Social attraction inDrosophilais regulated by the mushroom body and serotonergic system
Yuanjie Sun, Rong Qiu, Xiaonan Li, Yaxin Cheng, Shan Gao, Fanchen Kong, Li Liu & Yan Zhu
Abstract
Sociality is among the most important motivators of human behaviour. However, the neural mechanisms determining levels of sociality are largely unknown, primarily due to a lack of suitable animal models. Here, we report the presence of a surprising degree of general sociality inDrosophila. A newly-developed paradigm to study social approach behaviour in flies reveal that social cues perceive through both vision and olfaction converged in a central brain region, the γ lobe of the mushroom body, which exhibite activation in response to social experience. The activity of these γ neurons control the motivational drive for social interaction. At the molecular level, the serotonergic system is critical for social affinity. These results demonstrate thatDrosophilaare highly sociable, providing a suitable model system for elucidating the mechanisms underlying the motivation for sociality.
附件下载：
Social attraction inDrosophilais regulated by the mushroom body and serotonergic system,Nat Commun, 22 Oct 2020
Nature Communications, 22 October, 2020, DOI：https://doi.org/10.1038/s41467-020-19102-3
Social attraction inDrosophilais regulated by the mushroom body and serotonergic system
Yuanjie Sun, Rong Qiu, Xiaonan Li, Yaxin Cheng, Shan Gao, Fanchen Kong, Li Liu & Yan Zhu
Abstract
Sociality is among the most important motivators of human behaviour. However, the neural mechanisms determining levels of sociality are largely unknown, primarily due to a lack of suitable animal models. Here, we report the presence of a surprising degree of general sociality inDrosophila. A newly-developed paradigm to study social approach behaviour in flies reveal that social cues perceive through both vision and olfaction converged in a central brain region, the γ lobe of the mushroom body, which exhibite activation in response to social experience. The activity of these γ neurons control the motivational drive for social interaction. At the molecular level, the serotonergic system is critical for social affinity. These results demonstrate thatDrosophilaare highly sociable, providing a suitable model system for elucidating the mechanisms underlying the motivation for sociality.
文章链接：https://www.nature.com/articles/s41467-020-19102-3
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