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Nanozyme: Discovery and its applications in tumor diagnosis and therapy
CD146: Discovery and its applications in tumor immunotherapy
Publications
2019
lXi Hu, Fangyuan Li, Fan Xia, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan,Xiyun Yan, and Daishun Ling.Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy.J Am Chem Soc.2019 Dec 27.
lRuofei Zhang, Yunlong Zhou,Xiyun Yan*, Kelong Fan*.Advances in chiral nanozymes: a review.Mikrochim Acta.2019 Nov 15;186(12):782.
lXiangqin Meng, Iman Zare,Xiyun Yan*, Kelong Fan*.Protein-protected metal nanoclusters: An emerging ultra-small nanozyme.Wiley Interdiscip Rev Nanomed Nanobiotechnol.2019 Nov 14:e1602.
lLizeng Gao,Xiyun Yan.Nanozymes: Biomedical Applications of Enzymatic Fe3O4 Nanoparticles from In Vitro to In Vivo.Adv Exp Med Biol.2019;1174:291-312.
lXiangqin Meng, Kelong Fan*,Xiyun Yan*.Nanozymes: an emerging field bridging nanotechnology and enzymology.Sci China Life Sci.2019 Nov;62(11):1543-1546.
lShuai Zhao, Hongxia Duan, Yili Yang,Xiyun Yan*and Kelong Fan*.Fenozyme Protects the Integrity of the Blood-Brain Barrier against Experimental Cerebral Malaria.Nano Lett.2019 Dec 11;19(12):8887-8895.
lYongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng* &Xiyun Yan*.Publisher Correction: CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.Nat Commun.2019 Aug 7;10(1):3551.
lDawei Jiang, Dalong Ni, Zachary T. Rosenkrans, Peng Huang*,Xiyun Yan*and Weibo Cai*.Nanozyme: new horizons for responsive biomedical applications.Chem Soc Rev.2019 Jul 15;48(14):3683-3704.
lMinmin Liang*,Xiyun Yan*.Nanozymes: From New Concepts, Mechanisms, and Standards to Applications.Acc Chem Res.2019 Jul 5.
lYiliang Jin, Jiuyang He, Kelong Fan*,Xiyun Yan*.Ferritin variants: inspirations for rationally designing protein nanocarriers.Nanoscale.2019 Jul 14;11(26):12449-12459.
lBing Jiang, Ruofei Zhang, Jianlin Zhang, Yaxin Hou, Xuehui Chen, Meng Zhou, Xiuyun Tian, Chunyi Hao, Kelong Fan*,Xiyun Yan*.GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy.Theranostics.2019, 9(8): 2167-2182.
lBing Jiang#, Liang Yan#, Jianlin Zhang, Meng Zhou, Guizhi Shi, Xiuyun Tian, Kelong Fan*, Chunyi Hao*, andXiyun Yan*.Biomineralization synthesis of cobalt nanozyme in SP94-ferritin for targeting and visualizing hepatocellular carcinoma tissues.ACS Appl. Mater. & interfaces.2019, 11: 9747-9755.
lJiuyang He, Kelong Fan*,Xiyun Yan*.Ferritin drug carrier (FDC) for tumor targeting therapy.J Control Release.2019 Sep 5.
lBolong Xu#, Hui Wang#, Weiwei Wang#, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang,Hailong Yang, Xiangqin Meng, Qiuwen Wu, Lirong Zheng, Shenming Chen, Xinghua Shi, Kelong Fan*,Xiyun Yan*,and Huiyu Liu*.Single-Atom Nanozyme for Wound Antibacterial Applications. Angewandte Chemie International Edition.2019 Jan 29.
lHui Ding, Yanjuan Cai, Lizeng Gao, Minmin Liang, Beiping Miao, Hanwei Wu, Yang Liu, Ni Xie, Aifa Tang, Kelong Fan*,Xiyun Yan*,and Guohui Nie*.Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma.NANO LETTERS.2019, 19, 203-209
2018
lMinmin Liang#,Hui Tan#,Jun Zhou,Tao Wang,Demin Duan,Kelong Fan,Jiuyang He,Dengfeng Cheng*,Hongcheng Shi*,Hak Soo Choi*, andXiyun Yan*.Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis.ACS Nano.2018 Sep 25;12(9):9300-9308.
lZhuobin Xu, Zhiyue Qiu, Qi Liu, Yixin Huang, Dandan Li, Xinggui Shen, Kelong Fan, Juqun Xi, Yunhao Gu, Yan Tang, Jing Jiang, Jialei Xu, Jinzhi He, Xingfa Gao, Yuan Liu, Hyun Koo,Xiyun Yan, Lizeng Gao*.Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections.Nat Commun.2018 Sep 13;9(1):3713.
lYang Du#, Kelong Fan#, Hejun Zhang#, Li Li, Peixia Wang, Jiuyang He, Shigang Ding*,Xiyun Yan*,Jie Tian*.Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle.Nanomedicine: NBM.2018 Jul 26;14(7):2259-2270.
lKelong Fan andXiyun Yan.Chapter 6 - Bioengineered Ferritin Nanoprobes for Cancer Theranostics. in Handbook of Nanomaterials for Cancer Theranostics, J. Conde, Editor. 2018, Elsevier. p. 143-175.
lBing Jiang, Demin Duan, Lizeng Gao, Mengjie Zhou, Kelong Fan, Yan Tang, Juqun Xi, Yuhai Bi, Zhou Tong, George Fu Gao, Ni Xie, Aifa Tang, Guohui Nie, Minmin Liang andXiyun Yan.Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes.Nat Protoc.2018 Jul 2.
lYanbin Ma, Haofeng Zhang, Chaoliang Xiong, Zheng Liu, Qingji Xu, Jing Feng, Jun Zhang, Zhaoqing Wang,Xiyun Yan.CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.Cancer Lett.2018 Aug 28;430:201-214.
lLingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng&Xiaofeng Zeng&Xiyun Yan.CD146: a potential therapeutic target for systemic sclerosis.Protein Cell. 2018 Apr 18.
lKelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang,Bing Jiang,Xiyun Yan&Lizeng Gao.In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy.Nat Commun. 2018 Apr 12;9(1):1440.
lKelong Fan, Bing Jiang, Zhe Guan, Jiuyang He, Dongling Yang, Ni Xie, GuohuiNie, Can Xie,Xiyun Yan.Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension.Anal Chem.2018 Apr 10.
lKelong Fan, Xiaohua Jia, Meng Zhou, Kun Wang, Joao Conde, Jiuyang He, Jie Tian, Xiyun Yan.Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma.ACS Nano. 2018 Apr 4.
2017
lChen J, Luo Y, Huang H, Wu S, Feng J, Zhang J,Yan X.CD146 is essential for PDGFRβ-induced pericyte recruitment.Protein Cell. 2017 Oct 16.
lKelong Fan, Meng Zhou,Xiyun Yan.Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1.Protein Cell. 2017 Oct 9.
lLizeng Gao, Kelong Fan,Xiyun Yan.Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications.Theranostics.2017; 7(13):3207-3227.
lJianan Chen, Yongting Luo, Hui Hui, TanxiCai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang, andXiyun Yan.CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.Proc Natl AcadSci U S A.2017 Aug 21.
lHuiwen Yan,Chunxia Zhang,Zhaoqing Wang,Tao Tu,Hongxia Duan,Yongting Luo,Jing Feng,Feng Liu, andXiyun Yan.CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis.Scientific Reports.2017 Aug 7;7(1):7442.
lQian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, AnmingMeng,andXiyun Yan.The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis.Nature Communications.2017 Jun 7;8:15279.
lYongting Luo, HongxiaDuan, Yining Qian, Liqun Feng, Zhenzhen Wu, Fei Wang, Jing Feng, Dongling Yang, Zhihai Qin,Xiyun Yan.Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis.Cell Research.2017 Mar;27(3):352-372.
2016
lFan K, Wang H, Xi J, Liu Q, Meng X, Duan D, Gao L,Yan X.Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site.Chem Commun (Camb).2016 Dec 22;53(2):424-427.
lDan Liu, Lei Du, Dong Chen, Zhongde Ye, Hongxia Duan, Tao Tu, Jing Feng, Yili Yang, Quan Chen,Xiyun Yan*.Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling.Oncotarget.2016 Jun 9.
lLizeng Gao ,Xiyun Yan*.Nanozymes: an emerging field bridging nanotechnology and biology.Science China-Life Science. 2016 Apr;59(4):400-2.
lYanzhao Zhao, Minmin Liang, Xiao Li, Kelong Fan, Jie Xiao, Yanli Li, Hongcheng Shi, Fei Wang,Hak Soo Choi,* Dengfeng Cheng,* andXiyun Yan*.Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging.ACS Nano.2016; 10 (4), 4184–4191
2015
lDemin Duan, Kelong Fan, Dexi Zhang, ShuguangTan, Mifang Liang, Yang Liu, Jianlin Zhang, PanheZhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger,George Fu Gao,Xiyun Yan*.Nanozyme-strip for rapid local diagnosis of Ebola.Biosensors and Bioelectronic.2015;74(5),134-141.
lTao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y. Wu*,Xiyun Yan*..CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development.Cell Research.2015;25(3), 275-87.
2014
lYimin Qian,Yongting Luo, Hongxia Duan, Liqun Feng,Qi Bi, Yongjun Wang,Xiyun Yan*.Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability.Cns Neuroscience & Therapeutics. 2014; 20,438-45.
lMinmin Liang, Kelong Fan, Meng Zhou, Demin Duan, Jiyan Zheng, Dongling Yang, Jing FengandXiyun Yan*.H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection.Proc Natl Acad Sci U S A.2014;111(41) ,14900-5.
lQiqun Zeng, Peng Zhang, Zhenzhen Wu, Peng Xue, Di Lu, Zhongde Ye, Xinlei Zhang, Zechi Huang, Jing Feng, Lina Song, Dongling Yang, Taijiao Jiang,Xiyun Yan*.Quantitative proteomics reveals ER-involvement in CD146-induced epithelial-mesenchymal transition in breast cancer cells.Journal of Proteomics, 2014; 103,153-69.
lShu Xing, Yongting Luo, Zhihua Liu, Pengcheng Bu, Hongxia Duan, Dan Liu, Ping Wang, Jing Yang, Lina Song, Jing Feng, Dongling Yang, Zhihai Qin,Xiyun Yan*.Targeting endothelial CD146 attenuates colitis and prevents colitis associated carcinogenesis.The American Journal of Pathology.2014;184(5),1604-16.
lQiqun Zeng, Zhenzhen Wu, Hongxia Duan, Xuan Jiang, Tao Tu, Di Lu, Yongting Luo, Ping Wang, Lina Song, Jing Feng, Dongling Yang,Xiyun Yan*.Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice.Protein Cell.2014; 5(6),445–456.
lQian Gao, Xiongfei Chen, Hongxia Duan, Zhaoqing Wang, Jing Feng, Dongling Yang, Lina Song, Ningxin Zhou, andXiyun Yan*.FXYD6: a novel therapeutic target toward hepatocellular carcinoma.Protein Cell.2014;5(7),532-43.
2013
lZhongde Ye, Chunxia Zhang, Tao Tu, Min Sun, Dan Liu, Di Lu, Jing Feng, Dongling Yang,Feng Liu*&Xiyun Yan*.Wnt5a uses CD146 as a receptor to regulatecell motility and convergent extension.Nature Communications. 2013;4,2803.
lPing Wang, Yongting Luo, Hongxia Duan, Shu Xing, Jianlin Zhang, Di Lu, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*.MicroRNA 329 Suppresses Angiogenesis by Targeting CD146.Molecular and Cellular Biology. 2013;33(18),3689-99.
lTao Tu, Qian Gao, Yongting Luo, Jianan Chen, Di Lu, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*.CD146 Deletion in the Nervous System Impairs Appetite,Locomotor Activity and Spatial Learning in Mice.PLoS ONE.2013;8(9),e74124.
lFei Wang, Xichong Yan, Lina Song, Ping Wang, Di Lu, Jing Feng, Dongling Yang,Xiyun Yan*.A novel 'pipeline' system for downstream preparation of therapeutic monoclonal antibodies.Biotechnology Letters.2013; 35,1411-8.
lHongxia Duan, Shu Xing, Yongting Luo, Liqun Feng, Irene Gramaglia, Ying Zhang, Di Lu, Qiqun Zeng, Kelong Fan, Jing Feng, Dongling Yang, Zhihai Qin, Pierre-Olivier Couraud, Ignacio A. Romero, Babette Weksler,Xiyun Yan*.Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS.Scientific Reports.2013; 3,1687.
lKelong Fan, Lizeng Gao,Xiyun Yan*.Human ferritin for tumor detection and therapy.Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2013; 5(4), 287-98.
lHongxia Duan, Yongting Luo, Hongjun Hao,Liqun Feng, Ying Zhang, Di Lu, Shu Xing, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*.Soluble CD146 in cerebrospinal fluid ofactive multiple sclerosis.Neuroscience. 2013; 235,16-26.
lHaofeng Zhang, Jun Zhang, Zhaoqing Wang, Di Lu, Jing Feng, Dongling Yang, Xiuqin Chen,Xiyun Yan*.CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer.Oncology Letters. 2013 Apr;5(4),1189-1194.
lMinmin Liang, Kelong Fan, Yong Pan, Hui Jiang, Fei Wang, Dongling Yang, Di Lu, Jing Feng, Jianjun Zhao, LiuYang,Xiyun Yan*.Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent.Analytical Chemistry. 2013; 85(1),308-12.
lZhaoqing Wang,Xiyun Yan*.CD146, a multi-functional molecule beyond adhesion.Cancer Letters. 2013; 330(2),150-62.
lYunhe An,Wei Han, Xiuqin Chen, Xiaohang Zhao, Di Lu, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*.A novel anti-sTn monoclonal antibody 3P9 inhibits human xenografted colorectal carcinomas.Journal of Immunotherapy. 2013;36(1),20-8.
lDemin Duan, Lixing Hui, Lishi Li,Xiyun Yan*, Jiong Li*.Establishment and Optimization of a Label free microRNA Microarray Analytical Method.Progress in Biochemistry and Biophysics. 2013;40(5),479-89.
2012
lKelong Fan, Changqian Cao, Yongxin Pan, Di Lu, Dongling Yang, Jing Feng,Lina Song, Minmin Liang &Xiyun Yan*.Magnetoferritin nanoparticles for targeting and visualizing tumor tissues.Nature Nanotechnology. 2012; 7(7),459-64.
(Highlighted by commentary articles in GEN 2012,6)
lTianxia Jiang, Jie Zhuang, Hongxia Duan, Yongting Luo, Qiqun Zeng, Kelong Fan, Huiwen Yan, Di Lu, Zhongde Ye, Junfeng Hao, Jing Feng, Dongling Yang,Xiyun Yan*.CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis.Blood. 2012; 120(11),2330-9.
(Highlighted by commentary articles in Blood 2012,9,(120)2164-2165)
lQiqun Zeng, Weidong Li, Di Lu, Zhenzhen Wu, Hongxia Duan, Yongting Luo, Jing Feng, Dongling Yang, Li Fu, andXiyun Yan*.CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer.Proceedings of the National Academy of Sciences of the United States of America. 2012;109(4),1127-32.
lYongting Luo, Chaogu Zheng, Jinbin Zhang, Di Lu, Jie Zhuang, Shu Xing, Jing Feng, Dongling Yang,Xiyun Yan*.Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration.Oncogene.2012;31(3),306-21.
lJie Zhuang,Kelong Fan,Lizeng Gao,Di Lu,Jing Feng,Dongling Yang,Ning Gu, Yu Zhang, Minmin Liang andXiyun Yan*.Ex Vivo Detection of iron oxide magnetic nanoparticles in mice using their intrinsic peroxidase-mimicking activity.Molecular Pharmaceutics. 2012;9(7),1983-9.
lYunhe An, Haofeng Zhang, Min Sun, Jun Zhang, Xiuqin Chen, Dong Chen, Di Lu, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*.sTn is a novel biomarker for type endometrial carcinoma.Progress in Biochemistry and Biophysics. 2012; 39(6),548-55.
2011
lChaogu Zheng, Jing Feng, Di Lu, Ping Wang, Shu Xing, Jean-Luc Coll, Dongling Yang,Xiyun Yan*.A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity.PLoS ONE. 2011;6(6),e21146.
lDemin Duan, Kexiao Zheng, Ye Shen, Rong Cao, Li Jiang, Zhuoxuan Lu,Xiyun Yanand Jiong Li*.Label-free high-throughput microRNA expressionprofiling from total RNA.Nucleic Acids Research.2011; 39(22), e154.
lWeidong Li, Dongling Yang, Shuling Wang, Xiaojing Guo, Ronggang Lang, Yu Fan, Feng Gu,Xinmin Zhang, Yun Niu,Xiyun Yan*, Li Fu*.Increased expression of CD146 and microvessel density (MVD) in invasivemicropapillary carcinoma of the breast: Comparative study with invasive ductalcarcinoma-not otherwise specified.PathologyResearch and Practice.2011; 207(12),739-46.
lYu Niu, Jie Zhuang, Li Liu,Xiyun Yan, Gang Jin*.Two kinds of anti-ricin antibody and ricin interaction evaluated by biosensor basedon imaging ellipsometry.Thin Solid Films.2011; 519(9),2768-2771.
2010
lXinglu Huang, Jie Zhuang, Xu Teng,Linlin Li, Dong Chen,Xiyun Yan, Fangqiong Tang*.The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species.Biomaterial, 2010; 31(24), 6142-6153.
lBin Mu, Xinglu Huang, Pengcheng Bu, Jie Zhuang, Zhixue Cheng, Jing Feng,Dongling Yang,Changsheng Dong, Jianbing Zhang,Xiyun Yan*.Influenza virusdetectionwithpentabody-activatednanoparticles.Journal ofVirologicalMethods. 2010;169,282-289.
lJie Zhuang, Tianxia Jiang, Di Lu, Yongting Luo, Chaogu Zheng, Jing Feng, Dongling Yang, Chang Chen,Xiyun Yan*.NADPH oxidase4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction.Free Radical Biology & Medicine. 2010; 49,227-236.
lJieZhuang, Tao Cheng, Lizeng Gao, Yongting Luo, Quan Ren, Di Lu,Fangqiong Tang, Xiangling Ren, Dongling Yang, Jing Feng, Jingdong Zhu,Xiyun Yan*.Silica coating magnetic nanoparticle-based silver enhancement immunoassay for rapid electrical detection of ricin toxin.Toxicon. 2010; 55(1), 145-52.
2009
lBairu Zhang, Ling Li, Ying Zhang, Xiaofeng Zeng, Liqun Feng, Jing Feng, Dongling Yang, Chaogu Zheng,Xiyun Yan*.Elevated levels of soluble and neutrophil CD146 in active systemic vasculitis.Labmedicine. 2009; 40 (6),351-356.
lXinglu Huang, Jie Zhuang, DongChen, Huiyu Liu, Fangqiong Tang*,Xiyun Yan, Xianwei Meng, Lin Zhang, Jun Ren.General strategy for designing functionalized magnetic microspheres for different bioapplications.Langmuir.2009;25(19),11657-63.
lChaogu Zheng, Yijun Qiu, Qiqun Zeng, Ying Zhang, Di Lu, Dongling Yang,Jing Feng,Xiyun Yan*.Endothelial CD146 is required for in vitro tumor-induced angiogenesis:The role of a disulfide bond in signaling and dimerization.The International Journal of Biochemistry and Cell Biology. 2009; 41(11), 2163-72.
lCai Qi, Yi Lin, Jing Feng, Zhanhui Wang, Chuanfeng Zhu, Yonghong Meng,Xiyun Yan, Lijun Wan, Gang Jin*.Phage M13KO7 detection with biosensor based on imaging ellipsometryand AFM microscopic confirmation.Virus Research. 2009; 140(1-2),79-84.
2008
lChangcheng Yin, Lili Ren, Linlin Zhu, Xiangbin Wang, Zhong Zhang,Hualiang Huang,Xiyun Yan*.Construction of a fully synthetic human scFv antibody librarywith CDR3 regions randomized by a split–mix–split method and its application.The Journal of Biochemistry. 2008;144,591-8 .
lShufen Wang, Yi Shen, Xiaohua Yuan, Kai Chen, Xiangyu Guo, Yongchang Chen, Yuyu Niu, Jian Li, Renhe Xu,Xiyun Yan*, Qi Zhou*, Weizhi Ji*.Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells.The Journal of Biological Chemistry. 2008;283 (51),35929-40.
lYing Zhang, Chaogu Zheng, Jinbin Zhang, Dongling Yang, Jing Feng, Di Lu,Xiyun Yan*.Generation and Characterization of a panel of monoclonal antibodies against distinctepitopes of human CD146.Hybridoma. 2008;27(5),345-52.
lJie Zhuang, Jinbin Zhang, Lizeng Gao, Yu Zhang, Ning Gu, Jing Feng, Dongling Yang,Xiyun Yan*.A novel application of iron oxide nanoparticles for detection of hydrogenperoxide in acid rain.Materials Letters. 2008;62,3972-4.
lJinbin Zhang, Jie Zhuang, Lizeng Gao, Yu Zhang, Ning Gu, Jing Feng, Dongling Yang,Xiyun Yan*.Decomposing phenol by the hidden talent of ferromagnetic nanoparticles.Chemosphere.2008;73(9),1524-8.
lShuyan Zhang, Chaogu Zheng,Xiyun Yan, Weixi Tian*.Low concentration of condensed tannins from catechu significantly inhibitsfatty acid synthase and growth of MCF-7 cells.Biochemical and Biophysical Research Communications. 2008;371(4),654-8.
lChaogu Zheng,Xiyun Yan*.Progress in epigenetic regulation of V(D)J recombination.Progress in Biochemistry and Biophysics. 2008; 35(2),133-42.
lQinLiu, Bairu Zhang, Xingang Zhao, Ying Zhang,Yixun Liu,Xiyun Yan*.Blockade of adhesionmolecule CD146 causes pregnancy failure in mice.Journal of Cellular Physiology. 2008; 215(3),621-6.
lLeyu Wang, Peng Li, Jie Zhuang, Feng Bai, Jing Feng,Xiyun Yan, Yadong Li*.Carboxylic acid enriched nanospheres of semiconductor nanorods for cell imaging.Angewandte Chemie International Edition.2008; 47(6),1054-7.
2007
lLizeng Gao, Jie Zhuang, Leng Nie, Jinbin Zhang, Yu Zhang, Ning Gu, Taihong Wang, Jing Feng, Dongling Yang, Sarah Perrett,Xiyun Yan*.Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.Nature Nanotechnology. 2007; 2 (9) ,577-83.
(Highlighted by commentary articles in Nature Nanotechnology 2007,(2),535-36; Science News 2007,11(172),174; Nature China 2007,8; Chem Soc Rev 2012,41,2122-34)
lYun Lin, Xiaoping Wu, Yi Shen, Pengcheng Bu, Dongling Yang,Xiyun Yan*.A novel antibody AA98 VH/L directed against CD146 efficiently inhibits angiogenesis.Anticancer Research.2007; 27 (6B),4219-24.
lPengcheng Bu, Jie Zhuang, Jing Feng, Dongling Yang, Xun Shen,Xiyun Yan*.Visualization of CD146 dimerization and its regulation in living cells.Biochimica et Biophysica Acta (BBA) -Molecular Cell Research.2007; 1773 (4) ,513-20.
lLeng Nie, Lizeng Gao, Xiyun Yan, Taihong Wang*.Functionalized tetrapod-like ZnO nanostructrures for DNA gene delivery.Solid State Phenomena. 2007; 121,747-50.
2006
lXiyun Yan*.Angiogenesis-A novel therapeutic target.Journal of Medical Molecular Biology. 2006; 3(5), 323-30.
lCai Qi, Jinzhu Duan, Zhanhui Wang, Yanyan Chen, Panhe Zhang, Lin Zhan,Xiyun Yan,Wuchun Cao, Gang Jin*.Investigation of interaction between two neutralizing monoclonal antibodies and SARS virus using biosensor based on imaging ellipsometry.Biomed Microdevices. 2006; 8(3), 247-53.
lLeng Nie, Lizeng Gao, Ping Feng, Jingyuan Zhang, Xingqiu Fu, Yonggang Liu,Xiyun Yan, Taihong Wang*.Three-Dimensional Functionalized Tetrapodlike ZnO Nanostructures for Plasmid DNA Delivery.Small. 2006; 2(5), 621-5.
lPengcheng Bu, Lizeng Gao, Jie Zhuang, Jing Feng, Dongling Yang,Xiyun Yan*.Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kB activation.Molecular Cancer Therapeutics. 2006; 5(11), 2872-8.
lLizeng Gao, Leng Nie, Taihong Wang, Yujun Qin, Zhixin Guo, Dongling Yang,Xiyun Yan*.Carbon nanotubes delivery of the GFP-geneinto mammalian cells.ChemBioChem. 2006; 7 (2) , 239- 42.
lJinzhu Duan, Xin Ji, Jing Feng, Wei Han, Panhe Zhang, Wuchun Cao, Xueming Guo, Cai Qi, Dongling Yang, Gang Jin, Guangxia Gao,Xiyun Yan*.A human neutralizing antibody against a conformational epitope shared by oligomeric SARS S1 protein.Antiviral therapy. 2006; 11(1), 117-23.
lYanyong Kang, Fengcai Wang, Jing Feng, Dongling Yang, Xu Yang,Xiyun Yan*.Knockdown of CD146 reduces the migration and proliferation of human endothelial cells.Cell Research. 2006; 16(3), 313-8.
lYun Lin, Jing Feng, Dongling Yang, Yi Shen,Xiyun Yan*.Suppression of Human Hepatoma Growth In Vivo by a Monoclonal Antibody against a Mr 45,000 Protein.Cancer Investigation.2006; 24(8), 734-9.
lJing Feng, Yi Shen, DongLing Yang,Xiyun Yan*.A novel monoclonal antibody with a mono-specificity for a 46 kD-cytokeratin.Progress in Biochemistry and Biophysics. 2006;33 (1) , 24-30.
2005
lJinzhu Duan,Xiyun Yan*,Xueming Guo, Wuchun Cao, Wei Han, Cai Qi, Jing Feng, Dongling Yang,Guangxia Gao, Gang Jin.A human SARS-CoV neutralizing antibody against epitope on S2 protein.Biochemical Biophysical Research Communication. 2005; 333(1), 186-93.
2004
lYun Lin,Xiyun Yan*, Wuchun Cao, Chaoying Wang, Jing Feng, Jinzhu Duan, Sishen Xie.Probing the Structure of the SARS Coronavirus Using Scanning Electron Microscopy.Antiviral Therapy. 2004; 9(2), 287-289.
lQin Liu,Xiyun Yan*, Yang Li, Ying Zhang, Xingang Zhao, Yi Shen.Pre-eclampsia is associated with the failure of melanoma cell adhesion molecule (MCAM/CD146) expression by intermediate trophoblast.Lab Investigation. 2004; 84, 221-228.
lAndrea Bernini, Ottavia Spiga, Arianna Ciutti, Stefano Chiellini, Luisa Bracci,Xiyun Yan, Bojian Zheng, Jiandong Huang, Mingliang He, Huaidong Song, Pei Hao, Guoping Zhao, Neri Niccolai*.Prediction of quaternary assembly of SARS coronavirus peplomer.Biomolecular Structure Research Center & D BBCR. 2004; 325, 1210-4.
2003
lXiyun Yan*, Yun Lin, Dongling Yang, Yi Shen, Mei Yuan, Zhiqiang Zhang, Peiyu Li, Hongtian Xia, Li Li, Dandan Luo, Qin Liu,Karlheinz Mann, Bernhard L Bader.A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth.Blood. 2003; 102 (1), 184-91.
(Highlighted by commentary articles in Faculty of 1000 Biology 2007(12).)
XlXiufang Xu, Yi Shen, Jing Wang, Feili Gong,Xiyun Yan*.Immuno-detection of exfoliated cells in sputum with a monoclonal antibody.The Chinese-German Journal of Clinical Oncology. 2003; 2(2), 110-3.
Prior to 2003
lFang Fang, Lin Wang, Xiaojie Qi,Xiyun Yan,Lan Ding*, Daqing Zhao, Jiazuan Ni*.Human catalytic antibodies with glutathione peroxidase activity.Journal of Inorganic Biochemistry. 2001; 85 (4), 301-7.
lLi Guo,Jinhua Wang,Xiyun Yan,Runsheng Chen, Shijun Qian*, Guangzhen Meng.Characterization of L-asparaginase fused with a protective ScFv and stabilization mechanism.Biochemical and Biophysical Research Communications. 2000; 276(1), 197- 203.
lLi Guo,Jinhua Wang,Shijun Qian,Xiyun Yan,Runsheng Chen,Guangzhen Meng*.Construction and Structural Modeling of a Single-Chain Fv-Asparaginase Fusion Protein Resistant to Proteolysis.Biotechnology and bioengineering. 2000; 70(4), 456-63.
lXiyun Yan*, Jian Tang,Xiaoping Wu, Fengcai Wang, Jiansheng Li, Dongling Yang.Human single chain antibody to vascular endothelial growth factor: gene cloning, high-level expression, affinity maturation and bioactivity.SCIENCE IN CHINA(Series C).2000; 43(3), 232-238.
lLi Guo,Xiyun Yan, Shijun Qian*, Guangzhen Meng.Selecting and expressing protective single-chain fv fragment to stabilize L-asparaginase against inactivation by trypsin.Bio-technology and Applied Biochemistry. 2000; (31), 21-27.
lPeiyu Li, Mei Yuan,Xiyun Yan*.Anti-tumor effect of an Anti-endothelial cell monoclonal antibody on solid tumor xenograft in nude mice.Chinese Journal of Cancer Research. 1999; 11(2), 92.
lXiyun Yan*, Xiaoping Wu,Li Li.A human single-chain Fv target to an antigen on stimulated human umbilical vein endothelial cells.Proceedings of the American Association for Cancer Research.1999; 40, 558.
lXiyun Yan*, Jian Tang, Xiaoping Wu.A human single-chain Fv to vascular endothelial growth factor.Proceedings of the American Association for Cancer Research. 1999; 40, 70.
lJian Tang,Xiyun Yan*, Yuanyi Liu, Huasong Tian, Po Tian.Production and characterization of a human single-chain Fv to collagenase IV.Science in China (Series C).1998; 41(4), 387-92.
lYanxing Yu, Mei Yuan, Li Li,Xiyun Yan*.Expression and characterization of a recombinant IL2-single chain antibody fusion protein in E.Coli.High Technology letters. 1997; 3(1), 101-5.
lXiyun Yan*, Po Tian.Human antibodies from a single-chain Fv fusion phage library.Chinese Science Bulletin.1997; 42(15), 1300-3.
lMei Yuan, Li Li,Xiyun Yan*.Gene cloning, expression and immunoreactivity of a single chain Fv-fragment antibody PS-9.High Technology Letters. 1996; 2, 99-102.
lXiyun Yan*, Stephen V.Evans, Marcin J. Kaminke, Stephen D.Gillies, Ralph A.Reisfeld, Alan N. Houghton, Paul B. Chapman.Characterization of an Ig VH idiotope that results in specific homophilic binding and increased avidity for antigen.Journal of Immunology. 1996; 157(4), 1582-8.
lXiyun Yan*, KuhnS,Traub P.A complex of intermediate filament protein-DNA: A target for autoantibodies in systemic lupus erythematosus.Journal of Chinese Medical Sciences. 1995; 10(2), 90-92.
lXiyun Yan*, Li Li, Mei Yuan, Po Tian.Cloning, expression and characterization of a single-chain antibody PS-9 targeted to pancreatic cancer.Science in China, Series B. 1995; 38(10), 1230-6.
lXiyun Yan*.A new method for purification of anti-DNA antibodies.Journal of Chinese Medical Sciences. 1994; 9(1), 208-10.
