李梅
/ 博士 研究员
中国科学院生物物理研究所，生物大分子重点实验室，研究组长
研究方向：
光合作用相关（膜）蛋白及复合物的结构与功能
电子邮件：
meili@ibp.ac.cn
电 话：
010-64888511
通讯地址：
北京市朝阳区大屯路15号（100101）
英文版个人网页：
http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmL/202005/t20200519_341400.html
简历
1991.09 - 1995.07 天津市南开大学，获理学学士学位
1999.09 - 2002.07 中国科学院生物物理研究所，获理学硕士学位
2004.09 - 2007.07 中国科学院生物物理研究所，获理学博士学位
1995.07 - 1999.06 中国科学院生物物理研究所，研究实习员
1999.07 - 2004.06 中国科学院生物物理研究所，助理研究员
2007.07 - 2016.12 中国科学院生物物理研究所，副研究员
2016.12 - 至今 中国科学院生物物理研究所，研究员
获奖及荣誉
社会任职
承担项目情况
光合作用是地球上最重要的化学反应之一，放氧光合生物利用太阳能，将二氧化碳转变为有机物，同时释放氧气，为地球上几乎全部生物提供物质能量来源。光合作用分为光反应和暗反应两个阶段。光反应是在光合生物的类囊体膜上进行的，由5个超大的膜蛋白复合物共同完成，光反应过程中产生的ATP和NADPH被后续的暗反应利用，最终生成碳水化合物。对光合作用机理及其调控机制的研究有望为解决当前面临的粮食、能源、环境等问题提供解决方案。
现阶段的研究内容主要集中在以下三个方面：
1. 光反应途径相关膜蛋白及复合物的结构与功能研究；
2. 光合生物对其捕光及电子传递的调节机理；
3. 光合作用暗反应中关键酶及其调控系统的结构与功能研究。
1. Zhang S1, Zou B1, Cao P, Su X, Xie F, Pan X,Li M*. Structural insights into photosynthetic cyclic electron transport.Mol Plant. 2023 Jan; 16(1): 187-205.
2. Wang J, Liu Z, Pan X, Wang N, Li L, Du Y, Li J*,Li M*. Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082.Marine Drugs2022 20(8): 533.
3. Yu G1, Hao J1, Pan X1, Shi L, Zhang Y, Wang J, Fan H, Xiao Y, Yang F, Lou J, Chang W, Malnoe A*,Li M*. Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH.Nat Plants. 2022 July; 8:840-855.
4. Su X1, Cao D1, Pan X*, Shi L, Liu Z, Dall'Osto L, Bassi R, Zhang X*,Li M*. Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana.Mol Plant. 2022 Mar; 15(3):454-467. doi: 10.1016/j.molp.2022.01.020.
5. Cao P1, Bracun L1, Yamagata A1, Christianson B, Negami T, Zou B, Terada T, Canniffe D, Shirouzu M*,Li M*, Liu LN*. Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC-LH1 supercomplex.Nat Commun. 2022 Apr; 13(1):1977. doi: 10.1038/s41467-022-29563-3.
6. Pan X1, Tokutsu R1, Li A1, Takizawa K, Song C, Murata K, Yamasaki T, Liu Z*, Minagawa J* andLi M*. Structural basis of LhcbM5-mediated state transitions in green algae.Nat. Plants, 2021 Jul; 7:1119–1131.
7. Cao P, Pan X, Su X, Liu Z,Li M*. Assembly of eukaryotic photosystem II with diverse light-harvesting antennas.Curr Opin Struct Biol. 2020 Aug;63:49-57.
8. Yu A1; Xie Y1; Pan X; Zhang H; Cao P; Su X; Chang W;Li M*. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle.Plant Cell. 2020 May;32(5):1556-1573.
9. Gao Y1; Zhang H1; Fan M; Jia C; Shi L; Pan X; Cao P; Zhao X; Chang W;Li M*. Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.Nat Commun., 2020 Mar 23, 11:1525
10. Cao P1; Cao D1; Si L; Su X; Tian L; Chang W; Liu Z; Zhang X*;Li M*. Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex,Nature Plants. 2020 Feb 10, 6:167~176
11. Pan X1; Cao D1; Xie F1; Xu F1; Su X; Mi H; Zhang X*;Li M*. Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase.Nat Commun., 2020 Jan 30, 11(1):610
12. Pan X; Cao P; Su X; Liu Z;Li M*. Structural analysis and comparison of light-harvesting complexes I and II.BBA-Bioenergetics. 2020 Apr 1, 1861(4): 148038.
13. Su X1, Ma J1, Pan X1, Zhao X, Chang W, Liu Z, Zhang X*,Li M*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex.Nat Plants. 2019 2019 Mar 8; 5: 273~281
14. Pan X1, Ma J1, Su X1, Cao P, Chang W, Liu Z, Zhang X*,Li M*. Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II.Science. 2018, 360(6393):1109-1113.
15. Cao P, Su X, Pan X, Liu Z, Chang W,Li M*. Structure, assembly and energy transfer of plant photosystem II supercomplex.Biochim Biophys Acta Bioenerg. 2018, 1859(9):633-644.
16. Su X1, Ma J1, Wei X1, Cao P1, Zhu D, Chang W, Liu Z*, Zhang X*,Li M*.Structure and assembly mechanism of plant C(2)S(2)M(2)-type PSII-LHCII supercomplex.Science. 2017, 357(6353):815-820.
17. Wei X1, Su X1, Cao P, Liu X,Chang W,Li M*,Zhang X*, Liu Z*. Structure of spinach photosystem II-LHCII supercomplex at 3.2 Å resolution. Nature. 2016, 534(7605):69-74.
18. Fan M1, Xiao Y1,Li M*,Chang W*. Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation.Molecular Plant. 2016 9(9):1349-52
19. Fan M,Li M*, Liu Z, Cao P, Pan X, Zhang H, Zhao X, Zhang J, Chang W*. Crystal structures of the PsbS protein essential for photoprotection in plants.Nature Structural & Molecular Biology, 2015, 22(9):729-735.
20. Cao P1, Xie Y1,Li M*,Pan X, Zhang H, Zhao X, Su X, Cheng T,Chang W*. Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese-Induced Conformational Change.Molecular Plant, 2015,8, 664–666.
21. Jia C,Li M*,Li J, Zhang J, Zhang H, Cao P, Pan X, Lu X*, Chang W*. Structural insights into the catalytic mechanism of aldehyde-deformylating Oxygenases.Protein Cell, 2015, 6(1):55–67.
22. Zhang H,Li M*,Gao Y, Jia C, Pan X, Cao P, Zhao X, Zhang J, Chang W*. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation.Protein Cell. 2015 Feb;6(2):147-51.
23. Wan T,Li M*,Zhao X, Zhang J, Liu Z, Chang W*. Crystal structure of a multilayer packed major light-harvesting complex: implications for grana stacking in higher plants.Molecular Plant. 2014 May;7(5):916-9.
（资料来源：李梅研究员，2023-06-29）
工作人员
研究生
离职人员
毕业学生