邓红雨----中国科学院生物物理研究所

邓红雨　/　博士研究员博士生导师

国家“杰出青年科学基金”获得者 中国科学院生物物理研究所，生物大分子重点实验室，研究组长

研究方向：病毒复制和组装释放的分子机理；病毒与天然免疫系统的互作；新型疫苗的研发

电子邮件： hydeng@ibp.ac.cn

电　　话： 010-64888407

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页： http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmA_G/202005/t20200519_341421.html

基本情况研究方向代表成果人才培养团队风采

简历

1987 - 1991 浙江大学，生物科学与技术系，理学士

1992 - 1997 美国罗彻斯特大学，博士

1998 - 2002 爱因斯坦医学院及加州大学洛杉矶分校，博士后

2002 - 2004 加州大学洛杉矶分校，助理研究员及助理教授

2004.11 - 至今　中国科学院生物物理研究所，研究员

获奖及荣誉

社会任职

2019.12 - 至今中国研究型医院学会病毒肿瘤学专业委员会，副主任委员

2021.05 - 至今中国生物物理学会，第十二届理事会理事

2017.01 - 2021.01 Virologica Sinica，英文编委

2023.01 - 2027.12 Science Bulletin，英文编委

承担项目情况

　　邓红雨研究组长期的研究方向是病毒复制及组装释放的分子机理、病毒与宿主天然免疫系统之间的相互作用以及新型疫苗的研发。目前的主要研究对象为囊膜病毒，包括疱疹病毒和冠状病毒。截至目前已在Science Advances，Molecular Cell，PNAS，Journal of Virology，Nature Communications,Journal of Cell Biology等国际著名期刊发表论文60余篇。

　　研究表明约15-20%的人类癌症在病因学上与病毒感染有关。邓红雨研究组长期的研究重点是疱疹病毒γ亚家族的成员，包括Epstein-Barr病毒（EBV）和Kaposi's肉瘤相关疱疹病毒（KSHV），这两种病毒与肿瘤的发生发展密切相关，可引起鼻咽癌和恶性淋巴瘤等。以往的研究大都关注于病毒潜伏期表达的致瘤基因，而近期临床和基础研究结果都表明，裂解期复制对病毒致瘤亦至关重要。由于EBV和KSHV难以在体外进行高滴度培养并且缺乏理想的小动物模型，对其裂解期复制的研究受到了限制。邓红雨研究组同时采用了在分子水平上与EBV以及KSHV高度同源的鼠疱疹病毒68（MHV-68）为实验模型，研究致瘤疱疹病毒的组装释放以及病毒与宿主相互作用的机理。通过长期积累，已建立了一套较完整的体系，在分子、细胞和动物水平上深入系统地研究致瘤性疱疹病毒复制的关键步骤、调控机理及与宿主的相互作用。

　　新冠疫情爆发后，邓红雨研究组快速开展了针对冠状病毒的研究。利用在疱疹病毒研究过程中建立的针对囊膜病毒组装释放的实验体系以及病毒与宿主细胞相互作用的研究方法和经验，研究冠状病毒复制及组装释放的分子机理；同时以同属于β冠状病毒的人类冠状病毒HCoV-OC43及鼠肝炎病毒MHV-A59为模型，研究冠状病毒与宿主细胞之间的相互作用机理，为抗病毒药物的研发与设计提供新靶点和新思路。

　　目前主要研究方向如下：

　　1. 囊膜病毒复制和组装释放的分子机理

　　2. 病毒与天然免疫系统间的相互作用

　　3. 新型疫苗的研发

代表论著(*：通讯作者)

1. Tian H, Yu K, He L, Xu H, Han C, Zhang X, Wang X, Zhang X, Zhang L, Gao G,Deng H*. RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator.Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2218825120. doi: 10.1073/pnas.2218825120.

2. Ji M^#, Li M^#, Sun L^#,Deng H*, Zhao YG*. DMV biogenesis during β-coronavirus infection requires autophagy proteins VMP1 and TMEM41B.Autophagy. 2023 Feb;19(2):737-738. doi: 10.1080/15548627.2022.2103783.

3. Zhou S, Fu Z, Zhang Z, Jia X, Xu G, Sun L, Sun F, Gao P, Xu P,Deng H*. Liquid-liquid phase separation mediates the formation of herpesvirus assembly compartments.J Cell Biol. 2023 Jan 2;222(1):e202201088. doi: 10.1083/jcb.202201088. Epub 2022 Oct 17.

4. Jia X^#, Sun L^#, Shen S, Zhang Z, Lyu Y, Guo H,Deng H*. The Interaction between Tegument Proteins ORF33 and ORF45 Plays an Essential Role in Cytoplasmic Virion Maturation of a Gammaherpesvirus.J Virol. 2022 Nov 23;96(22):e0107322. doi: 10.1128/jvi.01073-22. Epub 2022 Oct 27.

5. Gao X^#, Tian H^#, Zhu K^#, Li Q, Hao W, Wang L, Qin B,Deng H*, Cui, S*. Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport.Nat Commun. 2022 Aug 15;13(1):4782. doi: 10.1038/s41467-022-32489-5.

6. Ji M^#, Li M^#, Sun L^#, Zhao H, Li Y, Zhou L, Yang Z, Zhao X, Qu W, Xue H, Zheng Z, Li Y,Deng H*, Zhao YG*. VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection.J Cell Biol. 2022 Jun 6;221(6):e202112081. doi: 10.1083/jcb.202112081.

7. Guo C^#, Peng Y^#, Lin L^#, Pan X^#, Fang M^#, Zhao Y, Bao K, Li R, Han J, Chen J, Song TZ, Feng XL, Zhou Y, Zhao G, Zhang L, Zheng Y, Zhu P, Hang H, Zhang L, Hua Z*,Deng H*, Hou B*. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates.Cell Rep Med. 2021 Nov 16;2(11):100448.

8. Xu G^#, Liu C^#, Zhou S^#, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S,Deng H*, Li D*, Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion.Mol Cell. 2021 Jul 1;81(13):2823-2837.e9.

9. Yu K, Tian H,Deng H*. PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion.Sci Adv. 2020 Nov 20;6(47):eabd0276.

10. Feng H^#, Tian H^#, Wang Y, Zhang Q, Lin N, Liu S, Yu Y,Deng H*, Gao P*. Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10.Proc Natl Acad Sci USA. 2020 Oct 27;117(43):26719-26727.

11. Lv Y^#, Shen S^#, Xiang L, Jia X, Hou Y, Wang D,Deng H*. Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus.J Virol. 2019 Nov 26;93(24):e01422-19.

12. Lv Y, Zhou S, Gao S,Deng H*. Remodeling of host membranes during herpesvirus assembly and egress.Protein Cell. 2019 May;10(5):315-326.

13. Gong D, Dai X, Xiao Y, Du Y, Chapa TJ, Johnson JR, Li X, Krogan NJ,Deng H, Wu TT, Sun R*. Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling.J Virol. 2017 Jul 12;91(15). e00362-17.

14. Jia X^#, Shen S^#, Lv Y, Zhang Z, Guo H,Deng H*. Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68.J Virol. 2016 Jul 27;90(16):7587-92.

15. Chen Y, He L, Shi X, Chen J, Zhong J, Chen X, Cheng G*,Deng H*. The hepatitis C virus protein NS3 suppresses TNF-a-stimulated activation of NF-kB by targeting LUBAC.Sci Signal. 2015 Nov 17;8(403): ra118.

16. Qi J^#, Han C^#, Gong D^#, Liu P, Zhou S, andDeng H*. Murine gammaherpesvirus 68 ORF48 is an RTA responsive gene product and functions in both viral lytic replication and latency during in vivo infection.J Virol. 2015 Jun 1;89(11):5788-800.

17. Shen S, Jia X, Guo H, andDeng H*. Gammaherpesvirus Tegument Protein ORF33 Is Associated with Intranuclear Capsids at an Early Stage of the Tegumentation Process.J Virol. 2015 May;89(10):5288-97.

18. Chen Y, Wang S, Yi Z, Tian H, Aliyari S, Li Y, Chen G, Liu P, Zhong J, Chen X, Du P, Su L, Qin FX,Deng H*, Cheng G*. Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms.Sci Rep. 2014 Dec 3; 4:7242.

19. Shen S, Guo H, andDeng H*. Murine gammaherpesvirus-68 ORF38 encodes a tegument protein and is packaged into virions during secondary envelopment.Protein Cell. 2014 Feb;5(2):141-50.

20. Xuan Y, Gong D, Qi J, Han C,Deng H*, Gao G*. ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA.J Virol. 2013 Mar;87(5):2735-43.

21. Xuan Y, Liu L, Shen S,Deng H*, Gao G*. Zinc-finger antiviral protein inhibits murine gammaherpesvirus-68 M2 expression and regulates viral latency in cultured cells.J Virol. 2012 Nov;86(22):12431-4.

22. Wang L, Guo H, Reyes N, Lee S, Bortz E, Guo F, Sun R, Tong L,Deng H*. Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment.J Virol. 2012 Feb;86(3):1348-57.

23. Hong Y^#, Qi J^#, Gong D, Han C,Deng H*. Replication and Transcription Activator (RTA) of Murine Gammaherpesvirus-68 Binds to An RTA-responsive Element and Activates the Expression of ORF18.J Virol. 2011 Nov;85(21):11338-50.

24. Lee S^#, Salwinski L^#, Zhang C, Chu D, Sampankanpanich C, Reyes NA, Vangeloff A, Xing F, Li X, Wu T, Sahasrabudhe S,Deng H, LaCount DJ*, Sun R*. An Integrated Approach to Elucidate the Intra-Viral and Viral-Cellular Protein Interaction Networks of a Gamma-Herpesvirus.PLoS Pathog. 2011 Oct; 7(10):e1002297.

25. Qi J, Gong D, andDeng H*. CCAAT/enhancer binding proteins play a role in oriLyt dependent genome replication during MHV-68 de novo infection.Protein Cell. 2011 Jun; 2(6):463-9.

26. Ding X^#, Yang W^#, Shi X, Du P, Su L, Qin Z*, Chen J*, andDeng H*. TNF Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms.J Immunol. 2011 Aug 1;187(3):1184-91.

27. Hong Y, Qi J, Gong D, Deng J,Deng H*. Identification of an RTA Responsive Element in Murine Gammaherpesvirus-68 Genome. Progress in Biochemistry and Biophysics. 2011;38(10):936-944.

28. Yang W^#, Ding X^#, Deng J^#, Lu Y, Matsuda Z, Thiel A, Chen J,Deng H*, Qin Z*. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection.J Mol Med. 2011 Apr;89(4):399-409.

2010年以前代表性论著

1. Guo H, Shen S, Wang L,Deng H*. Role of tegument proteins in herpesvirus assembly and egress.Protein Cell. 2010 Nov;1(11):987-98. (Invited review).

2. Guo H, Wang LL, Peng L, Zhou ZH, andDeng H*. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress.J Virol. 2009 Oct;83(20):10582-95.

3. Liao HI^#, Olson CA^#, Hwang S,Deng H, Wong E, Baric RS, Roberts RW, Sun R*. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein.J Biol Chem. 2009 Jun 26;284(26):17512-20.

4. Gong D, Qi J, Arumugaswami V, Sun R,Deng H*. Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus-68.Virology. 2009 May 10; 387(2):285-95.

5. Yang Z, Tang H, Huang H,Deng H*. RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivation.PloS One. 2009 4(2):e4556.

6. Lee S,Deng H*, Yu F, Melega WP, Damoiseaux R, Bradley KA, Sun R*. Regulation of Kaposi's sarcoma-associated herpesvirus Reactivation by Dopamine Receptor-Mediated Signaling Pathways.J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):531-40.

7. Benach J, Wang L, Chen Y, Ho CK, Lee S, Seetharaman J, Xiao R, Acton TB, Montelione GT,Deng H, Sun R*, Tong L*. Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus-68.J Biol Chem. 2007 Oct 26;282(43):31534-41. Epub 2007 Aug 15.

8. Bortz E, Wang L, Jia Q, Wu TT, Whitelegge JP,Deng H, Zhou ZH, Sun R*. Murine Gammaherpesvirus 68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm.J Virol. 2007 Sep;81(18):10137-50.

9.Deng H, Liang Y, Sun R. Regulation of KSHV lytic gene expression.Curr Top Microbiol Immunol. 2007;312:157-83. (Invited review).

10.Deng H*, Chu JT, Park NH, Sun R. Identification of cis-sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68.J Virol. 2004 Sep;78(17):9123-31.

11. Zhu J, Trang P, Kim K, Zhou T,Deng H, Liu F*. Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P.Proc Natl Acad Sci USA. 2004 Jun 15;101(24):9073-8. Epub 2004 Jun 7.

12.Deng H, Song MJ, Chu JT, Sun R*.Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus).J Virol. 2002 Aug;76(16):8252-64.

13.Deng H, Chu JT, Rettig MB, Martinez-Maza O, Sun R*. Rta of the human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.Blood. 2002 Sep 1;100(5):1919-21.

14. Varthakavi V, Smith RM,Deng H, Sun R, Spearman P*. Human Immunodeficiency Virus Type-1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus through Induction of KSHV Rta.Virology. 2002 Jun 5;297(2):270-80.

15.Deng H, Young A, Sun R*. Auto-activation of the rta gene of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus.J Gen Virol. 2000 Dec;81(Pt 12):3043-8.

16. Greenberg RA, O'Hagan RC,Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA*. Telomerase reverse transcriptase is a direct target of c-Myc but is not functionally equivalent in cellular transformation.Oncogene. 1999 Feb 4;18(5): 1219-26.

17.Deng H, Dewhurst S*. Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6.J Virol. 1998 Jan;72(1):320-9.

18. Secchiero P, Nicholas J,Deng H, Xiaopeng T, van Loon N, Ruvolo VR, Berneman ZN, Reitz MS Jr, Dewhurst S*. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity.J Virol. 1995 Dec;69(12):8041-5.

图书

1.《实验室生物安全》，2010，高等教育出版社。"十一五"国家重点图书。主要编委之一。

2.《中华医学百科全书-医学微生物学卷》，国家重点出版工程。负责编写疱疹病毒科条目的唯一编委。

3.《医学病毒学原理》，2020，化学工业出版社。第十五章，疱疹病毒。

（资料来源：邓红雨研究员，2024-09-14）

在职职工

田华彬，副研究员

本科毕业于河北农业大学，硕士毕业于中国农业科学院，他于2017年获得中国科学院生物物理研究所博士学位。目前是邓红雨课题组的副研究员，专注于病毒与天然免疫系统间的相互作用。
刘淑君，高级实验师

本科毕业于河北大学，硕士毕业于山东大学。她于2015年加入邓老师的实验室，目前是邓红雨课题组的高级实验师，主要负责课题组的日常管理及科研支撑等工作。
彭亚男，助理研究员

本科和硕士都毕业于山西大学，她于2018年获得中国科学院生物物理研究所博士学位。目前是邓红雨课题组的助理研究员，专注于新型疫苗的研发。