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H2O2Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy...,Adv Funct Mater, 4 Jan 2022

发布时间:2022年01月04日

Advanced Functional Materials, 4 January, 2022. DOI:https://doi.org/10.1002/adfm.202110268

H2O2Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming “Cold” Tumors

Daoming Zhu, Hao Chen, Chunyu Huang, Guoxin Li, Xing Wang, Wei Jiang, Kelong Fan

Abstract

Single-atom nanozyme (SAzyme) with peroxidase-like activity can alter cellular redox balance and shows promising potential for tumor therapy. However, the “cold” immune microenvironment and limited amount of hydrogen peroxide (H2O2) in solid tumors severely restrict its efficacy. Herein, a light-controlled oxidative stress amplifier system is designed by co-encapsulating Pd-C SAzymes and camptothecin in agarose hydrogel, which exhibits enhanced synergistic antitumor activity by self-producing H2O2and transforming “cold” tumors. In this nanozyme hydrogel system, the Pd-C SAzyme converts near-infrared laser into heat, resulting in agarose degradation and consequent camptothecin release. The camptothecin increases H2O2level in tumors by activating nicotinamide adenine dinucleotide phosphate oxidase, improving the catalytic performance of SAzymes with peroxidase-like activity. Moreover, the combination of photothermal therapy, chemotherapy, and nanozyme-based catalytic therapy further facilitates tumor immunogenic death and enhanced antitumor immunity. The results reveal the synergistic antitumor potential of the novel SAzyme/chemotherapeutics-based hydrogel system.

文章链接:https://onlinelibrary.wiley.com/doi/10.1002/adfm.202110268

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