Na Yang, Ph.D.

Investigator

E-mail: yangna(AT)moon.ibp.ac.cn

Phone: +86-10-64889371

Fax: +86-10-64888023

Education

1996-2000　 B.S., Biophysics, Peking University, School of Life Sciences
2000-2005　 Ph.D., Structural Biology, Institute of Biophysics, Chinese Academy of Sciences

Positions Held

2005-2006　 Research assistant, Institute of Biophysics, CAS
2006-2008　 Postdoctoral Associate, Peking University
2008-2013　 Associate Professor, Institute of Biophysics, CAS
Dec.2013-Pre. Professor, Institute of Biophysics, CAS
2015 - Pre. Professor, University of CAS

Awards and Honors 　

2015 Excellent Member of the Youth Innovation Promotion Association of CAS
2014,2012 Second prize of Young Scientist Forum, the Chinese Society of Biochemistry and Molecular Biology
2011 Lu Jiaxi Young Talent Award of Chinese Academy of Sciences
2006 First prize of Chinese Postdoctor Award
2005 President prize of Chinese Academy of Sciences
2004 First prize of Director Scholarship of Institute of Biophysics
2001 Scholarship of Excellent Graduate Student in the graduate school of CAS

Professional Services

2008-2009 Secretary, Chinese Crystallographic Society
2009 Secretary General, Molecular Biophysics Section of the Chinese BiophysicalSociety
2014 Consultant, Commission on Biological Macromolecules, IUCr
2015- Member, CAS Youth Federation

Peer Reviewed Publications

[30]Fu, W.Q., Liu, N., Qiao, Q., Wang, M.Z., Min, J.R., Zhu, B.*, Xu, R.M.* and Yang, N.* (2016) Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase. J. Biol. Chem., published online March, 2016
[29]Fang, Q.L., Chen, P., Wang, M.Z., Fang, J.N., Yang, N., Li, G.H.* and Xu, R. M.* (2016) Human cytomegalovirus IE1 protein alters the higher order chromatin structure by targeting the acidic patch of the nucleosome. eLife 5, e11911.
[28] Yang, N.*, Yu, Z., Hu, M., Wang, M., Lehmann, R.*, and Xu, R.M.* (2015) Structure of Drosophila Oskar reveals a novel RNA binding protein. Proc. Natl. Acad. Sci.USA 112, 11541-11546.
[27] Cao, D., Wang, M., Qiu, X., Liu, D., Jiang, H., Yang, N.*, and Xu R.M.* (2015) Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol. Genes & Dev. 29, 1316-1325.
[26] Cao, D. and Yang, N.* (2015) Structure and catalytic mechanisms of histone deacetylases. Progress in Biochemistry and Biophysics, Vol. 42, 1-16.
[25] Wang, H., Wang, M., Yang, N.*, and Xu, R.M.* (2015) Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein & Cell 6, 693-697.
[24] Gao, G., Wang, M., Yang, N., Huang, Y., and Xu R.M.* (2015) Structure of Zeste-DNA complex reveals a new modality of DNA recognition by homeodomain-like proteins. J. Mol. Biol. 427, 3824-3833.
[23] Yu, Z ., Zhou, X., Wang, W., Deng, W., Fang, J., Hu, H., Wang, Z., Li, S., Cui, L., Shen, J., Zhai, L., Peng, S., Wong, J., Dong, S., Yuan, Z., Ou, G., Zhang, X., Xu, P., Lou, J., Yang, N., Chen, P., Xu, R.M., and Li, G. * (2015) Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell cycle-dependent deposition at centromeres. Dev. Cell, 32, 68-81.
[22] Yang, N., and Xu, R.M.* (2014) Structural Basis for Methyl DNA Readout by MBD and SRA Domains. Progress in Biochemistry and Biophysics 41, 1063-1074.
[21] Zhou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., and Xu, R.M.* (2014) Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. Mol. Cell 54, 879-886.
[20] Ren, R., Liu, H., Wang, W., Wang, M., Yang, N., Dong, Y.H., Gong, W., Lehmann, R., and Xu, R.M.*（2014）Structure and domain organization of Drosophila Tudor. Cell Res. 24, 1146-1149.
[19] Yang, D. X., Fang, Q. L., Wang, M. Z., Ren, R., Wang, H., He, M., Sun, Y. W., Yang, N.*, and Xu, R. M.* (2013) Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat. Struct. Mol. Biol., Vol. 20, 1116-1118.
[18] Yang, N.*, Wang, W., Wang, Y., Wang, M., Zhao, Q., Rao, Z., Zhu, B.* and Xu, R. M.* (2012) Distinct mode of methyl-H3K4 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci .USA, Vol. 109, 17954-17959.
[17] Yang, N. and Xu, R. M.* (2013) Structure and function of the BAH domain in chromatin biology. Crit. Rev. Biochem. Mol. Biol., Vol. 48, 211-221.
[16] Hsu, H. C., Wang, C. L., Wang, M., Yang, N., Chen, Z., Sternglanz, R.*, and Xu, R. M.* (2013) Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. Genes & Dev.,Vol. 27, 64-73.
[15] Liu, C. P., Xiong, C., Wang, M., Yu, Z., Yang, N., Chen, P., Zhang, Z., Li, G.*, and Xu, R. M.* (2012) Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat. Struct. Mol. Biol., Vol. 19, 1287-1292.
[14] Sun, L. T., Wang, M. Z., Lv, Z. Y., Yang, N., Liu, Y., Bao, S. L., Gong, W. M.* and Xu, R. M.* (2011) Structural Insights into Protein Arginine Symmetric Dimethylation by PRMT5. Proc. Natl. Acad. Sci .USA, Vol. 108, 20538-20543.
[13] Hu, H., Liu, Y., Wang, M. Z., Fang, J. N., Huang, H. D., Yang, N., Li, Y. B., Wang, J. Y., Yao, X. B., Shi, Y. Y., Li, G. H. and Xu, R. M.* (2011) Structure of a CENP-A-Histone H4 heterodimer in complex with chaperone HJURP. Genes & Dev., Vol. 25, 901-906.
[12] Yang, N., Li, D. F., Feng, L., Xiang, Y., Liu, W., Sun, H. and Wang, D. C.* (2009) Structural Basis for the Tumor Cell Apoptosis-Inducing Activity of an Antitumor Lectin from the Edible Mushroom Agrocybe aegerita. J. Mol. Biol., Vol. 387(3), 694-705.
[11] Hou, Q. M., Yang, N., Liu, X., Wang, H. F., Li, L. F. and Su, X. D.* (2011) Structural Insight into the Binding of Hypoxanthine with Purine Nucleoside Phosphorylase from Streptococcus mutants. Chinese J. Struct. Chem., Vol. 30, 43-50.
[10] Yang, N., Nan, J., N., Brostromer, E., Hatti-Kaul, R., and Su, X. D.* (2008) Crystal structure of an alkaline serine protease from Nesterenkonia sp. defines a novel family of secreted bacterial proteases. Proteins: Structure, Function and Bioinformatics, Vol. 73(4), 1072-1075.
[09] Yang, N., Hou Q. M., Nan J., and Su, X. D.* (2008) Progress in Structural and Functional Study of Ubiquitin Ligases. Progress in Biochemistry and Biophysics, Vol. 35(1), 14-20. (Chinese)
[08] Liu, W.1, Yang, N.1, Ding, J. J., Huang R. H., Hu, Z. and Wang, D. C.* (2005) Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by a novel monomeric structure. J. Biol. Chem., Vol. 280, 14865-14876. (1co-first authors)
[07] Yang, N., Tong X., Xiang, Y., Sun, H. and Wang, D. C.* (2005) Molecular character of an antitumour lectin from the edible mushroom Agrocybe aegerita. The Journal of Biochemistry, Vol. 138, 145-150.
[06] Yang, N., Xiang, Y., Zhang, Y. and Wang, D. C.* (2005) Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroom Agrocybe aegerita. Biochimica et Biophysica Acta: Proteins and Proteomics, Vol. 1751, 209-212.
[05] Yang, N., Liang, Y., Xiang, Y., Sun, H. and Wang, D. C.* (2005) Crystallization and preliminary crystallographic studies of an antitumour lectin from the edible mushroom Agrocybe aegerita. Protein and Peptide Letters, Vol. 12, 705-707.
[04] Zhu, D. Y., Zhu, Y. Q., Huang, R. H., Xiang, Y., Yang, N., Hu, Z., Li, G. P., Jin, Q. and Wang, D. C.* (2005) Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7 Å Resolution: the first structure of a new sequence family of TIM barrels. Proteins, Vol. 58, 764-768.
[03] Yin, L., Xiang, Y., Zhu, D. Y., Yang, N., Huang, Q. H., and Wang, D. C.* (2005) Crystal strucure of human SH3BGRL protein: the first structure of the human SH3BGR family repersenting a novel class of thioredoxin fold proteins. Proteins, Vol. 61, 213-216.
[02] Yin, L., Zhu, D. Y., Yang, N., Huang, Q. H., and Wang, D. C.* (2005) Expression, purification, and crystallization of a human protein SH3BGRL with atomic resolution. Acta Cryst. F61, 384-386.
[01] Zhu, Y. Q., Zhu, D. Y., Lu, H. X., Yang, N., Li, G. P. and Wang, D. C.* (2005) Purification and preliminary crystallographic studies of the Copper Homeostasis Protein (CutCm) from Shigella flexneri. Protein and Peptide Letters, Vol. 12, 823-826.

Book Chapters

[2] Yang, N. and Su, X. D. (2013) A novel alkaline serine protease isolated from Nesterenkonia abyssinica sp. nov. Handbook of Proteolytic Enzymes,3rd Edition, ISBN 9780123822192.
[1] 苏晓东, 曾宗浩, 杨娜. (2011)《现代蛋白质工程实验指南》译, 科学出版社, ISBN 978-7-03-030122-2.