发表论文

1. Na Zhang, Zunling Zhao, Yin Zhao, Lei Yang, Yanhong Xue, Yun Feng, Jianjun Luo, Runsheng Chen, Wei Wei &Yan Qin*(2023). TGF-Beta changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy.Signal Transduction and Targeted Therapy.https://www.nature.com/articles/s41392-023-01370-2(IF 38.12)

2. Li H, Huo Y, He X, Yao L, Zhang H, Cui Y, Xiao H, Xie W, Zhang D, Wang Y, Zhang S, Tu H, Cheng Y, Guo Y, Cao X, Zhu Y, Jiang T, Guo X*,  Qin Y*& Sha J*(2022). A male germ-cell-specific ribosome controls male fertility.Nature.https://doi.org/10.1038/s41586-022-05508-0（IF 69.504）

3. Yang B, Zhang Y, Sun L, Wang J, Zhao Z, Huang Z, Mao W, Xue R, Chen R, Luo J*, Wang T*, Jiang J*,Qin Y*(2022) (*corresponding author) Modulated Ultrasmall γ-Fe₂O₃Nanocrystal Assemblies for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy.Advanced Functional Materials.https://doi.org/10.1002/adfm.202211251（IF 19.924）

4. Wang J, Yang B, Lv C, Chen T, Sun L, Sun L, Hao J, Ding F*, Wang T*, Jiang J* andQin Y*(2022) (*corresponding author). Amino porphyrin-peptide assemblies induce ribosome damage and cancer stem cell inhibition for an enhanced photodynamic therapy.Biomaterials.https://doi.org/10.1016/j.biomaterials.2022.121812（IF 15.304）

5. Wang Q, Wang Y, Li S, Zhou A andQin Y*(2022) (*corresponding author). Organelle biogenesis: Ribosomes as organizer and performer.Science Bulletin.https://doi.org/10.1016/j.scib.2022.07.023(IF 20.577)

6. Zhang K, Jiao X, Zhou L, Wang C*,Qin Y*, Wen Y* (2021) (*corresponding author). Nanofibrous composite aerogel with multi-bioactive and fluid gating characteristics for promoting diabetic wound healing.Biomaterials.https://doi.org/10.1016/j.biomaterials.2021.121040（IF 15.304）

7. Wu H*, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X,Qin Y, Liu L*, and Chen Q* (2020) (*corresponding author). Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.Redox Biol.https://doi.org/10.1016/j.redox.2020.101661（IF 10.787）

8. Zhang M, et al.,Qin Y, …Chen L*, Hanna JH* and Esteban MA* (2020) (*corresponding author). β-catenin safeguards the ground state of pluripotency by strengthening the robustness of the transcriptional apparatus.Sci. Adv.https://www.science.org/doi/10.1126/sciadv.aba1593（IF 14.98）

9. Song G, Xu B, Shi H, Zhang Y, Zhang D, Cao X, Liu Z, Guo R, Guan Y, Chu Y, Zhang X*, Lou J*, andQin Y*. (2020) (*corresponding author). Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF.International Journal of Biological Macromolecules.https://doi.org/10.1016/j.ijbiomac.2020.05.254（IF 8.025）

10. Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X,Qin Y*, Wen Y* and Zhang X. (2020) (*corresponding author). Cellular Nanofiber Structure with Secretory Activity-Promoting Characteristics for Multicellular Spheroid Formation and Hair Follicle Regeneration.ACS Appl. Mater. Interfaces.https://doi.org/10.1021/acsami.9b21125(IF 8.456)

11. Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X,Qin Y*, Wen Y* and Zhang X (2019) (*corresponding author). Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing.Biomateirals. (204 (2019) 70-79).https://doi.org/10.1016/j.biomaterials.2019.03.008(IF 10.273)

12. Zhou Z, Hu Y, Li A, Li Y, Zhao H, Wang S, Otecko NO, Zhang D, Wang J, Liu Y, Irwin DM,Qin Y& Ya-Ping Zhang* (2018). Genome wide analyses uncover allele-specific RNA editing in human and mouse.Nucleic Acids Res.https://doi.org/10.1093/nar/gky613（IF 19.16）

13. Wang F, Zhang L, Bai X, Cao X, Jiao X, Huang Y, Li Y,Qin Y*and Wen Y* (2018) (*corresponding author). Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer.ACS Applied Materials & Interfaces.https://doi.org/10.1021/acsami.8b07698（IF 10.383）

14. Zhu P, Liu Y, Zhang F, Bai X, Chen Z, Shangguan F, Zhang B, Zhang L, Chen Q, Xie D, Lan L, Xue X, Liang X, LU B, Wei T,Qin Y*(2018) (*corresponding author). Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch.Cancer Research.https://doi.org/10.1158/0008-5472.CAN-17-2059  （IF 9.122）

15. Gao Y, Bai X, Zhang D, Han C,Yuan J, Liu W, Cao X, Chen Z, Shangguan F, Zhu Z, Gao F andQin Y*(2016) (*corresponding author). Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis.Nat Struct Mol Biol.https://www.nature.com/articles/nsmb.3206（IF 18.361）

16. Zhang D, Kaige Y, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Lou Z, Gao N* andQin Y*(2016) (*corresponding author). EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome.Nat Struct Mol Biol.https://www.nature.com/articles/nsmb（IF 13.309）

17. Zhang D, Kaige Y, Zhang Y, Liu G, Cao X, Song G, Xie Q*, Gao N*,Qin Y*(2015) (*corresponding author). New insights into the enzymatic role of EF-G in ribosome recycling.Nucleic Acids Res.https://doi.org/10.1093/nar/gkv995（IF 19.16）

18. Liu G, Zhang D, Song G, Li Z, Zhang D, Lyv Z, Aachenbach J, Dong J, Gong W, Zhao X, Nierhaus K H andQin Y*(2014) (*corresponding author). EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex.Nat Struct Mol Biol.https://www.nature.com/articles/nsmb.2869（IF 13.309）

19. Yamamoto H*,Qin Y*, Achenhach J*, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (*co-first author). EF-G and EF4: Translocation and back-translocation on the bacterial ribosome.Nature Reviews Microbiology.https://www.nature.com/articles/nrmicro3176（IF 22.49）

20. Zhang D, Liu G, Xue J, Lou J, Nierhaus K H, Gong W* andQin Y*(2012) (*corresponding author). Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosome.Nucleic Acids Res.https://doi.org/10.1093/nar/gks833（IF 8.02）

21. Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W andQin Y*(2012) (*corresponding author). A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases.Nat. Struct. Mol. Biol.https://www.nature.com/articles/nsmb（IF 12.712）

22. Di Giacco V*, Marquez V*,Qin Y*, Pech M, Triana-Alonso FJ, Wilson DN, Nierhaus KH (2008) (*co-first author). Shine-dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG.PNAS.https://doi.org/10.1073/pnas.0801974105（IF 9.681）

23. Connell SR*, Topf M*,Qin Y*, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM (2008) (*co-first author). A new trna intermediate revealed on the ribosome during ef4-mediated back-translocation.Nature Struct. Mol. Biol.https://www.nature.com/articles/nsmb（IF 12.712）

24.Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH (2006). The highly conserved lepa is a ribosomal elongation factor that back-translocates the ribosome.Cell.  https://doi.org/10.1016/j.cell.2006.09.037（IF 32.403）

专      利

1. Knud H Nierhaus,Yan Qin, Daniel Wilson. The protein factor LepA (EF4) as a new target for antibiotics against bacteria.PCT/EP 2007/008961

2. Knud H Nierhaus,Yan Qin, Daniel Wilson. Use of LepA for improving the accuracy of protein synthesis in vitro.PCT/EP 2006/006503

3.Yan Qin, Yanyan Gao. Usage of the mitochondrial translation factor Guf1 in Male sterility study.2013104852275

4.秦燕，郝佳，朱萍。EF4蛋白编码基因沉默在癌症治疗方面的应用（申请号：201210566942.7，证书号：第2369805号）（已授权）

5.秦燕，高岩岩。线粒体蛋白质翻译因子mtEF4/Guf1在雄性不育研究中的应用（申请号：201310485227.5，证书号：第1812912号）（已授权）

6.秦燕，白秀峰  “用于毛发生长和诊断脱发生物标志物” （专利号：ZL2020 1 0024593.0，证书号：第5390470号）（已授权）

7.秦燕，赵遵岭，张娜，魏巍 “特发性肺纤维化诊断”（专利审查中）

8.秦燕，孙立欣，黄卓越  “一种水凝胶及其制备方法和用途作为杀伤肿瘤核糖体的应用” （申请中）

（资料来源：秦燕研究员，2023-03-22）