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脑与认知科学国家重点实验室

杨艳博士研究员博士生导师

中科院生物物理所，脑与认知科学国家重点实验室，研究组长

研究方向：运动学习和运动控制的神经机制

电子邮件：yyang@ibp.ac.cn

电话：010-64886521

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmX_Y/202005/t20200519_341367.html

简历：

　　1998 - 2002 云南大学理学院物理系，理学学士

　　2002 - 2007 中国科学院生物物理研究所，理学博士

　　2007 - 2012 美国加州大学旧金山分校，博士后

　　2012 - 2016 美国杜克大学医学院，助理研究员

　　2016 - 至今中国科学院生物物理研究所，研究员，博士生导师

　　2018 入选国家自然基金委“优青项目”

获奖及荣誉：

社会任职：

研究方向：

　　人和动物最明显的生理特征是运动，走、爬、飞、游。要保证个体生存和种族繁衍必须精确地控制行为动作。而行为动作的精确性离不开后天学习。个人的运动学习和执行能力会受到多种因素影响，包括对感觉信息的认知、年龄、健康程度、运动经验及其运动相关的记忆。因此，研究运动控制的神经机制是揭示复杂脑的窗口。

　　我们所感知的外界信息中，80%左右是通过眼睛获得的。眼球运动被认为是研究感觉-运动界面的极好模型。课题组结合认知行为检测、电生理技术、脑功能调控技术、功能成像技术及神经计算仿真研究脑精确控制行为动作的神经机制。同时也将探索其在脑疾病的防治、诊断，以及智能技术，例如仿人机器人中应用的可能。

承担项目情况：

代表论著：

1. Tong Xiao; Kaijie Wu; Peiliang Wang; Yali Ding; Xiao Yang; Chao Chang*;Yan Yang*. (2023). Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons,eLife, 78729.https://doi.org/10.7554/eLife.78729. (* Corresponding authors).

2. Lasse Knudsen; Christopher J. Bailey; Jakob U. Blicher;Yan Yang; Peng Zhang; Torben E. Lund. (2023). Improved sensitivity and microvascular weighting of 3T laminar fMRI with GE-BOLD using NORDIC and phase regression,NeuroImage,https://doi.org/10.1016/j.neuroimage.2023.120011.

3. Huang Wang, Xiaoxiao Wang, Yanming Wang, Du Zhang,Yan Yang, Yifeng Zhou, Bensheng Qiu, Peng Zhang. (2023). White matter BOLD signals at 7 Tesla reveal visual field maps in optic radiation and vertical occipital fasciculus.NeuroImage, 269, 119916.https://doi.org/10.1016/j.neuroimage.2023.119916.

4. Huixi Dou, Huan Wang, Sainan Liu, Jun Huang, Zuxiang, Liu, Tiangang Zhou,Yan Yang*. (2023). Form properties of moving targets bias smooth pursuit target selection in monkeys.Neuroscience Bulletin,https://doi.org/10.1007/s12264-023-01022-z. (* Corresponding author).

5. Xiaohui Wang, Xiaoli Cui, Yang Li, Fei Li, Yue Li, Jinye Dai, Han Hu, Xuefeng Wang, Jianyuan Sun,Yan Yang*, Shuli Zhang. (2022). MC4R deficiency causes postsynaptic transmission dysregulation as a crucial culprit for obesity.Diabetes,https://doi.org/10.2337/db22-0162.

6. Xiaoli Cui, Ruijin Zhang, Ye Yang, Erzhong Wu, Yiheng Tang, Zhihua Zhao, Chao Li, Lei Yang, Xueyi Teng, Yanzhen Ye, Ya Cui, Feng Xu, Zewen Su, Dongpeng Wang, Dongdong Zhang,Yan Yang, Jianyuan Sun, Jianjun Luo, Shuli Zhang, Runsheng Chen, and Jianzhong Jeff Xi. (2022). Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory.Cell Reports, 38, Feb. 22,https://doi.org/10.1016/j.celrep.2022.110398.

7. Nathan J. Hall,Yan Yang, and Stephen G. Lisberger, (2018) Multiple components in direction learning in smooth pursuit eye movements of monkeys.Journal of Neurophysiology, 120(4):2020-2035. doi: 10.1152/jn.00261.2018.

8.Yan Yang, Qian Wang, Shu-rong Wang, Yi Wang and Qian Xiao, (2017) Representation of time interval entrained by periodic stimuli in the visual thalamus of pigeons.eLife; 6:e27995. doi:https://doi.org/10.7554/eLife.27995.

9.Yan Yang*, Stephen G. Lisberger, (2017) Modulation of complex-spike duration and probability during cerebellar motor learning in visually guided smooth-pursuit eye movements of monkeys.eNeuro, 10;4(3). doi: 10.1523/ENEURO.0115-17.2017. (*Corresponding author).

10. Jun Huang,Yan Yang, Ke Zhou, Xudong Zhao, Quan Zhou, Hong Zhu, Yingshan Yang, Chunming Zhang, Yifeng Zhou and Wu Zhou. (2017) Rapid processing of a global feature in the ON visual pathways of behaving monkeys.Frontiers in Neuroscience,perception science, 25;11:474. doi: 10.3389/fnins.2017.00474.

11.Yan Yang*,Stephen G Lisberger*, (2014) Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration.Nature, 510(7506):529-32.(* Corresponding authors).

12.Yan Yang*,Stephen G Lisberger, (2014) Role of plasticity at different sites across the time course of cerebellar motor learning.Journal of Neuroscience,34(21):7077-90.(* Corresponding author).

13.Yan Yang, Stephen G Lisberger, (2013) Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning.eLife, 2(0): e01574.

14.Yan Yang, Stephen G Lisberger, (2010) Learning on multiple timescales in smooth pursuit eye movements.Journal of Neurophysiology, 104(5):2850-62.

15.Yan Yang, Peng Cao, Yang Yang, Shu-Rong Wang, (2008) Corollary discharge circuits for saccadic modulation of the pigeon visual system.Nature Neuroscience, 11(5):595-602.

( Evaluated by Faculty of 1000 ).

16. Yang Yang,Yan Yang, Shu-Rong Wang, (2008) Neuronal circuitry and discharge patterns controlling eye movements in the pigeon.Journal of Neuroscience, 15; 28(42):10772-80.

（资料来源：杨艳研究员，2023-03-17）