刘超培
/ 博士 研究员 博士生导师
中国科学院生物物理研究所，表观遗传调控与干预重点实验室，研究组长 中国科学院青年创新促进会会员
简历
2001 - 2005 湖南师范大学物理学 学士
2005 - 2010 中国科学院高能物理研究所 博士
2010 - 2013 中国科学院生物物理研究所 博士后
2013 - 2021 中国科学院生物物理研究所 副研究员
2022 - 2023 中国科学院生物物理研究所 研究员
2024 - 至今 中国科学院生物物理研究所 研究员，研究组长
获奖及荣誉
社会任职
承担项目情况
本研究组主要从事染色质组装与调控的结构生物学研究，具体分两个方面：
1. DNA复制偶联的染色质组装机理
伴随DNA复制的染色质组装是真核生物细胞继承与可塑性的核心机制，涉及复制机器与组蛋白伴侣、修饰酶等表观遗传因子之间复杂而精密地联动。解析复制偶联关键蛋白复合体的结构与功能，将为理解染色质复制过程中表观遗传信息的继承提供重要认知，并为探索抗肿瘤新策略提供结构框架。
2. 减数分裂同源染色体联会的分子机理
减数分裂联会复合体与程序性DNA双链断裂（DSB）的产生和修复之间相互调控，确保同源染色体正确的识别、配对、重组和分离，以实现遗传物质在生物世代间的稳定传递和生物的遗传多样性。解析减数分裂重组调控的分子基础，将为生殖健康的精准治疗提供重要的结构参考。
1.Chao-Pei Liu#*, Zhenyu Yu#, Jun Xiong#, Jie Hu#, Aoqun Song#, Dongbo Ding#, Cong Yu, Na Yang, Mingzhu Wang, Juan Yu, Peini Hou, Kangning Zeng, Zhenyu Li, Zhuqiang Zhang, Xinzheng Zhang, Wei Li, Zhiguo Zhang, Bing Zhu*, Guohong Li*, and Rui-Ming Xu*. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.Science, 2023, 381(6660): eadd8673.
2. Weiran Ge#, Cong Yu#, Jingjing Li#, Zhenyu Yu, Xiaorong Li, Yan Zhang,Chao-Pei Liu, Yingfeng Li, Changlin Tian, Xinzheng Zhang, Guohong Li, Bing Zhu*, and Rui-Ming Xu*. Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.Nature, 2023, 616(7955):176-182.
3. Ye Yue#, Wen-Si Yang#, Lin Zhang,Chao-Pei Liu, and Rui-Ming Xu. Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex.Genes & Development, 2022, 36(7-8):408-413.
4. Hui Wang#, Boyuan Li#, Linyu Zuo, Bo Wang, Yan Yan, Kai Tian, Rong Zhou, Chenlu Wang, Xizi Chen, Yongpeng Jiang, Haonan Zheng, Fangfei Qin, Bin Zhang, Yang Yu,Chao-Pei Liu, Yanhui Xu, Juntao Gao, Zhi Qi, Wulan Deng, and Xiong Ji. The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.Nature Communications, 2022, 13(1):5703.
5. Jing Zhang#, Yan Zhang#, Qinglong You#, Chang Huang, Tiantian Zhang, Mingzhu Wang, Tianwei Zhang, Xiaocheng Yang, Jun Xiong, Yingfeng Li,Chao-Pei Liu, Zhuqiang Zhang, Rui-Ming Xu*, and Bing Zhu*. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.Science, 2022, 375(6584):1053-1058.
6.Chao-Pei Liu#*, Wenxing Jin#, Jie Hu, Mingzhu Wang, Jingjing Chen, Guohong Li, and Rui-Ming Xu*. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones.Genes & Development, 2021, 35(23-24):1610-1624.
7. Wenxing Jin#, Jia Wang#,Chao-Pei Liu, Hong-Wei Wang*, and Rui-Ming Xu*. Structural Basis for pri-miRNA Recognition by Drosha.Molecular Cell, 2020, 78(3):423-433.e5.
8. Peini Hou#, Chang Huang#,Chao-Pei Liu, Na Yang, Tianshu Yu, Yuxin Yin, Bing Zhu*, and Rui-Ming Xu*. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding.Structure, 2019, 27(5):837-845.e3.
9. Chaoyang Xiong#, Zengqi Wen#, Juan Yu, Jun Chen,Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, and Guohong Li. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells.BMC Biology, 2018, 16(1):110.
10. Wenxing Jin#, Yi Wang#,Chao-Pei Liu#, Na Yang, Mingliang Jin, Yao Cong, Mingzhu Wang* and Rui-Ming Xu*. Structural basis for snRNA recognition by the double WD40-repeat domain of Gemin5.Genes & Development, 2016, 30(21): 2391-2403.
11.Chao-Pei Liu#, Chaoyang Xiong#, Mingzhu Wang, Zhouliang Yu, Na Yang,Ping Chen, Zhiguo Zhang, Guohong Li* and Rui-Ming Xu*. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.Nature Structural & Molecular Biology, 2012, 19(12): 1287-1292.
（资料来源：刘超培研究员，2024-02-22）
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