Recent Research Activities

Q. Fang, P. Chen, M. Wang, J. Fang, N. Yang, G. Li,and R.M. Xu(2016) Human cytomegalovirus IE1 protein alters the higher order chromatin structure by targeting the acidic patch of the nucleosome.eLife5, e11911.

N. Yang, Z. Yu, M. Hu, M. Wang, R. Lehmann, andR.M. Xu(2015) Structure of Drosophila Oskar reveals a novel RNA binding protein.Proc. Natl. Acad. Sci. USA112, 11541-11546.

D. Cao, M. Wang, X. Qiu, D. Liu, H. Jiang, N. Yang, andR.M. Xu(2015) Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol.Genes & Dev.29, 1316-1325.

T. Zhou, J. Xiong, M. Wang, N. Yang, J. Wong, B. Zhu, andR.M. Xu(2014) Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.Mol. Cell54, 879-886.

R. Ren, H. Liu, W. Wang, M. Wang, N. Yang, Y.H. Dong, W. Gong, R. Lehmann, andR.M. Xu(2014)Structure and domain organization of Drosophila Tudor.Cell Res.24, 1146-1149.

F. Song, P. Chen, D. Sun, M. Wang, L. Dong, D. Liang,R.M. Xu, P. Zhu, and G. Li (2014) Cryo-EM study reveals a double helix of the 30 nm chromatin fiber twisted by tetra-nucleosomal units.Science344, 376-380.

H. Liu, J.Y. Wang, Y. Huang, Z. Li, W. Gong, R. Lehmann, andR.M. Xu(2010) Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.Genes & Dev24, 1876-81.

Q. Qiao, Y. Li, Z. Chen, M. Wang, D. Reinberg, andR.M. Xu(2011) The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.J. Biol. Chem.286, 8361-8.

H. Hu, Y. Liu, M. Wang, J. Fang, H. Huang, N. Yang, Y. Li, J. Wang, X. Yao, Y. Shi, G. Li, andR.M. Xu(2011) Structure of a CENP-A-Histone H4 heterodimer in complex with chaperone HJURP.Genes & Dev.25, 901-6.

L. Sun, M. Wang, Z. Lv, N. Yang, Y. Liu, S. Bao, W. Gong, andR.M. Xu(2011) Structural insights into protein arginine symmetric dimethylation by PRMT5.Proc. Natl. Acad. Sci. USA108, 20538-20543.

P.C. Lin, andR.M. Xu(2012) Structure and assembly of the SF3a splicing factor complex of U2 snRNP.EMBO J.31, 1579-1590.

N. Yang, W. Wang, Y. Wang, M. Wang, Q. Zhao, Z. Rao, B. Zhu, andR.M. Xu(2012) Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.Proc. Natl. Acad. Sci. USA109, 17954-17959.

C.P. Liu, C. Xiong, M. Wang, Z. Yu, N. Yang, P. Chen, Z. Zhang, G. Li, andR.M. Xu(2012) Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX,Nat. Struct. Mol. Biol.19, 1287-1292..

N. Yang andR.M. Xu(2013) Structure and function of the BAH domain in chromatin biology.Crit. Rev. Biochem. Mol. Biol.48, 211-221.

D. Yang, Q. Fang, M. Wang, R. Ren, H. Wang, M. He, Y. Sun, N. Yang, andR.M. Xu(2013) Na-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.Nat. Struct. Mol. Biol.20, 116-118.

H.C. Hsu, C.L. Wang, M. Wang, N. Yang, Z. Chen, R. Sternglanz, andR.M. Xu(2013) Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding.Genes & Dev.27, 64-73.

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