中文 Prof. Yan Qin GroupResearch

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A complete list of publications can be foundHERE

Zhang D, Kaige Y, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Lou Z, Gao N* andQin Y*(2016) (*corresponding author) EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome,Nat Struct Mol Biol.
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Zhang Y, Mandava CS, Cao W, Li X, Zhang D, Li N, Zhang Y, Zhang X,Qin Y, Mi K, Lei J*, Sanyal S*, Gao N* (2015) (*corresponding author) HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions,Nat Struct Mol Biol.22, 906–913.
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Zhang D, Kaige Y, Zhang Y, Liu G, Cao X, Song G, Xie Q*, Gao N*,Qin Y*(2015) (*corresponding author) New insights into the enzymatic role of EF-G in ribosome recycling,Nucleic Acids Res.1674–1683.
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Liu G, Zhang D, Song G, Li Z, Zhang D, Lyv Z, Aachenbach J, Dong J, Gong W, Zhao X, Nierhaus K H andQin Y*(2014) (*corresponding author) EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex,Nat Struct Mol Biol.21, 817–824.
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Yang F, Gao Y, Li ZK, Chen LM, Xia Z, Xu T*,Qin Y*(2014) (*corresponding author) Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans.Biochim Biophys Acta.1674–1683.
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Yamamoto H#,Qin Y#, Achenhach J#, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (#co-first author) EF-G and EF4: Translocation and back-translocation on the bacterial ribosome.Nat Rev Microbiol.12 (2) 89-100 (Invited review).
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Zhang D andQin Y*(2013) (*corresponding author) The Paradox of Elongation Factor 4: highly conserved yet of no physiological significance?Biochem J.452 (2), 173-181 (invited review).
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Zhang D, Liu G, Xue J, Lou J, Nierhaus K H, Gong W* andQin Y*(2012) (*corresponding author) Common chaperone activity in the G-domain of trGTPase protects L11–L12 interaction on the ribosome,Nucleic Acids Res.40 (21) 10851-10865.
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Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W andQin Y*(2012) (*corresponding author) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases,Nat Struct Mol Biol.19(4)403-410.
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Di Giacco V#, Marquez V#,Qin Y#, Pech M, Triana-Alonso FJ, Wilson DN, Nierhaus KH (2008) (#co-first author). Shine-dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the aug.Proc Natl Acad Sci U S A.105(31):10715-10720.
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Connell SR#, Topf M#,Qin Y#, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM (2008) (#co-first author) A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.Nat Struct Mol Biol.15(9):910-915.
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Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH* (2006) (*corresponding author) The highly conserved lepa is a ribosomal elongation factor that back-translocates the ribosome.Cell.127(4):721-733.
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