Selected Peer Reviewed Publications

(64) W.Q. Fu, N. Liu, Q. Qiao, M. Wang, J.R. Min, B. Zhu, R.M. Xu and N. Yang(2016) Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase. J. Biol. Chem., Vol. 291, 9173-9180.
(63) Q. Fang, P. Chen, M. Wang, J. Fang, N. Yang, G. Li, and R.M. Xu (2015) Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. elife, 5, e11911.
(62) N. Yang, Z. Yu, M. Hu, M. Wang, R. Lehmann, and R.M. Xu (2015) Structure of Drosophila Oskar reveals a novel RNA binding protein. Proc. Natl. Acad. Sci. USA 112, 11541-11546.
(61) G. Gao, M. Wang, N. Yang, Y. Huang, and R.M. Xu (2015) Structure of Zeste-DNA complex reveals a new modality of DNA recognition by homeodomain-like proteins. J. Mol. Biol. 427, 3824-3833.
(60) D. Cao, M. Wang, X. Qiu, D. Liu, H. Jiang, N. Yang, and R.M. Xu (2015) Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol. Genes & Dev. 29, 1316-1325.
(59) H. Wang, M. Wang, N. Yang, and R.M. Xu (2015) Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein & Cell 6, 693-697.
(58) J. Fang, Y. Wei, Y. Liu, W. Deng, Z. Yu, L. Huang, Y. Teng, T. Yao, Q. You, H. Ruan, P. Chen, R.M. Xu, and G. Li (2015) Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N. Genes & Dev. 29, 1058-1073.
(57) Z . Yu, X. Zhou, W. Wang, W. Deng, J. Fang, H. Hu, Z. Wang, S. Li, L. Cui, J. Shen, L. Zhai, S. Peng, J. Wong, S. Dong, Z. Yuan, G. Ou, X. Zhang, P. Xu, J. Lou, N. Yang, P. Chen, R.M. Xu, and G. Li (2015) Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell cycle-dependent deposition at centromeres. Dev. Cell 32, 68-81.
(56) D. Cao and N. Yang* (2015) Structure and catalytic mechanisms of histone deacetylases. Progress in Biochemistry and Biophysics, Vol. 42, 1-16.
(55) T. Zhou, J. Xiong, M. Wang, N. Yang, J. Wong, B. Zhu, and R.M. Xu (2014) Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. Mol. Cell 54, 879-886.
(54) R. Ren, H. Liu, W. Wang, M. Wang, N. Yang, Y.H. Dong, W. Gong, R. Lehmann, and R.M. Xu（2014）Structure and domain organization of Drosophila Tudor. Cell Res. 24, 1146-1149.
(53) N. Yang and R.M. Xu (2014) Structural Basis for Methyl DNA Readout by MBD and SRA Domains. Progress in Biochemistry and Biophysics 41, 1063-1074.
(52) F. Song, P. Chen, D. Sun, M. Wang, L. Dong, D. Liang, R.M. Xu, P. Zhu, and G. Li (2014) Cryo-EM study reveals a double helix of the 30 nm chromatin fiber twisted by tetra-nucleosomal units. Science 344, 376-380.
(51) Y. Li, L. Zhang, T. Liu, C. Chai, Q. Fang, H. Wu, Garcia. Agudelo PA, Z. Han, S. Zong, Y. Yu, X. Zhang, M.R. Parthun, J. Chai, R.M. Xu, and M. Yang (2014) Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex. Genes & Dev. 28, 1217-1227.
(50) M. Wang, R.M. Xu, and P.R. Thompson (2013) Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. Biochemistry 52, 5430-40.
(49) D. Yang, Q. Fang, M. Wang, R. Ren, H. Wang, M. He, Y. Sun, N. Yang, and R.M. Xu (2013) N-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat. Struct. Mol. Biol. 20, 116-118.
(48) N. Yang and R.M. Xu (2013) Structure and function of the BAH domain in chromatin biology. Crit. Rev. Biochem. Mol. Biol. 48, 211-221.
(47) H.C. Hsu, C.L. Wang, M. Wang, N. Yang, Z. Chen, R. Sternglanz, and R.M. Xu (2013) Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. Genes & Dev. 27, 64-73.
(46) C.P. Liu, C. Xiong, M. Wang, Z. Yu, N. Yang, P. Chen, Z. Zhang, G. Li, and R.M. Xu (2012) Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX, Nat. Struct. Mol. Biol. 19, 1287-1292.
(45) N. Yang, W. Wang, Y. Wang, M. Wang, Q. Zhao, Z. Rao, B. Zhu, and R.M. Xu (2012) Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci. USA 109, 17954-17959.
(44) L. Wang, F. Wang, D. Zhang, Z. Chen, R.M. Xu, K.H. Nierhaus, W. Gong, and Y. Qin (2012) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nat. Struct. Mol. Biol. 19, 403-410.
(43) P.C. Lin, and R.M. Xu (2012) Structure and assembly of the SF3a splicing factor complex of U2 snRNP. EMBO J. 31, 1579-1590.
(42) K. Liu, C. Bian, H. Liu, Y. Guo, R. Lam, F. MacKenzie, L.A. Rojas, D. Reinberg, M. Bedford, R.M. Xu*, and J. Min* (2012) Crystal structure of TDRD3 and methyl-arginine binding characterizations of TDRD3, SMN and SPF30. PLoS ONE 7, e30375. *Co-corresponding authors.
(41) L. Sun, M. Wang, Z. Lv, N. Yang, Y. Liu, S. Bao, W. Gong, and R.M. Xu (2011) Structural insights into protein arginine symmetric dimethylation by PRMT5. Proc. Natl. Acad. Sci. USA 108, 20538-20543.
(40) W. Wang, Z. Chen, Z. Mao, H. Zhang, X. Ding, S. Chen, X. Zhang, R.M. Xu, B. Zhu (2011) Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 12, 1160-1166.
(39) H. Hu, Y. Liu, M. Wang, J. Fang, H. Huang, N. Yang, Y. Li, J. Wang, X. Yao, Y. Shi, G. Li, and R.M. Xu (2011) Structure of a CENP-A-Histone H4 heterodimer in complex with chaperone HJURP. Genes & Dev. 25, 901-6.
(38) D. Su, Q. Hu, H. Zhou, J.R. Thompson, R.M. Xu, Z. Zhang, and G. Mer (2011) Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex. J. Biol. Chem. 286, 15625-9.
(37) Q. Qiao, Y. Li, Z. Chen, M. Wang, D. Reinberg, and R.M. Xu (2011) The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J. Biol. Chem. 286, 8361-8.
(36) H. Liu, J.Y. Wang, Y. Huang, Z. Li, W. Gong, R. Lehmann, and R.M. Xu (2010) Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. Genes & Dev 24, 1876-81.
(35) Y. Li, P. Trojer, C.F. Xu, P. Cheung, A. Kuo, W.J. 3rd, Drury, Q. Qiao, T.A. Neubert, R.M. Xu, O. Gozani, and D. Reinberg (2009) The target of the NSD family of histone lysine methyl transferases depends on the nature of the substrate. J. Biol. Chem. 284, 34283-95.
(34) M.K. Hayashi, C. Tang, C. Verpelli, R. Narayanan, M.H. Sterns, R.M. Xu, H. Li, C. Sala, and Y. Hayashi (2009) Structural framework of the postsynaptic density formed by a high-order complex between Homer and Shank. Cell 137, 159-171.
(33) H.P. Harding, J.G. Lackey, H.C. Hsu, Y. Zhang, J. Deng, R.M. Xu, M.J. Dhama, and D. Ron (2008) An intact unfolded protein response in Trpt1 knockout mice reveals phylogenetic divergence in pathways for RNA ligation. RNA 14, 225-232.
(32) J. Han, H. Zhou, Z. Li, R.M. Xu, and Z. Zhang (2007) Acetylation of lysine 56 of histone H3 catalyzed by Rtt109 and regulated by Asf1 is required for replisome integrity. J. Biol. Chem. 282, 28587-28596.
(31) X. Yang, J. Zhou, L. Sun, Z. Wei, J. Gao, W. Gong, R.M. Xu, Z. Rao, and Y. Liu (2007) Structural basis for DCN-1's function in protein neddylation. J. Biol. Chem. 282, 24490-24494.
(30) J. Han, H. Zhou, Z. Li, R.M. Xu, and Z. Zhang (2007) The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J. Biol. Chem. 282, 14158-14164.
(29) J. Han, H. Zhou, B. Horazdovsky, K. Zhang, R.M. Xu, and Z. Zhang (2007) Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science 315, 653-655.
(28) Z. Li, R. Cao, M. Wang, M.P. Myers, Y. Zhang, and R.M. Xu (2006) Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex. J. Biol. Chem. 281, 20643-20649.
(27) Y. Huang, J. Fang, M.T. Bedford, Y, Zhang, and R.M. Xu (2006) Recognition of histone H3 Lysine-4 methylation by the double tudor domain of JMJD2A. Science 312, 748-751.
(26) Q.-S. Zhang, L. Manche, R.M. Xu, and A. R. Krainer (2006) HnRNP A1 associates with telomere ends and stimulates telomerase activity by facilitating the translocation step. RNA 12, 1116-1128.
(25) J.J. Connelly, P. Yuan, H.C. Hsu, Z. Li, R.M. Xu*, and R. Sternglanz* (2006) Structure and function of the yeast Sir3 BAH domain. Mol. Cell Biol. 26, 3256-3265. *Co-corresponding authors.
(24) Y. Huang, M.P. Myers, and R.M. Xu (2006) Structure of the EMSY-HP1 complex reveals a new mode of HP1 binding. Structure 14, 703-712.
(23) G. Hu, G. Lin, M. Wang, J. Jiang, R.M. Xu, C. Nathan, and H. Li (2006) Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Mol. Microbiology 59, 1417-1428.
(22) H.C. Hsu, B. Stillman, and R.M. Xu (2005) Structural basis for origin recognition complex 1 protein-silencing regulator 1 protein interaction in epigenetic silencing. Proc. Natl. Acad. Sci. USA 102, 8519-8524.
(21) H. Shi, O. Cordin, C.M. Minder, P. Linder, and R.M. Xu (2004) Crystal structure of the human ATP-dependent splicing and export factor UAP56. Proc. Natl. Acad. Sci. USA 101, 17628-17633.
(20) H. Chiodi, M. Corioni, M. Giordano, R. Valgardsdottir, F. Cobianchi, R.M. Xu, S. Riva, and G. Biamonti (2004) RNA binding domain 2 directs the recruitment of SF2/ASF to nuclear stress bodies. Nucleic Acids Res. 32, 4127-4136.
(19) J. Landry, A. Sutton, T. Hesman, J. Min, R.M. Xu, M. Johnston, and R. Sternglanz (2003) Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in S. cerevisiae. Mol. Cell Biol. 23, 5972-5978.
(18) J. Min, Y. Zhang, and R.M. Xu (2003) Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at lysine 27. Genes & Dev. 17, 1823-1828.
(17) H. Shi and R.M. Xu (2003) Crystal structure of the Drosophila Mago nashi -Y14 complex. Genes & Dev. 17, 971-976.
(16) J. Min, Q. Feng, Z. Li, Y, Zhang, and R.M. Xu (2003) Structure of the catalytic domain of human Dot1L, a non-SET domain nucleosomal histone methyltransferase. Cell 112, 711-723.
(15) J. Min, X. Zhang, X. Cheng, S.I. Grewal, and R.M. Xu (2002) Structure of the SET domain histone lysine methyltransferase Clr4. Nat. Struct. Biol. 9, 828-832.
(14) H.H Ng, R.M. Xu, Y. Zhang, and K. Struhl (2002) Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3-Lysine 79. J. Biol. Chem. 277, 34655-34657.
(13) Z. Zhang, M.K. Hayashi, O. Merkel, B. Stillman, and R.M. Xu (2002) Structure and function of the BAH domain of ORC1 in transcriptional silencing. EMBO J. 21, 4600-4611.
(12) J. Vitali, J. Ding, J. Jiang, Y. Zhang, A.R. Krainer, and R.M. Xu (2002) Correlated Alternative Side-chain Conformations in the RNA-Recognition Motif of hnRNP A1. Nucleic Acids Res. 30, 1531-1538.
(11) J. Min, J. Landry, R. Sternglanz, and R.M. Xu (2001) Crystal structure of a SIR2 homolog-NAD complex. Cell 105, 269-279.
(10) J. Jiang, D.S. Horowitz, and R.M. Xu (2000) Crystal structure of the functional domain of the splicing factor Prp18. Proc. Natl. Acad. Sci. USA 97, 3022-3027.
(9) J.P.J. Chong, M.K. Hayashi, M.N. Simon, R.M. Xu, and B. Stillman (2000) A double hexamer archaeal minichromosome maintenance protein is an ATP dependent DNA helicase. Proc. Natl. Acad. Sci. USA 97, 1530-1535.
(8) J. Ding, M.K. Hayashi, A.R. Krainer, and R.M. Xu (1999) Crystal structure of the two-RRM domain hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes & Dev. 13, 1102-1115.
(7) J. Jiang, Y. Zhang, A.R. Krainer, and R.M. Xu (1999) Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc. Natl. Acad. Sci. USA 96, 3572-3577.
(6) A. Mayeda, S.H. Munroe, R.M. Xu, and A.R. Krainer (1998) Distinct functions of the closely related tandem RNA recognition motifs of hnRNP A1. RNA 4, 1111-1123.
(5) R.M. Xu, L. Jokhan, X. Cheng, A. Mayeda, and A.R. Krainer (1997) Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure 5, 559-570.
(4) L. Jokhan, A.P. Dong, A. Mayeda, A.R. Krainer, and R.M. Xu (1997) Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Cryst. D53, 615-618.
(3) R.M. Xu, C. Koch, Y. Liu, J.R. Horton, D. Knapp, K. Nasmyth, and X. Cheng (1997) Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell cycle control of DNA synthesis. Structure 5, 349-358.
(2) R.M. Xu, G. Carmel, J. Kuret, and X. Cheng (1996) Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. Proc. Natl. Acad. Sci. USA, 93, 6308-6313.
(1) R.M. Xu, G. Carmel, R.M. Sweet, J. Kuret, and X. Cheng (1995) Crystal structure of casein kinase-1, a phosphate-directed protein kinase. EMBO J. 14, 1015-1023.

Earlier Publications in Physics

(1) R.M. Xu (1991) Why is mu/md so much smaller than mc/ms and mt/mb? Physical Review D44, 590-592.
(2) R.M. Xu (1991) "Light" Higgs particles and strongly interacting W's and Z's. Physics Letters B258, 409-414.
(3) R. Leigh, S. Paban, and R.M. Xu (1991) Electric dipole moment of electron. Nuclear Physics B352, 45-58.
(4) R.M. Xu (1990) Two-dimensional quantum (0, 2) supergravity. Physics Letters B247, 295-301.
(5) R.M. Xu (1990) A sphaleron solution in the CPN-1 model. Physics Letters B238, 333-336.
(6) R.M. Xu (1989) BRST quantization of the type II Green-Schwarz string. Intl. J. Mod. Phys. A4, 5185-5203.
(7) L. Abbott, J.Traschen, and R.M. Xu (1988). Integral constraints in general relativity. Nuclear Physics B296, 710-716.
(8) M.T. Grisaru and R.M. Xu (1988) Quantum supergravities in two dimensions. Physics Letters B205, 486-492.
(9) H. Nishino and R.M. Xu (1987) Spacetime supersymmetry breaking in heterotic string theory. Physics Letters B196, 467-472.