H, Sun J*, Yu X*. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.J Biol Chem. 2019, 294(21):8653-8663. DOI: 10.1074/jbc.RA118.007129.

30. Yu Y, Liu X,Wang J*. Expansion of Redox Chemistry in Designer Metalloenzymes.Acc Chem Res. 2019,52(3):557-565. DOI: 10.1021/acs.accounts.8b00627.

31. Wang L, Chen X, Guo X, Li J, Liu Q, Kang F, Wang X, Hu C, Liu H, Gong W, Zhuang W, Liu X*,Wang J*. Significant expansion and red-shifting of fluorescent protein chromophore determined through computational design and genetic code expansion.Biophys Rep. 2018, 4(5):273-285. DOI: 10.1007/s41048-018-0073-z.

32. Liu X, Kang F, Hu C, Wang L, Xu Z, Zheng D, Gong W, Lu Y, Ma Y,Wang J*. A genetically encoded photosensitizer protein facilitates the rational design of a miniature photocatalytic CO2-reducing enzyme.Nat Chem. 2018, 10 (12):1201-1206. DOI: 10.1038/s41557-018-0150-4.

33. Mu Z, Zou Z, Yang Y, Wang W, Xu Y, Huang J, Cai R, Liu Y, Mo Y, Wang B, Dang Y, Li Y, Liu Y, Jiang Y, Tan Q, Liu X, Hu C, Li H, Wei S, Lou C, Yu Y,Wang J*. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue.Synth Syst Biotechnol. 2018, 3(3):196-203. DOI: 10.1016/j.synbio.2018.05.001.

34. Dong J, Li F, Gao F, Wei J, Lin Y, Zhang Y, Lou J, Liu G, Dong Y, Liu L, Liu H,Wang J, Gong W*. Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon.J Mol Biol. 2018, 430(21):4183-4194. DOI: 10.1016/j.jmb.2018.08.015.

35. Yang F, Xiao P, Qu CX, Liu Q, Wang L, Liu Z, He Q, Liu C, Xu J, Li R, Li M, Li Q, Guo X, Yang Z, He D, Yi F, Ruan K, Shen Y, Yu X, Sun J*,Wang J*. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.Nat Chem Biol. 2018, 14(9):876-886. DOI: 10.1038/s41589-018-0115-3.

36. Zhang J, Wang L, Zhang J, Zhu J, Pan X, Cui Z,Wang J*, Fang W*, Li Y*. Identifying and Modulating Accidental Fermi Resonance: 2D IR and DFT Study of 4-Azido-l-phenylalanine.J Phys Chem B. 2018, 122(34):8122-8133. DOI: 10.1021/acs.jpcb.8b03887.

37. Li J, Griffith WP, Davis I, Shin I,Wang J, Li F, Wang Y, Wherritt DJ, Liu A*. Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase.Nat Chem Biol. 2018, 14(9):853-860. DOI: 10.1038/s41589-018-0085-5.

38. Zhang F, Zhou Q, Yang G, An L, Li F*,Wang J*. A genetically encoded 19F NMR probe for lysine acetylation.Chem Commun (Camb). 2018, 54(31):3879-3882. DOI: 10.1039/c7cc09825a.

39. Chen L, Naowarojna N, Song H, Wang S,Wang J, Deng Z, Zhao C, Liu P*. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation.J Am Chem Soc. 2018, 140(13):4604-4612. DOI: 10.1021/jacs.7b13628.

40. Yu Y, Hu C, Xia L, andWang J*. Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors.ACS Catal. 2018, 8 (3):1851-1863. DOI: 10.1021/acscatal.7b03754

41. Pan Y, Zhang H, Zheng Y, Zhou J, Yuan J, Yu Y,Wang J*. Resveratrol Exerts Antioxidant Effects by Activating SIRT2 To Deacetylate Prx1.Biochemistry. 2017, 56(48):6325-6328. DOI: 10.1021/acs.biochem.7b00859.

42. Lu J, Zhang H, Chen X, Zou Y, Li J, Wang L, Wu M, Zang J, Yu Y, Zhuang W*, Xia Q*,Wang J*. A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase.Free Radic Biol Med. 2017, 112:287-297. DOI: 10.1016/j.freeradbiomed.2017.07.012.

43. Hu C, Yu Y,Wang J*. Improving artificial metalloenzymes' activity by optimizing electron transfer.Chem Commun (Camb). 2017, 53(30):4173-4186. DOI: 10.1039/c6cc09921a.

44. Yang F, Yu X, Liu C, Qu C, Gong Z, Liu H, Li F, Wang H, He D, Yi F, Song C, Tian C, Xiao K,Wang J*, Sun J*. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and¹⁹F-NMR.Nat Commun. 2015, 6:8202. DOI: 10.1038/ncomms9202.

45. Yu Y, Zhou Q, Wang L, Liu X, Zhang W, Hu M, Dong J, Li J, Lv X, Ouyang H, Li H, Gao F, Gong W, Lu Y*,Wang J*. Significant Improvement of Oxidase Activity through the Genetic Incorporation of a Redox-active Unnatural Amino Acid.Chem Sci. 2015, 6(7): 3881-3885. DOI: 10.1039/C5SC01126D

46. Yu Y, Cui C, Liu X, Petrik ID,Wang J*, Lu Y*. A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme.J Am Chem Soc. 2015, 137(36):11570-11573. DOI: 10.1021/jacs.5b07119.

47. Yu Y, Hu C, Liu X,Wang J*. Synthetic Model of the Oxygen-Evolving Center: Photosystem II under the Spotlight.Chembiochem. 2015, 16(14):1981-1983. doi: 10.1002/cbic.201500302.

48. He T, Gershenson A, Eyles SJ, Lee YJ, Liu WR,Wang J, Gao J, Ro, Roberts MF*. Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion.J Biol Chem. 2015, 290(31):19334-19342. DOI: 10.1074/jbc.M115.668343.

49. Lv X, Yu Y, Zhou M, Hu C, Gao F, Li J, Liu X, Deng K, Zheng P, Gong W, Xia A*,Wang J*. Ultrafast photoinduced electron transfer in green fluorescent protein bearing a genetically encoded electron acceptor.J Am Chem Soc. 2015, 137(23):7270-7273. DOI: 10.1021/jacs.5b03652.

50. Wang T, Zhou Q*, Li F, Yu Y, Yin X*,Wang J*. Genetic Incorporation of N(ε)-Formyllysine, a New Histone Post-translational Modification.Chembiochem. 2015, 16(10):1440-1442. DOI: 10.1002/cbic.201500170.

51. Zheng Y, Yu F, Wu Y, Si L, Xu H, Zhang C, Xia Q, Xiao S, Wang Q, He Q, Chen P,Wang J, Taira K, Zhang L, Zhou D*. Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion.Nucleic Acids Res. 2015, 43(11): e73. DOI: 10.1093/nar/gkv202.

52. Li F, Dong J, Hu X, Gong W, Li J, Shen J, Tian H,Wang J*. A covalent approach for site-specific RNA labeling in Mammalian cells.Angew Chem Int Ed Engl. 2015, 54(15):4597-4602. DOI: 10.1002/anie.201410433.

53. Yu Y, Lv X, Li J, Zhou Q, Cui C, Hosseinzadeh P, Mukherjee A, Nilges MJ,Wang J*, Lu Y*. Defining the role of tyrosine and rational tuning of oxidase activity by genetic incorporation of unnatural tyrosine analogs.J Am Chem Soc. 2015 Apr 15;137(14):4594-4597. DOI: 10.1021/ja5109936.

54. Liu X, Jiang L, Li J, Wang L, Yu Y, Zhou Q, Lv X, Gong W, Lu Y,Wang J*. Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers.J Am Chem Soc. 2014, 136(38):13094-13097. DOI: 10.1021/ja505219r.

55. Pan Y, Jin JH, Yu Y*,Wang J*. Significant enhancement of hPrx1 chaperone activity through lysine acetylation.Chembiochem. 2014, 15(12):1773-1776. DOI: 10.1002/cbic.201402164.

56. Hu C, Chan SI, Sawyer EB, Yu Y,Wang J*. Metalloprotein design using genetic code expansion.Chem Soc Rev. 2014, 43(18):6498-6510. DOI: 10.1039/c4cs00018h.

57. Wu F, Zhang H, Zhou Q, Wu M, Ballard Z, Tian Y,Wang J*, Niu Z*, and Huang Y. Expanding the genetic code for site-specific labelling of tobacco mosaic virus coat protein and building biotin-functionalized virus-like particles.Chem. Commun. 2014, 50, 4007-4009. DOI: 10.1039/c3cc49137d .

58. Bi K, Zheng Y, Gao F, Dong J,Wang J, Wang Y*, Gong W*. Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition.Protein Cell. 2014, 5(2):151-159. DOI: 10.1007/s13238-013-0012-1.

59. Lin Y*,Wang J*& Lu Y*. Functional tuning and expanding of myoglobin by rational protein design.Science China Chemistry. 2014, 57(3): 346-355. DOI: 10.1007/s11426-014-5063-5

60. Zheng Y, Lv X,Wang J*. A genetically encoded sulfotyrosine for VHR function research.Protein Cell. 2013, 4(10):731-734. DOI: 10.1007/s13238-013-3907-y.

61. Lin Y,Wang J*. Structure and function of heme proteins in non-native states: a mini-review.J Inorg Biochem. 2013, 129:162-171. DOI: 10.1016/j.jinorgbio.2013.07.023.

62. Pan C, Liu H, Gong Z, Yu X, Hou X, Xie D, Zhu X, Li H, Tang J, Xu Y, Yu J, Zhang L, Fang H, Xiao K, Chen Y,Wang J, Pang Q, Chen W*, Sun J*. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.Sci Rep. 2013, 3: 2333. DOI: 10.1038/srep02333.

63. Li F, Zhang H, Sun Y, Pan Y, Zhou J,Wang J*. Expanding the genetic code for photoclick chemistry in E. coli, mammalian cells, and A. thaliana.Angew Chem Int Ed Engl. 2013, 52(37):9700-9704. DOI: 10.1002/anie.201303477.

64. Lin Y, Sawyer E*,Wang J*. Rational heme protein design: all roads lead to Rome.Chem Asian J. 2013, 8(11):2534-2544. DOI: 10.1002/asia.201300291.

65. Liu X, Li J, Hu C, Zhou Q, Zhang W, Hu M, Zhou J,Wang J*. Significant expansion of the fluorescent protein chromophore through the genetic incorporation of a metal-chelating unnatural amino acid.Angew Chem Int Ed Engl. 2013, 52(18):4805-4809. DOI: 10.1002/anie.201301307.

66. Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun J, Gong W*, Tian C,Wang J*. A genetically encoded 19F NMR probe for tyrosine phosphorylation.Angew Chem Int Ed Engl. 2013, 52(14):3958-3962. DOI: 10.1002/anie.201300463.

67. Xu X, Hu X*,Wang J*. A new synthetic protocol for coumarin amino acid.Beilstein J Org Chem. 2013, 9:254-259. DOI: 10.3762/bjoc.9.30.

68. Zhou Q, Hu M, Zhang W, Jiang L, Perrett S, Zhou J,Wang J*. Probing the function of the Tyr-Cys cross-link in metalloenzymes by the genetic incorporation of 3-methylthiotyrosine.Angew Chem Int Ed Engl. 2013, 52(4):1203-1207. DOI: 10.1002/anie.201207229.

69. Yu Z, Pan Y, Wang Z,Wang J*, Lin Q*. Genetically encoded cyclopropene directs rapid, photoclick-chemistry-mediated protein labeling in mammalian cells.Angew Chem Int Ed Engl. 2012, 51(42):10600-10604. DOI: 10.1002/anie.201205352.

70. Liu X, Li J, Dong J, Hu C, Gong W*,Wang J*. Genetic incorporation of a metal-chelating amino acid as a probe for protein electron transfer.Angew Chem Int Ed Engl. 2012, 51(41):10261-10265. DOI: 10.1002/anie.201204962.

71. Hua T, Wu D, Ding W,Wang J, Shaw N*, Liu Z*. Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal β-oxidation of unsaturated fatty acids.J Biol Chem. 2012, 287(34):28956-28965. DOI: 10.1074/jbc.M112.385351.

72. Liu X, Yu Y, Hu C, Zhang W, Lu Y*,Wang J*. Significant increase of oxidase activity through the genetic incorporation of a tyrosine-histidine cross-link in a myoglobin model of heme-copper oxidase.Angew Chem Int Ed Engl. 2012, 51(18):4312-4316. DOI: 10.1002/anie.201108756.

73. Charbon G,Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E*. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid.Bioorg Med Chem Lett. 2011, 21(20):6067-6070. DOI: 10.1016/j.bmcl.2011.08.057.

74. Charbon G, Brustad E, Scott KA,Wang J, Lobner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E*. Subcellular protein localization by using a genetically encoded fluorescent amino acid.Chembiochem. 2011, 12(12):1818-1821. DOI: 10.1002/cbic.201100282.

75.Wang J*, Zhang W, Song W, Wang Y, Yu Z, Li J, Wu M, Wang L, Zang J, Lin Q*. A biosynthetic route to photoclick chemistry on proteins.J Am Chem Soc. 2010, 132 (42): 14812 -14818. DOI: 10.1021/ja104350y.

76. Mills JH, Lee HS, Liu CC,Wang J, Schultz PG.*. A genetically encoded direct sensor of antibody-antigen interactions.Chembiochem. 2009, 10(13):2162-2164. DOI: 10.1002/cbic.200900254.

77. Peters FB, Brock A,Wang J, Schultz PG*. Photocleavage of the polypeptide backbone by 2-nitrophenylalanine.Chem Biol. 2009, 16(2):148-152. DOI: 10.1016/j.chembiol.2009.01.013.

78. Guo J,Wang J, Lee JS, Schultz PG.*. Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.Angew Chem Int Ed Engl. 2008, 47(34):6399-6401. DOI: 10.1002/anie.200802336.

79. Guo J,Wang J, Anderson JC, Schultz PG*. Addition of an alpha-hydroxy acid to the genetic code of bacteria.Angew Chem Int Ed Engl. 2008, 47(4):722-725. DOI: 10.1002/anie.200704074

80.Wang J, Rosenblatt MM, Suslick KS*. NMR structures of peptide--RuII(porphyrin) complexes.J Am Chem Soc. 2007, 129(46):14124-14125. DOI: 10.1021/ja075532v

81.Wang J, Schiller SM, Schultz PG*. A biosynthetic route to dehydroalanine-containing proteins.Angew Chem Int Ed Engl. 2007, 46(36):6849-51. DOI: 10.1002/anie.200702305

82.Wang J, Xie J, Schultz PG*. A genetically encoded fluorescent amino acid.J Am Chem Soc. 2006, 128(27):8738-8739. DOI: 10.1021/ja062666k

83. Rosenblatt MM,Wang J, Suslick KS*. De novo designed cyclic-peptide heme complexes.Proc Natl Acad Sci U S A. 2003, 100(23):13140-13145. DOI: 10.1073/pnas.2231273100

84.Wang J, Luthey-Schulten ZA, Suslick KS*. Is the olfactory receptor a metalloprotein?Proc Natl Acad Sci U S A. 2003, 100(6):3035-3039. DOI: 10.1073/pnas.262792899

(From Jiangyun Wang, August 20, 2024)