1964 Graduated from Department of Biophysics, University of Science and Technology of China (USTC)

1978 - 1980 Postgraduate: Institute of Theoretical Chemistry, Jilin University

1985.6 - 1987.8 Institute for Theoretical Chemistry, University Erlangen-Nurnberg, FRG, as a Fellow of Alexander von Humboldt Foundation

1994 - 2003 Dept. of Statistics, the Chinese University of Hong Kong; Interdivisional Program in Statistics, the University of California at Los Angeles (UCLA); Department of Biostatistics, Harvard University; Institute of Protein Research, Osaka University, Japan; National Center for Theoretical Sciences, Taiwan; as a Visiting Scholar or Visiting Professor

1989 - Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences

2007 Elected as an Academician of the Chinese Academy of Sciences

2014 Elected as an Academician of theInternationaI Academy of Sciences for Europe and Asia

Currently, Prof. Chen serves as a member of Human Genome Organization (HUGO), a member of the biomacromolecule group of The Committee on Data for Science and Technology (CODATA), and a member of the bioinformatics professional committee of the International Union of Pure and Applied Physics (IUPAP). In addition, Prof. Chen is the General-secretary and Vice president of Chinese Society of Biophysics.

Professor Runsheng Chen is one of the pioneer scholars developing the researches on theoretical biology, bioinformatics and noncoding RNA in China. For more than thirty years, Prof. Chen has led his group to perform a series of systemic researches in the field of bioinformatics, including the whole genome assembly and annotation for T. tengcongensis B4 (the first bacterium genome completely sequenced in China), the 1% Human Genome Project, and the Draft Sequence of the Rice Genome. Since 2001, Prof. Chen has rapidly expanded his interest to the investigation of noncoding RNAs, two widely used noncoding RNA databases (NONCODE,http://www.noncode.org/and NPInter,http://www.bioinfo.org/NPInter/) have been established and updated periodically. So far, Prof. Chen has published more than 300 papers in SCI, and made more than 20 conference or group reports in the international academic conferences since 1996. For his outstanding early studies on genomic informatics, Prof. Chen was invited to give the "Kotani Memorial Lecture" on the 15th International CODATA Conference, Tsukuba, Japan, 29 Sep. - Oct. 1996, and then selected as the winner of "Kotani Prize". Recently, Prof. Chen was granted the Prize for Scientific and Technological Progress of Ho Leung Ho Lee Foundation in 2008, Tan Jiazhen life sciences and Achievement Award in 2012, and second-class prize of national science and Technology Progress Award in 2013.

[60] Chen S, Wang H, Zhang D,Chen R, Luo J. Readon: a novel algorithm to identify read-through transcripts with long-read sequencing data.Bioinformatics2024; 40(6).

[59] Liu L, Liu Z, Liu Q, Wu W, Lin P, . . . Luo J, Rich JN, Xie Q, Jiang T,Chen R. LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation.Nat Commun2023; 14(1): 7526.

[58] Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL,Chen R, . . . Rinn JL, Spector DL, Ulitsky I, Wan Y, Wilusz JE, Wu M. Long non-coding RNAs: definitions, functions, challenges and recommendations.Nat Rev Mol Cell Biol2023; 24(6): 430-447.

[57] Yue H, Li A, Tang Y,Chen R. TapHi-C for profiling genome-wide chromosome conformation capture.Trends Plant Sci2023; 28(10): 1192-3.

[56] Yang Z, Zeng X, Zhao Y,Chen R. AlphaFold2 and its applications in the fields of biology and medicine.Signal Transduct Target Ther2023; 8(1): 115.

[55] Zheng Y, Luo H, Teng X, . . . Zhao Y,Chen R, He S. NPInter v5.0: ncRNA interaction database in a new era.Nucleic Acids Res2023; 51(D1): D232-D9.

[54] Zhang L, Badai J, Wang G, Ru X, . . . Feng H,Chen R, Zhao Y, Chen Y. Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis.Frontiers in immunology2023; 14: 1123652.

[53] Zhang C, Wang D, Hao Y, Wu S, Luo J, . . . Fu XD, Yang X,Chen R, Teng Y. LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly.Mol Cell2022; 82(21): 4018-32 e9.

[52] Zhang Y, Qiao X, Liu L, . . . He S,Chen R, Chen C. Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8.Redox Biol2022; 54: 102383.

[51] Yang B, Zhang Y, Sun L, . . .Chen R, Luo J, Wang T, Jiang J, Qin Y. Modulated ultrasmall γ-Fe2O3 nanocrystal assembles for switchable magnetic resonance imaging and photothermal-ferroptotic-chemical synergistic cancer therapy.Advanced Functional Materials2022.

[50] Wang J, Shi Y, Zhou H, Zhang P, . . . Zhao Y, Zeng X, He S,Chen R. piRBase: integrating piRNA annotation in all aspects.Nucleic Acids Res2022; 50(D1): D265-D72.

[49] Cui X, Zhang R, Yang Y, Wu E, . . . Sun J, Luo J, Zhang S,Chen R, Xi JJ. Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory.Cell Rep2022; 38(8): 110398.

[48] Zhao L, Wang J, Li Y, Song T, . . .Chen R, Zhao Y, He S. NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants.Nucleic Acids Res2021; 49(D1): D165-D171.

[47] Zhang Q, Wu E, Tang Y, Cai T, . . . Luo J,Chen R, Yang F. Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs.Mol Cell Proteomics2021; 20: 100109.

[46] Xue H, Niu Y, Segraves K, Nie R, Hao Y, Zhang L, . . .Chen R, Yang X. The draft genome of the specialist flea beetle Altica viridicyanea (Coleoptera: Chrysomelidae).BMC Genomics2021; 22(1): 243.

[45] Wu E, Guo X, Teng X, Zhang R, . . . Luo J, Wang J,Chen R. Discovery of Plasma Membrane-Associated RNAs through APEX-seq.Cell Biochem Biophys2021; 79(4): 905-917.

[44] Li Y, Zhou H, Chen X, Zheng Y, . . . Luo H, Hao Y,Chen R, Zhang P, He S. SmProt: A Reliable Repository with Comprehensive Annotation of Small Proteins Identified from Ribosome Profiling.Genomics Proteomics Bioinformatics2021; 19(4): 602-610.

[43] Lai C, Liu L, Liu Q, Wang K, Cheng S, . . . Luo J, Wang X,Chen R, Yang P. Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a.Cell Death Differ2021; 28(10): 2900-2915.

[42] Wang D, Zhou Z, Wu E, Ouyang C, Wei G, . . . Reed SH, Luo J,Chen R. LRIK interacts with the Ku70-Ku80 heterodimer enhancing the efficiency of NHEJ repair.Cell Death Differ2020; 27(12): 3337-3353.

[41] Fan Z, Chen X, Liu L, Zhu C, Xu J, . . . Cui Y, Zhang X,Chen R. Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.Arthritis Rheumatol2020; 72(6): 985-996.

[40] Hao Y, Wang D, Wu S, Li X, . . . Fu XD,Chen R, He S. Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division.Genome Res2020; 30(11): 1570-1582.

[39] Wu S, Wu E, Wang D, Niu Y, Yue H, Zhang D, Luo J,Chen R. LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial-mesenchymal-transition in gastric cancer.Cancer Genet2020; 241: 25-33.

[38] Teng X, Chen X, Xue H, Tang Y, Zhang P, Kang Q, Hao Y,Chen R, Zhao Y, He S. NPInter v4.0: an integrated database of ncRNA interactions.Nucleic Acids Res2020; 48(D1): D160-D165.

[37] Fan Z,Chen R, Chen X. SpatialDB: a database for spatially resolved transcriptomes.Nucleic Acids Res2020; 48(D1): D233-D237.

[36] Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, . . .Chen R, Tian Y, Fan Z. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.EMBO J2019: e101110.

[35] Chen X, Hao Y, Cui Y, Fan Z,Chen R. LncVar: Deciphering Genetic Variations Associated with Long Noncoding Genes.Methods Mol Biol2019; 1870: 189-198.

[34] Wang J, Zhang P, Lu Y, Li Y, Zheng Y, Kan Y,Chen R, He S. piRBase: a comprehensive database of piRNA sequences.Nucleic Acids Res2019; 47(D1): D175-D180.

[33] Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, . . .Chen R, Tian Y, Fan Z. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.EMBO J2018; 37(8).

[32] Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, . . .Chen R, Tian Y, Fan Z. Long noncoding RNA LncHand2 promotes liver repopulation via c-Met signaling.J Hepatol2018; 69(4): 861-872.

[31] Fang S, Zhang L, Guo J, Niu Y, Wu Y, Li H, . . .Chen R, Zhao Y. NONCODEV5: a comprehensive annotation database for long non-coding RNAs.Nucleic Acids Res2018; 46(D1): D308-D314.

[30] Hao Y, Zhang L, Niu Y, Cai T, Luo J, He S, . . .Chen R. SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci.Brief Bioinform2018; 19(4): 636-643.

[29] Cui Y, Chen X, Niu Y, Wang D, Luo H, Fan Z, . . .Chen R. Dynamic-BM: multispecies Dynamic BodyMap database from temporal RNA-seq data.Brief Bioinform2018; 19(6): 1302-1309.

[28] Yan X, Zhang D, Wu W, Wu S, Qian J, Hao Y, . . .Chen R, Fan Z. Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a.Cancer Res2017; 77(23): 6704-6716.

[27] Wang Z, Hao Y, Zhang C, Wang Z, Liu X, Li G, . . .Chen R, Jiang T. The Landscape of Viral Expression Reveals Clinically Relevant Viruses with Potential Capability of Promoting Malignancy in Lower-Grade Glioma.Clin Cancer Res2017; 23(9): 2177-2185.

[26] Sun Y, Wei G, Luo H, Wu W, Skogerbo G, Luo J,Chen R. The long noncoding RNA SNHG1 promotes tumor growth through regulating transcription of both local and distal genes.Oncogene2017; 36(49): 6774-6783.

[25] Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, . . .Chen R, Tian Y, Fan Z. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.Nat Immunol2017; 18(5): 499-508.

[24] Chen X, Hao Y, Cui Y, Fan Z, He S, Luo J andChen R. LncVar: a database of genetic variation associated with long non-coding genes.Bioinformatics2017; 33: 112-118.

[23] Zhao Y, Li H, Fang S, Kang Y, Wu W, Hao Y, . . .Chen R. NONCODE 2016: an informative and valuable data source of long non-coding RNAs.Nucleic Acids Res2016; 44: D203-208.

[22] Liu L, Yue H, Liu Q, Yuan J, Li J, Wei G, . . .Chen R. LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.Oncotarget2016; 7: 15787-15800.

[21] Cui Y, Chen X, Luo H, Fan Z, Luo J, He S, . . .Chen R. BioCircos.js: an interactive Circos JavaScript library for biological data visualization on web applications.Bioinformatics2016; 32: 1740-1742.

[20] Xiao T, Liu L, Li H, Sun Y, Luo H, Li T, . . .Chen R. Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPalpha.Stem Cell Reports2015; 5: 856-865.

[19] Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, . . .Chen R, Fan Z. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling.Cell Stem Cell2015; 16: 413-425.

[18] Yuan J, Wu W, Xie C, Zhao G, Zhao Y andChen R. NPInter v2.0: an updated database of ncRNA interactions.Nucleic Acids Res2014; 42: D104-108.

[17] Li J, Chen Z, Tian L, Zhou C, He MY, Gao Y, . . .Chen R, He J. LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma.Gut2014; 63: 1700-1710.

[16] Lu X, Wang L, Chen S, He L, Yang X, Shi Y, . . .Chen R, . . . Coronary ADG-WR. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.Nature Genetics2012; 44: 890-4.

[15] Wang Y, Chen J, Wei G, He H, Zhu X, Xiao T, . . .Chen R. The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression.Nucleic Acids Res2011; 39: 5203-5214.

[14] Zhao Y, He S, Liu C, Ru S, Zha H, Yang Z, . . .Chen R. MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control.Trends in Genetics2008; 24: 323-327.

[13] He S, Su H, Liu C, Skogerbo G, He H, He D, . . .Chen R. MicroRNA-encoding long non-coding RNAs.BMC Genomics2008; 9: 236

[12] Aftab MN, He H, Skogerbo G andChen R. Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins.BMC Genomics2008; 9: 278.

[11] He H, Wang J, Liu T, Liu XS, Li T, Wang Y, . . .Chen R. Mapping the C-elegans noncoding transcriptome with a whole-genome tiling microarray.Genome Res2007; 17: 1471-1477.

[10] Zhang Z, Liu C, Skogerbo G, Zhu X, Lu H, Chen L, . . .Chen R. Dynamic changes in subgraph preference profiles of crucial transcription factors.Plos Computational Biology2006; 2: 383-391.

[9] Zhang Y, Li S, Skogerbo G, Zhang Z, Zhu X, Zhang Z, . . .Chen R. Phylophenetic properties of metabolic pathway topologies as revealed by global analysis.BMC Bioinformatics2006; 7:

[8] Muzny D, Scherer S, Kaul R, Wang J, Yu J, Sudbrak R, . . .Chen R, . . .Gibbs R. The DNA sequence, annotation and analysis of human chromosome 3.Nature2006; 440: 1194-1198.

[7] He H, Cai L, Skogerbo G, Deng W, Liu T, Zhu X, . . .Chen R. Profiling Caenorhabditis elegans non-coding RNA expression with a combined microarray.Nucleic Acids Res2006; 34: 2976-2983.

[6] Deng W, Zhu X, Skogerbo G, Zhao Y, Fu Z, Wang Y, . . .Chen R. Organization of the Caenorhabditis elegans small non-coding transcriptome: Genomic features, biogenesis, and expression.Genome Res2006; 16: 20-29.

[5] Liu C, Bai B, Skogerbo G, Cai L, Deng W, Zhang Y, . . .Chen R. NONCODE: an integrated knowledge database of non-coding RNAs.Nucleic Acids Res2005; 33: D112-D115.

[4] Yu J, Hu S, Wang J, Wong G, Li S, Liu B, . . .Chen R, . . . Yang H. A draft sequence of the rice genome (Oryza sativa L. ssp indica).Science2002; 296: 79-92.

[3] Bu D, Zhao Y, Cai L, Xue H, Zhu X, Lu H, . . .Chen R. Topological structure analysis of the protein-protein interaction network in budding yeast.Nucleic Acids Res2003; 31: 2443-2450.

[2] Bao Q, Tian Y, Li W, Xu Z, Xuan Z, Hu S, . . .Chen R, . . . Yang H. A complete sequence of the T tengcongensis genome.Genome Res2002; 12: 689-700.

[1] Li W, Fang W, Ling L, Wang J, Xuan Z andChen R. Phylogeny Based on Whole Genome as inferred from Complete Information Set Analysis.Journal of Biological Physics2002; 28: 439-447.

（From Runsheng Chen, July 30, 2024）